YGL068W / MNP1

Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL068W / MNP1

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:3.13|P-value:9.37E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.67|P-value:1.28E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.29|P-value:9.61E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:5.08|P-value:2.03E-7 ID:SGTC_141|Compound:0443-0274|FD-Score:4.34|P-value:7.82E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:4.38|P-value:6.37E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:3.99|P-value:3.54E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.52|P-value:2.34E-4 ID:SGTC_459|Compound:nigericin|FD-Score:-3.36|P-value:3.34E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.37|P-value:4.02E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.60|P-value:1.74E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.78|P-value:8.30E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.95|P-value:3.30E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.09|P-value:8.68E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:6.17|P-value:3.64E-10 ID:SGTC_853|Compound:0419-0306|FD-Score:3.18|P-value:7.90E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.46|P-value:2.93E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.36|P-value:4.25E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.25|P-value:5.07E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.86|P-value:6.02E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.41|P-value:3.55E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.59|P-value:1.80E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.31|P-value:4.00E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.16|P-value:8.33E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.73|P-value:1.21E-6 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.22|P-value:6.89E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.30|P-value:4.21E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.77|P-value:8.72E-5 ID:SGTC_1763|Compound:st044482|FD-Score:3.43|P-value:3.30E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.01|P-value:2.88E-7 ID:SGTC_1825|Compound:st052143|FD-Score:-3.75|P-value:7.57E-5 ID:SGTC_2013|Compound:4024628|FD-Score:4.77|P-value:1.00E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.31|P-value:4.02E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.86|P-value:6.21E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.96|P-value:4.00E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.71|P-value:1.33E-6 ID:SGTC_2468|Compound:5987765|FD-Score:3.42|P-value:3.36E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.55|P-value:2.08E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.88|P-value:5.58E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.68|P-value:1.01E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.76|P-value:9.04E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.25|P-value:5.12E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.37|P-value:4.11E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.19|P-value:7.57E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.55|P-value:1.68E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.90|P-value:4.13E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.24|P-value:5.25E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.71|P-value:1.14E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.25|P-value:6.10E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.48|P-value:2.69E-4 ID:SGTC_3243|Compound:9134147|FD-Score:4.33|P-value:7.98E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.13|P-value:9.37E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.67|P-value:1.28E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.29|P-value:9.61E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:5.08|P-value:2.03E-7 ID:SGTC_141|Compound:0443-0274|FD-Score:4.34|P-value:7.82E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:4.38|P-value:6.37E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:3.99|P-value:3.54E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.52|P-value:2.34E-4 ID:SGTC_459|Compound:nigericin|FD-Score:-3.36|P-value:3.34E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.37|P-value:4.02E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.60|P-value:1.74E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.78|P-value:8.30E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.95|P-value:3.30E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.09|P-value:8.68E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:6.17|P-value:3.64E-10 ID:SGTC_853|Compound:0419-0306|FD-Score:3.18|P-value:7.90E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.46|P-value:2.93E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.36|P-value:4.25E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.25|P-value:5.07E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.86|P-value:6.02E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.41|P-value:3.55E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.59|P-value:1.80E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.31|P-value:4.00E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.16|P-value:8.33E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.73|P-value:1.21E-6 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.22|P-value:6.89E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.30|P-value:4.21E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.77|P-value:8.72E-5 ID:SGTC_1763|Compound:st044482|FD-Score:3.43|P-value:3.30E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.01|P-value:2.88E-7 ID:SGTC_1825|Compound:st052143|FD-Score:-3.75|P-value:7.57E-5 ID:SGTC_2013|Compound:4024628|FD-Score:4.77|P-value:1.00E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.31|P-value:4.02E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.86|P-value:6.21E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.96|P-value:4.00E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.71|P-value:1.33E-6 ID:SGTC_2468|Compound:5987765|FD-Score:3.42|P-value:3.36E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.55|P-value:2.08E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.88|P-value:5.58E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.68|P-value:1.01E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.76|P-value:9.04E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.25|P-value:5.12E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.37|P-value:4.11E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.19|P-value:7.57E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.55|P-value:1.68E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.90|P-value:4.13E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.24|P-value:5.25E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.71|P-value:1.14E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.25|P-value:6.10E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.48|P-value:2.69E-4 ID:SGTC_3243|Compound:9134147|FD-Score:4.33|P-value:7.98E-6

Top fitness defect scores for YGL068W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_852 0418-0143 6.17 439.0 µM 3.64E-10 calcium & mitochondrial duress 3 3.36E-10 0.53
2 SGTC_124 0136-0217 5.08 7.1 µM 2.03E-7 mitochondrial stress 13 1.87E-7 0.02
3 SGTC_1785 bathophenanthroline 5.01 24.0 µM 2.88E-7 heme requiring 12 2.65E-7 0.05
4 SGTC_2013 4024628 4.77 200.0 µM 1.00E-6 7 9.24E-7 0.19
5 SGTC_1539 benzyladenosine 4.73 56.0 µM 1.21E-6 5 1.11E-6 0.69
6 SGTC_2418 pentamidine 4.71 31.7 µM 1.33E-6 mitochondrial processes 11 1.23E-6 0.03
7 SGTC_173 1273-0061 4.38 2.7 µM 6.37E-6 mitochondrial stress 20 5.88E-6 0.01
8 SGTC_141 0443-0274 4.34 32.3 µM 7.82E-6 mitochondrial response to ROS 3 7.22E-6 0.23
9 SGTC_3243 9134147 4.33 49.5 µM 7.98E-6 2 7.37E-6 0.18
10 SGTC_119 0121-0043 4.29 24.8 µM 9.61E-6 mitochondrial stress 15 8.87E-6 0.05
11 SGTC_348 k064-0012 3.99 10.7 µM 3.54E-5 60S ribosome export 4 3.28E-5 0.00
12 SGTC_2417 cerulenin 3.96 830.0 nM 4.00E-5 10 3.70E-5 5.27E-4
13 SGTC_2564 betulinic acid 3.88 100.0 µM 5.58E-5 8 5.17E-5 0.08
14 SGTC_1159 4092-0538 3.86 61.2 µM 6.02E-5 4 5.57E-5 0.02
15 SGTC_2408 sulbentine 3.86 18.4 µM 6.21E-5 36 5.75E-5 0.12
16 SGTC_674 0498-0004 3.78 451.0 µM 8.30E-5 heme requiring 23 7.69E-5 0.01
17 SGTC_1708 st033234 3.77 31.8 µM 8.72E-5 4 8.08E-5 0.08
18 SGTC_2640 pentamidine 3.76 10.4 µM 9.04E-5 mitochondrial processes 20 8.37E-5 0.03
19 SGTC_3062 9077494 3.71 49.5 µM 1.14E-4 mitochondrial response to ROS 10 1.06E-4 0.09
20 SGTC_116 0155-0182 3.67 31.8 µM 1.28E-4 mitochondrial response to ROS 5 1.19E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 2.56E-19 YFL036W RPO41 hom Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.149 4.43E-18 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.144 5.74E-17 YDL217C TIM22 het Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
0.140 3.38E-16 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.129 7.55E-14 YOR232W MGE1 het Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE
0.127 1.45E-13 YLR355C ILV5 het Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
0.126 3.00E-13 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.123 8.80E-13 YPL170W DAP1 hom Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
0.121 1.72E-12 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.120 3.68E-12 YFL016C MDJ1 hom Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
0.117 1.20E-11 YNR037C RSM19 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
0.116 1.40E-11 YNL006W LST8 het Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat
0.113 4.52E-11 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.113 6.15E-11 YBR179C FZO1 hom Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.112 7.48E-11 YKR085C MRPL20 hom Mitochondrial ribosomal protein of the large subunit