YGL077C / HNM1

Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL077C / HNM1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:5.92|P-value:1.34E-10 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.61|P-value:5.88E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:16.30|P-value:6.88E-68 ID:SGTC_396|Compound:dithiazanine|FD-Score:5.64|P-value:8.84E-10 ID:SGTC_397|Compound:arbidol|FD-Score:3.22|P-value:2.92E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.43|P-value:1.27E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.31|P-value:2.02E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.33|P-value:1.90E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.66|P-value:4.67E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:-2.92|P-value:9.66E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:2.89|P-value:9.99E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.72|P-value:3.57E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.79|P-value:2.81E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:3.38|P-value:1.56E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.10|P-value:4.77E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.13|P-value:4.18E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.56|P-value:7.68E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.13|P-value:4.36E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.43|P-value:1.26E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.70|P-value:3.87E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.33|P-value:1.87E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.49|P-value:9.65E-5 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.19|P-value:3.27E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:2.98|P-value:7.25E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.55|P-value:8.17E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:-3.39|P-value:1.56E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.04|P-value:5.80E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.21|P-value:3.12E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.00|P-value:1.01E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.98|P-value:7.80E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.38|P-value:5.85E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.00|P-value:1.05E-5 ID:SGTC_1571|Compound:st070080|FD-Score:3.20|P-value:3.23E-4 ID:SGTC_1634|Compound:st006576|FD-Score:4.49|P-value:8.45E-7 ID:SGTC_1636|Compound:st007707|FD-Score:3.49|P-value:9.79E-5 ID:SGTC_1717|Compound:st033143|FD-Score:2.94|P-value:8.64E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.99|P-value:1.11E-5 ID:SGTC_1754|Compound:st042065|FD-Score:9.30|P-value:1.83E-23 ID:SGTC_1760|Compound:st045453|FD-Score:3.04|P-value:5.86E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.81|P-value:2.41E-5 ID:SGTC_2242|Compound:6630449|FD-Score:-3.02|P-value:6.59E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.91|P-value:1.50E-5 ID:SGTC_2281|Compound:7943571|FD-Score:2.94|P-value:8.55E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.73|P-value:3.62E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-5.32|P-value:7.93E-9 ID:SGTC_2323|Compound:6148992|FD-Score:-2.93|P-value:9.38E-4 ID:SGTC_2324|Compound:6149169|FD-Score:4.11|P-value:5.92E-6 ID:SGTC_2347|Compound:9049783|FD-Score:3.23|P-value:2.88E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:3.47|P-value:1.06E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.08|P-value:5.03E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.15|P-value:3.84E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.54|P-value:8.56E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.59|P-value:4.86E-7 ID:SGTC_2798|Compound:7813637|FD-Score:3.49|P-value:9.60E-5 ID:SGTC_2820|Compound:7989630|FD-Score:2.98|P-value:7.44E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.92|P-value:7.73E-8 ID:SGTC_2830|Compound:7992007|FD-Score:-3.43|P-value:1.32E-4 ID:SGTC_2834|Compound:9001755|FD-Score:2.95|P-value:8.06E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-3.12|P-value:4.63E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.91|P-value:1.49E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.25|P-value:2.59E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.12|P-value:4.30E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.07|P-value:3.22E-8 ID:SGTC_3158|Compound:9100007|FD-Score:-2.92|P-value:9.67E-4 ID:SGTC_3297|Compound:9117502|FD-Score:2.96|P-value:7.89E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:5.92|P-value:1.34E-10 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.61|P-value:5.88E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:16.30|P-value:6.88E-68 ID:SGTC_396|Compound:dithiazanine|FD-Score:5.64|P-value:8.84E-10 ID:SGTC_397|Compound:arbidol|FD-Score:3.22|P-value:2.92E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.43|P-value:1.27E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.31|P-value:2.02E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.33|P-value:1.90E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.66|P-value:4.67E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:-2.92|P-value:9.66E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:2.89|P-value:9.99E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.72|P-value:3.57E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.79|P-value:2.81E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:3.38|P-value:1.56E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.10|P-value:4.77E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.13|P-value:4.18E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.56|P-value:7.68E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.13|P-value:4.36E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.43|P-value:1.26E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.70|P-value:3.87E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.33|P-value:1.87E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.49|P-value:9.65E-5 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.19|P-value:3.27E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:2.98|P-value:7.25E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.55|P-value:8.17E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:-3.39|P-value:1.56E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.04|P-value:5.80E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.21|P-value:3.12E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.00|P-value:1.01E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.98|P-value:7.80E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.38|P-value:5.85E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.00|P-value:1.05E-5 ID:SGTC_1571|Compound:st070080|FD-Score:3.20|P-value:3.23E-4 ID:SGTC_1634|Compound:st006576|FD-Score:4.49|P-value:8.45E-7 ID:SGTC_1636|Compound:st007707|FD-Score:3.49|P-value:9.79E-5 ID:SGTC_1717|Compound:st033143|FD-Score:2.94|P-value:8.64E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.99|P-value:1.11E-5 ID:SGTC_1754|Compound:st042065|FD-Score:9.30|P-value:1.83E-23 ID:SGTC_1760|Compound:st045453|FD-Score:3.04|P-value:5.86E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.81|P-value:2.41E-5 ID:SGTC_2242|Compound:6630449|FD-Score:-3.02|P-value:6.59E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.91|P-value:1.50E-5 ID:SGTC_2281|Compound:7943571|FD-Score:2.94|P-value:8.55E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.73|P-value:3.62E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-5.32|P-value:7.93E-9 ID:SGTC_2323|Compound:6148992|FD-Score:-2.93|P-value:9.38E-4 ID:SGTC_2324|Compound:6149169|FD-Score:4.11|P-value:5.92E-6 ID:SGTC_2347|Compound:9049783|FD-Score:3.23|P-value:2.88E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:3.47|P-value:1.06E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.08|P-value:5.03E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.15|P-value:3.84E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.54|P-value:8.56E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.59|P-value:4.86E-7 ID:SGTC_2798|Compound:7813637|FD-Score:3.49|P-value:9.60E-5 ID:SGTC_2820|Compound:7989630|FD-Score:2.98|P-value:7.44E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.92|P-value:7.73E-8 ID:SGTC_2830|Compound:7992007|FD-Score:-3.43|P-value:1.32E-4 ID:SGTC_2834|Compound:9001755|FD-Score:2.95|P-value:8.06E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-3.12|P-value:4.63E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.91|P-value:1.49E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.25|P-value:2.59E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.12|P-value:4.30E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.07|P-value:3.22E-8 ID:SGTC_3158|Compound:9100007|FD-Score:-2.92|P-value:9.67E-4 ID:SGTC_3297|Compound:9117502|FD-Score:2.96|P-value:7.89E-4

Top fitness defect scores for YGL077C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_221 trifluoperazine 16.30 10.3 µM 6.88E-68 NEO1-PIK1 19 4.54E-60
2 SGTC_1754 st042065 9.30 16.1 µM 1.83E-23 NEO1-PIK1 36 6.93E-21
3 SGTC_16 erodoxin 5.92 22.8 µM 1.34E-10 unfolded protein response 27 1.57E-9
4 SGTC_396 dithiazanine 5.64 1.2 µM 8.84E-10 2 8.32E-9
5 SGTC_3152 9099253 5.07 49.5 µM 3.22E-8 NEO1-PIK1 78 2.00E-7
6 SGTC_2829 7992743 4.92 58.4 µM 7.73E-8 17 4.33E-7
7 SGTC_2688 kanamycin b 4.59 96.7 µM 4.86E-7 calcium & mitochondrial duress 285 2.20E-6
8 SGTC_1634 st006576 4.49 41.0 µM 8.45E-7 TSC3-RPN4 12 3.59E-6
9 SGTC_2324 6149169 4.11 200.0 µM 5.92E-6 18 2.01E-5
10 SGTC_1369 1866-0067 4.00 208.0 µM 1.01E-5 RPP1 & pyrimidine depletion 37 3.23E-5
11 SGTC_2880 9042983 3.91 58.4 µM 1.49E-5 fatty acid desaturase (OLE1) 28 4.55E-5
12 SGTC_2249 haloperidol 3.91 116.4 µM 1.50E-5 ergosterol depletion effects on membrane 116 4.58E-5
13 SGTC_1818 st052136 3.81 56.3 µM 2.41E-5 NEO1-PIK1 59 6.97E-5
14 SGTC_682 0kpi-0099 3.72 17.0 µM 3.57E-5 78 9.88E-5
15 SGTC_1034 k072-0165 3.70 12.7 µM 3.87E-5 Golgi 27 1.06E-4
16 SGTC_535 2293-4129 3.66 48.2 µM 4.67E-5 NEO1 74 1.25E-4
17 SGTC_46 0329-0187a 3.61 2.2 µM 5.88E-5 89 1.54E-4
18 SGTC_2798 7813637 3.49 45.5 µM 9.60E-5 50 2.37E-4
19 SGTC_1079 idarubicin 3.49 2.4 µM 9.65E-5 DNA damage response 33 2.39E-4
20 SGTC_1636 st007707 3.49 68.9 µM 9.79E-5 63 2.41E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.405 1.21E-132 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.380 3.71E-115 YNL295W_p YNL295W_p hom Putative protein of unknown function
0.349 1.06E-96 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.319 4.21E-80 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.300 6.59E-71 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.298 1.13E-69 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.297 2.46E-69 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.295 1.62E-68 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.279 4.12E-61 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.278 2.16E-60 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.275 3.69E-59 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.272 3.81E-58 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.260 9.28E-53 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.251 1.63E-49 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.251 2.64E-49 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval