YGL081W_p

Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL081W / YGL081W

Click on Significant Values for Screen Details ID:SGTC_280|Compound:3448-3607|FD-Score:3.09|P-value:1.37E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.06|P-value:1.26E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.09|P-value:1.13E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.09|P-value:1.12E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-2.70|P-value:6.28E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-2.76|P-value:4.91E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:6.31|P-value:4.48E-14 ID:SGTC_613|Compound:3914-0030|FD-Score:-5.53|P-value:2.22E-11 ID:SGTC_614|Compound:0462-0418|FD-Score:-6.63|P-value:1.49E-15 ID:SGTC_630|Compound:4356-0227|FD-Score:-2.83|P-value:3.49E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.11|P-value:1.26E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.14|P-value:1.08E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:2.84|P-value:4.17E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.22|P-value:2.46E-10 ID:SGTC_774|Compound:k060-0086|FD-Score:3.00|P-value:2.08E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:2.72|P-value:7.05E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:2.67|P-value:8.43E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.50|P-value:1.45E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-5.90|P-value:1.03E-12 ID:SGTC_1103|Compound:duloxetine|FD-Score:2.92|P-value:2.96E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.47|P-value:3.57E-11 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.31|P-value:4.93E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.47|P-value:6.67E-8 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.77|P-value:5.73E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.65|P-value:8.49E-6 ID:SGTC_2046|Compound:4110841|FD-Score:4.60|P-value:2.93E-8 ID:SGTC_2053|Compound:5265679|FD-Score:-3.04|P-value:1.42E-4 ID:SGTC_2086|Compound:5274770|FD-Score:-2.98|P-value:1.87E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.10|P-value:1.06E-4 ID:SGTC_2096|Compound:5468907|FD-Score:2.81|P-value:4.72E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.57|P-value:1.29E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-3.96|P-value:1.13E-6 ID:SGTC_2312|Compound:7706453|FD-Score:-3.18|P-value:7.22E-5 ID:SGTC_2315|Compound:7733312|FD-Score:-3.77|P-value:3.35E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-3.25|P-value:5.18E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-4.34|P-value:1.14E-7 ID:SGTC_2364|Compound:9055074|FD-Score:2.93|P-value:2.88E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-2.96|P-value:2.02E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-4.44|P-value:6.05E-8 ID:SGTC_2374|Compound:9071832|FD-Score:3.32|P-value:4.74E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.70|P-value:1.06E-8 ID:SGTC_2601|Compound:securinine|FD-Score:-3.42|P-value:2.20E-5 ID:SGTC_280|Compound:3448-3607|FD-Score:3.09|P-value:1.37E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.06|P-value:1.26E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.09|P-value:1.13E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.09|P-value:1.12E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-2.70|P-value:6.28E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-2.76|P-value:4.91E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:6.31|P-value:4.48E-14 ID:SGTC_613|Compound:3914-0030|FD-Score:-5.53|P-value:2.22E-11 ID:SGTC_614|Compound:0462-0418|FD-Score:-6.63|P-value:1.49E-15 ID:SGTC_630|Compound:4356-0227|FD-Score:-2.83|P-value:3.49E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.11|P-value:1.26E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.14|P-value:1.08E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:2.84|P-value:4.17E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.22|P-value:2.46E-10 ID:SGTC_774|Compound:k060-0086|FD-Score:3.00|P-value:2.08E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:2.72|P-value:7.05E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:2.67|P-value:8.43E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.50|P-value:1.45E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-5.90|P-value:1.03E-12 ID:SGTC_1103|Compound:duloxetine|FD-Score:2.92|P-value:2.96E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.47|P-value:3.57E-11 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.31|P-value:4.93E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.47|P-value:6.67E-8 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.77|P-value:5.73E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.65|P-value:8.49E-6 ID:SGTC_2046|Compound:4110841|FD-Score:4.60|P-value:2.93E-8 ID:SGTC_2053|Compound:5265679|FD-Score:-3.04|P-value:1.42E-4 ID:SGTC_2086|Compound:5274770|FD-Score:-2.98|P-value:1.87E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.10|P-value:1.06E-4 ID:SGTC_2096|Compound:5468907|FD-Score:2.81|P-value:4.72E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.57|P-value:1.29E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-3.96|P-value:1.13E-6 ID:SGTC_2312|Compound:7706453|FD-Score:-3.18|P-value:7.22E-5 ID:SGTC_2315|Compound:7733312|FD-Score:-3.77|P-value:3.35E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-3.25|P-value:5.18E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-4.34|P-value:1.14E-7 ID:SGTC_2364|Compound:9055074|FD-Score:2.93|P-value:2.88E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-2.96|P-value:2.02E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-4.44|P-value:6.05E-8 ID:SGTC_2374|Compound:9071832|FD-Score:3.32|P-value:4.74E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.70|P-value:1.06E-8 ID:SGTC_2601|Compound:securinine|FD-Score:-3.42|P-value:2.20E-5

Top fitness defect scores for YGL081W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_457 grayanotoxin iii 6.31 135.0 µM 4.48E-14 20 1.39E-10
2 SGTC_2046 4110841 4.60 106.0 µM 2.93E-8 iron homeostasis 16 2.15E-6
3 SGTC_1230 0170-0365 4.47 3.8 µM 6.67E-8 endomembrane recycling 46 3.89E-6
4 SGTC_1758 st042942 3.65 75.2 µM 8.49E-6 30 1.31E-4
5 SGTC_2297 7971671 3.57 152.3 µM 1.29E-5 RNA processing & uracil transport 39 1.77E-4
6 SGTC_2374 9071832 3.32 200.0 µM 4.74E-5 endomembrane recycling 21 4.58E-4
7 SGTC_1138 3761-0006 3.31 1.0 µM 4.93E-5 20 4.71E-4
8 SGTC_737 1950-0117 3.14 57.9 µM 1.08E-4 49 8.37E-4
9 SGTC_643 k048-0106 3.11 28.4 µM 1.26E-4 RSC & ERG11 28 9.37E-4
10 SGTC_280 3448-3607 3.09 3.0 µM 1.37E-4 60S ribosome export 27 9.93E-4
11 SGTC_774 k060-0086 3.00 136.0 µM 2.08E-4 58 0.00135
12 SGTC_2364 9055074 2.93 200.0 µM 2.88E-4 62 0.00171
13 SGTC_1103 duloxetine 2.92 36.1 µM 2.96E-4 85 0.00175
14 SGTC_749 1000-0129 2.84 128.0 µM 4.17E-4 amide catabolism 77 0.00225
15 SGTC_2096 5468907 2.81 200.0 µM 4.72E-4 49 0.00246
16 SGTC_1291 0993-0025 2.77 5.8 µM 5.73E-4 52 0.00284
17 SGTC_895 0964-0006 2.72 13.7 µM 7.05E-4 69 0.00331
18 SGTC_896 0964-0007 2.67 44.5 µM 8.43E-4 61 0.00377
19 SGTC_3018 9082602 2.61 49.5 µM 0.00110 113 0.00458
20 SGTC_27 0485-0001 2.59 32.6 µM 0.00117 RPP1 & pyrimidine depletion 53 0.00481

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.313 3.74E-77 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.280 1.65E-61 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.276 6.62E-60 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.272 7.30E-58 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.271 1.34E-57 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.267 1.05E-55 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.245 6.23E-47 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.243 3.87E-46 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.226 4.32E-40 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.212 2.69E-35 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.210 8.51E-35 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.201 6.63E-32 YML011C RAD33 hom Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.200 1.77E-31 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.199 2.56E-31 YDR099W BMH2 hom 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.193 1.56E-29 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins