YGL083W / SCY1

Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL083W / SCY1

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-2.90|P-value:5.94E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:3.11|P-value:3.16E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:-2.91|P-value:5.74E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.82|P-value:5.14E-8 ID:SGTC_318|Compound:1488-0629|FD-Score:-2.85|P-value:7.21E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.78|P-value:1.53E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.41|P-value:1.14E-9 ID:SGTC_449|Compound:xestospongin c|FD-Score:2.95|P-value:5.77E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:2.85|P-value:8.68E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:2.89|P-value:7.50E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:2.86|P-value:8.24E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:4.56|P-value:2.43E-7 ID:SGTC_734|Compound:2023-0417|FD-Score:3.62|P-value:3.27E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:3.21|P-value:2.04E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:2.85|P-value:8.77E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:14.30|P-value:2.29E-56 ID:SGTC_998|Compound:3996-0085|FD-Score:4.29|P-value:1.11E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.40|P-value:9.22E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:2.93|P-value:6.30E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:2.81|P-value:9.96E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.31|P-value:9.89E-7 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.95|P-value:2.44E-8 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.19|P-value:2.28E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.06|P-value:3.84E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.51|P-value:5.60E-5 ID:SGTC_1714|Compound:st033236|FD-Score:9.27|P-value:6.09E-25 ID:SGTC_1754|Compound:st042065|FD-Score:6.02|P-value:1.52E-11 ID:SGTC_1793|Compound:st048256|FD-Score:3.13|P-value:2.83E-4 ID:SGTC_1818|Compound:st052136|FD-Score:6.05|P-value:1.18E-11 ID:SGTC_1895|Compound:st058434|FD-Score:3.68|P-value:2.56E-5 ID:SGTC_1922|Compound:5578187|FD-Score:-4.35|P-value:6.27E-7 ID:SGTC_1924|Compound:st058459|FD-Score:4.10|P-value:3.16E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.15|P-value:2.64E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.47|P-value:5.36E-5 ID:SGTC_1949|Compound:st076024|FD-Score:4.20|P-value:1.87E-6 ID:SGTC_2046|Compound:4110841|FD-Score:3.18|P-value:2.30E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.10|P-value:2.70E-4 ID:SGTC_2260|Compound:7964312|FD-Score:2.86|P-value:8.22E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.85|P-value:7.42E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.20|P-value:2.11E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.09|P-value:2.58E-6 ID:SGTC_2693|Compound:st077581|FD-Score:3.78|P-value:1.54E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:2.91|P-value:6.76E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-4.41|P-value:4.46E-7 ID:SGTC_2932|Compound:9016711|FD-Score:5.32|P-value:2.11E-9 ID:SGTC_2933|Compound:9026794|FD-Score:-3.22|P-value:1.66E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.80|P-value:1.15E-5 ID:SGTC_2967|Compound:9089538|FD-Score:2.82|P-value:9.59E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.19|P-value:5.18E-9 ID:SGTC_3065|Compound:9113888|FD-Score:3.65|P-value:2.97E-5 ID:SGTC_3152|Compound:9099253|FD-Score:5.71|P-value:1.42E-10 ID:SGTC_3207|Compound:9114163|FD-Score:3.80|P-value:1.39E-5 ID:SGTC_3301|Compound:9125354|FD-Score:-3.80|P-value:1.12E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-2.90|P-value:5.94E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:3.11|P-value:3.16E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:-2.91|P-value:5.74E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.82|P-value:5.14E-8 ID:SGTC_318|Compound:1488-0629|FD-Score:-2.85|P-value:7.21E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.78|P-value:1.53E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.41|P-value:1.14E-9 ID:SGTC_449|Compound:xestospongin c|FD-Score:2.95|P-value:5.77E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:2.85|P-value:8.68E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:2.89|P-value:7.50E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:2.86|P-value:8.24E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:4.56|P-value:2.43E-7 ID:SGTC_734|Compound:2023-0417|FD-Score:3.62|P-value:3.27E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:3.21|P-value:2.04E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:2.85|P-value:8.77E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:14.30|P-value:2.29E-56 ID:SGTC_998|Compound:3996-0085|FD-Score:4.29|P-value:1.11E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.40|P-value:9.22E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:2.93|P-value:6.30E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:2.81|P-value:9.96E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.31|P-value:9.89E-7 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.95|P-value:2.44E-8 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.19|P-value:2.28E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.06|P-value:3.84E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.51|P-value:5.60E-5 ID:SGTC_1714|Compound:st033236|FD-Score:9.27|P-value:6.09E-25 ID:SGTC_1754|Compound:st042065|FD-Score:6.02|P-value:1.52E-11 ID:SGTC_1793|Compound:st048256|FD-Score:3.13|P-value:2.83E-4 ID:SGTC_1818|Compound:st052136|FD-Score:6.05|P-value:1.18E-11 ID:SGTC_1895|Compound:st058434|FD-Score:3.68|P-value:2.56E-5 ID:SGTC_1922|Compound:5578187|FD-Score:-4.35|P-value:6.27E-7 ID:SGTC_1924|Compound:st058459|FD-Score:4.10|P-value:3.16E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.15|P-value:2.64E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.47|P-value:5.36E-5 ID:SGTC_1949|Compound:st076024|FD-Score:4.20|P-value:1.87E-6 ID:SGTC_2046|Compound:4110841|FD-Score:3.18|P-value:2.30E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.10|P-value:2.70E-4 ID:SGTC_2260|Compound:7964312|FD-Score:2.86|P-value:8.22E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.85|P-value:7.42E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.20|P-value:2.11E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.09|P-value:2.58E-6 ID:SGTC_2693|Compound:st077581|FD-Score:3.78|P-value:1.54E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:2.91|P-value:6.76E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-4.41|P-value:4.46E-7 ID:SGTC_2932|Compound:9016711|FD-Score:5.32|P-value:2.11E-9 ID:SGTC_2933|Compound:9026794|FD-Score:-3.22|P-value:1.66E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.80|P-value:1.15E-5 ID:SGTC_2967|Compound:9089538|FD-Score:2.82|P-value:9.59E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.19|P-value:5.18E-9 ID:SGTC_3065|Compound:9113888|FD-Score:3.65|P-value:2.97E-5 ID:SGTC_3152|Compound:9099253|FD-Score:5.71|P-value:1.42E-10 ID:SGTC_3207|Compound:9114163|FD-Score:3.80|P-value:1.39E-5 ID:SGTC_3301|Compound:9125354|FD-Score:-3.80|P-value:1.12E-5

Top fitness defect scores for YGL083W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 14.30 1.8 µM 2.29E-56 6 2.04E-46
2 SGTC_1714 st033236 9.27 13.6 µM 6.09E-25 1 9.46E-21
3 SGTC_1818 st052136 6.05 56.3 µM 1.18E-11 NEO1-PIK1 13 7.17E-10
4 SGTC_1754 st042065 6.02 16.1 µM 1.52E-11 NEO1-PIK1 99 8.86E-10
5 SGTC_3152 9099253 5.71 49.5 µM 1.42E-10 NEO1-PIK1 63 5.56E-9
6 SGTC_445 e6 berbamine 5.41 66.0 µM 1.14E-9 NEO1-PIK1 43 3.07E-8
7 SGTC_2932 9016711 5.32 44.5 µM 2.11E-9 20 5.10E-8
8 SGTC_3037 9091026 5.19 49.5 µM 5.18E-9 NEO1-PIK1 69 1.06E-7
9 SGTC_1333 1482-0047 4.95 286.0 µM 2.44E-8 8 3.81E-7
10 SGTC_221 trifluoperazine 4.82 10.3 µM 5.14E-8 NEO1-PIK1 170 7.04E-7
11 SGTC_689 0833-0039 4.56 98.0 µM 2.43E-7 ergosterol depletion effects on membrane 23 2.53E-6
12 SGTC_1330 1469-0054 4.31 61.8 µM 9.89E-7 iron homeostasis 11 8.05E-6
13 SGTC_998 3996-0085 4.29 177.0 µM 1.11E-6 12 8.83E-6
14 SGTC_1949 st076024 4.20 69.1 µM 1.87E-6 17 1.36E-5
15 SGTC_1924 st058459 4.10 75.1 µM 3.16E-6 8 2.10E-5
16 SGTC_3207 9114163 3.80 49.5 µM 1.39E-5 33 7.15E-5
17 SGTC_408 cantharidin 3.78 100.0 µM 1.53E-5 cell wall signaling 27 7.73E-5
18 SGTC_2693 st077581 3.78 40.7 µM 1.54E-5 42 7.77E-5
19 SGTC_1895 st058434 3.68 18.3 µM 2.56E-5 18 1.18E-4
20 SGTC_3065 9113888 3.65 49.5 µM 2.97E-5 33 1.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.461 1.17E-175 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.353 5.41E-99 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.332 2.57E-87 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.307 4.14E-74 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.305 3.53E-73 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.292 8.72E-67 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.255 5.40E-51 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.238 2.25E-44 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.232 2.55E-42 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.231 9.27E-42 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.231 1.07E-41 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.225 9.53E-40 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.215 1.80E-36 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.214 6.12E-36 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.214 6.07E-36 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C