YGL096W / TOS8

Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL096W / TOS8

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.01|P-value:4.90E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.29|P-value:1.46E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.35|P-value:1.13E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-4.05|P-value:4.13E-6 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.73|P-value:2.05E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.77|P-value:1.82E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:4.38|P-value:8.17E-7 ID:SGTC_616|Compound:4092-0450|FD-Score:2.83|P-value:9.92E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.56|P-value:4.81E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:3.14|P-value:2.92E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:2.84|P-value:9.44E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.48|P-value:7.00E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:8.26|P-value:6.66E-20 ID:SGTC_1000|Compound:4048-0884|FD-Score:-4.05|P-value:4.20E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:-2.89|P-value:7.22E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.70|P-value:1.15E-7 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.74|P-value:2.09E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.04|P-value:4.36E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.83|P-value:9.23E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.31|P-value:1.48E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:2.86|P-value:8.94E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:2.83|P-value:9.70E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:2.99|P-value:5.41E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.86|P-value:1.06E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.02|P-value:4.68E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.00|P-value:4.80E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.30|P-value:1.39E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.05|P-value:4.55E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.30|P-value:1.38E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.11|P-value:3.28E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.26|P-value:1.81E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.04|P-value:4.48E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.26|P-value:1.79E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.59|P-value:4.16E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.94|P-value:7.96E-6 ID:SGTC_3319|Compound:9138450|FD-Score:2.92|P-value:7.02E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-2.89|P-value:7.19E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.01|P-value:4.90E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.29|P-value:1.46E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.35|P-value:1.13E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-4.05|P-value:4.13E-6 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.73|P-value:2.05E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.77|P-value:1.82E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:4.38|P-value:8.17E-7 ID:SGTC_616|Compound:4092-0450|FD-Score:2.83|P-value:9.92E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.56|P-value:4.81E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:3.14|P-value:2.92E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:2.84|P-value:9.44E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.48|P-value:7.00E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:8.26|P-value:6.66E-20 ID:SGTC_1000|Compound:4048-0884|FD-Score:-4.05|P-value:4.20E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:-2.89|P-value:7.22E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.70|P-value:1.15E-7 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.74|P-value:2.09E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.04|P-value:4.36E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.83|P-value:9.23E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.31|P-value:1.48E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:2.86|P-value:8.94E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:2.83|P-value:9.70E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:2.99|P-value:5.41E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.86|P-value:1.06E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.02|P-value:4.68E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.00|P-value:4.80E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.30|P-value:1.39E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.05|P-value:4.55E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.30|P-value:1.38E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.11|P-value:3.28E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.26|P-value:1.81E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.04|P-value:4.48E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.26|P-value:1.79E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.59|P-value:4.16E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.94|P-value:7.96E-6 ID:SGTC_3319|Compound:9138450|FD-Score:2.92|P-value:7.02E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-2.89|P-value:7.19E-4

Top fitness defect scores for YGL096W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 8.26 1.8 µM 6.66E-20 19 7.23E-17
2 SGTC_612 0302-0167 4.38 22.4 µM 8.17E-7 copper-dependent oxidative stress 24 6.01E-6
3 SGTC_1913 st060213 4.05 96.1 µM 4.55E-6 28 2.54E-5
4 SGTC_3309 9129340 3.94 25.8 µM 7.96E-6 15 4.05E-5
5 SGTC_604 1000-0114 3.77 314.0 µM 1.82E-5 25 8.12E-5
6 SGTC_1121 fusaric acid 3.74 630.5 nM 2.09E-5 40 9.11E-5
7 SGTC_2796 7949634 3.59 45.5 µM 4.16E-5 28 1.62E-4
8 SGTC_774 k060-0086 3.56 136.0 µM 4.81E-5 29 1.83E-4
9 SGTC_953 1188-0045 3.48 9.7 µM 7.00E-5 60S ribosome export 42 2.51E-4
10 SGTC_1310 1188-0297 3.31 994.0 nM 1.48E-4 azole & statin 53 4.71E-4
11 SGTC_2691 st077356 3.26 60.2 µM 1.79E-4 62 5.53E-4
12 SGTC_2393 9031399 3.26 185.9 µM 1.81E-4 RNA processing & uracil transport 59 5.59E-4
13 SGTC_890 0929-0006 3.14 47.2 µM 2.92E-4 40 8.36E-4
14 SGTC_2347 9049783 3.11 174.8 µM 3.28E-4 66 9.23E-4
15 SGTC_1256 0570-0116 3.04 285.0 µM 4.36E-4 56 0.00117
16 SGTC_2421 5690543 3.04 90.7 µM 4.48E-4 57 0.00120
17 SGTC_1725 st036284 3.02 20.6 µM 4.68E-4 69 0.00125
18 SGTC_65 0798-0905 3.01 35.0 µM 4.90E-4 calcium & mitochondrial duress 162 0.00130
19 SGTC_1434 4073-0095 2.99 163.0 µM 5.41E-4 44 0.00141
20 SGTC_3319 9138450 2.92 16.8 µM 7.02E-4 63 0.00175

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.403 2.66E-131 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.363 5.63E-105 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.348 6.29E-96 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.305 2.24E-73 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.266 1.90E-55 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.264 2.16E-54 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.249 1.35E-48 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.231 7.36E-42 YDR242W AMD2 hom Putative amidase
0.230 2.39E-41 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.223 6.45E-39 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.217 3.55E-37 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.215 1.44E-36 YML084W_d YML084W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.215 2.15E-36 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.213 8.11E-36 YDL161W ENT1 hom Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.213 1.11E-35 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress