YGL110C / CUE3

Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL110C / CUE3

Click on Significant Values for Screen Details ID:SGTC_160|Compound:3453-0671|FD-Score:-3.76|P-value:9.89E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.27|P-value:6.62E-7 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.14|P-value:1.82E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:2.76|P-value:9.29E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.48|P-value:4.45E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:2.96|P-value:4.21E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.46|P-value:4.78E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:2.94|P-value:4.64E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.29|P-value:1.05E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.26|P-value:1.19E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.62|P-value:2.27E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:-2.98|P-value:3.58E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.90|P-value:4.95E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.16|P-value:1.85E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.86|P-value:5.96E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:2.76|P-value:9.34E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:2.77|P-value:9.08E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.80|P-value:9.31E-6 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.59|P-value:2.61E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.12|P-value:2.20E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.67|P-value:1.62E-5 ID:SGTC_1850|Compound:st056238|FD-Score:-2.92|P-value:4.54E-4 ID:SGTC_1906|Compound:st060206|FD-Score:2.85|P-value:6.73E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.78|P-value:1.02E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.56|P-value:2.98E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.85|P-value:7.30E-6 ID:SGTC_2238|Compound:6671620|FD-Score:-2.96|P-value:4.00E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.82|P-value:2.65E-8 ID:SGTC_2241|Compound:6772625|FD-Score:-3.01|P-value:3.23E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-4.64|P-value:7.25E-8 ID:SGTC_2348|Compound:9022543|FD-Score:3.06|P-value:2.83E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.34|P-value:7.44E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:2.88|P-value:5.93E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:2.90|P-value:5.44E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:2.90|P-value:5.39E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.77|P-value:8.24E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:7.31|P-value:7.75E-17 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.63|P-value:1.90E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-5.15|P-value:2.65E-9 ID:SGTC_2602|Compound:kawain|FD-Score:3.32|P-value:9.33E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.98|P-value:3.63E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.69|P-value:6.16E-8 ID:SGTC_2869|Compound:9037858|FD-Score:-2.87|P-value:5.70E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.76|P-value:9.89E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.27|P-value:6.62E-7 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.14|P-value:1.82E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:2.76|P-value:9.29E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.48|P-value:4.45E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:2.96|P-value:4.21E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.46|P-value:4.78E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:2.94|P-value:4.64E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.29|P-value:1.05E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.26|P-value:1.19E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.62|P-value:2.27E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:-2.98|P-value:3.58E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.90|P-value:4.95E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.16|P-value:1.85E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.86|P-value:5.96E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:2.76|P-value:9.34E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:2.77|P-value:9.08E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.80|P-value:9.31E-6 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.59|P-value:2.61E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.12|P-value:2.20E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.67|P-value:1.62E-5 ID:SGTC_1850|Compound:st056238|FD-Score:-2.92|P-value:4.54E-4 ID:SGTC_1906|Compound:st060206|FD-Score:2.85|P-value:6.73E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.78|P-value:1.02E-5 ID:SGTC_2125|Compound:5246583|FD-Score:3.56|P-value:2.98E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.85|P-value:7.30E-6 ID:SGTC_2238|Compound:6671620|FD-Score:-2.96|P-value:4.00E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.82|P-value:2.65E-8 ID:SGTC_2241|Compound:6772625|FD-Score:-3.01|P-value:3.23E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-4.64|P-value:7.25E-8 ID:SGTC_2348|Compound:9022543|FD-Score:3.06|P-value:2.83E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.34|P-value:7.44E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:2.88|P-value:5.93E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:2.90|P-value:5.44E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:2.90|P-value:5.39E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.77|P-value:8.24E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:7.31|P-value:7.75E-17 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.63|P-value:1.90E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-5.15|P-value:2.65E-9 ID:SGTC_2602|Compound:kawain|FD-Score:3.32|P-value:9.33E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.98|P-value:3.63E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.69|P-value:6.16E-8 ID:SGTC_2869|Compound:9037858|FD-Score:-2.87|P-value:5.70E-4

Top fitness defect scores for YGL110C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2593 nobiletin 7.31 86.2 µM 7.75E-17 4 1.32E-13
2 SGTC_2239 6685329 4.82 187.6 µM 2.65E-8 10 7.01E-7
3 SGTC_2831 7999036 4.69 19.5 µM 6.16E-8 24 1.37E-6
4 SGTC_2130 NSC 7 3.85 2.5 µM 7.30E-6 copper-dependent oxidative stress 28 6.01E-5
5 SGTC_910 3454-3003 3.80 490.0 µM 9.31E-6 21 7.29E-5
6 SGTC_1948 st076329 3.78 66.6 µM 1.02E-5 36 7.82E-5
7 SGTC_656 4090-1979 3.62 187.0 µM 2.27E-5 28 1.48E-4
8 SGTC_1206 3978-0017 3.59 132.0 µM 2.61E-5 ERG2 49 1.66E-4
9 SGTC_2125 5246583 3.56 200.0 µM 2.98E-5 tubulin folding & SWR complex 57 1.84E-4
10 SGTC_270 tamoxifen 3.48 5.5 µM 4.45E-5 NEO1 53 2.53E-4
11 SGTC_357 1325-0123 3.46 420.0 µM 4.78E-5 13 2.68E-4
12 SGTC_2602 kawain 3.32 100.0 µM 9.33E-5 52 4.56E-4
13 SGTC_359 0081-0058 3.29 15.9 µM 1.05E-4 60S ribosome export 81 4.99E-4
14 SGTC_361 000s-0510 3.26 1.4 µM 1.19E-4 61 5.51E-4
15 SGTC_700 3453-2283 3.16 142.0 µM 1.85E-4 amide catabolism 64 7.87E-4
16 SGTC_1432 4049-0298 3.12 68.4 µM 2.20E-4 27 9.04E-4
17 SGTC_2348 9022543 3.06 33.4 µM 2.83E-4 mitochondrial processes 60 0.00110
18 SGTC_356 1634-0012 2.96 32.5 µM 4.21E-4 73 0.00152
19 SGTC_358 0075-0058 2.94 9.4 µM 4.64E-4 138 0.00164
20 SGTC_2503 beta-caryophyllene alcohol 2.90 24.7 µM 5.39E-4 37 0.00185

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.238 1.59E-44 YFR012W DCV1 hom Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication
0.186 2.25E-27 YGL249W ZIP2 hom Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.158 2.72E-20 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.149 4.63E-18 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.147 1.18E-17 YMR196W_p YMR196W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
0.145 2.90E-17 YCR004C YCP4 hom Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.142 1.32E-16 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.141 1.78E-16 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
0.141 2.51E-16 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.126 2.66E-13 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.124 6.52E-13 YBR104W YMC2 hom Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication
0.118 6.49E-12 YOR376W_d YOR376W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
0.117 9.89E-12 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.116 1.88E-11 YHR132W-A IGO2 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p
0.111 1.02E-10 YFL048C EMP47 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport