HIPHOP chemogenomics database
YGL111W / NSA1 
Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YGL111W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.123 | 8.65E-13 | YER043C | SAH1 | het | S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor |
| 0.121 | 2.17E-12 | YLR195C | NMT1 | het | N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction |
| 0.113 | 4.93E-11 | YMR049C | ERB1 | het | Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 |
| 0.112 | 8.94E-11 | YDL031W | DBP10 | het | Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis |
| 0.105 | 1.08E-9 | YGR177C | ATF2 | hom | Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking |
| 0.103 | 2.23E-9 | YDR482C | CWC21 | hom | Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p |
| 0.102 | 3.61E-9 | YKL161C | KDX1 | hom | Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p |
| 0.100 | 6.43E-9 | YGR069W_d | YGR069W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.099 | 9.73E-9 | YDR302W | GPI11 | het | ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog |
| 0.097 | 1.83E-8 | YGL152C_d | YGL152C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W |
| 0.097 | 1.92E-8 | YML047C | PRM6 | hom | Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family |
| 0.097 | 1.98E-8 | YDR464W | SPP41 | het | Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 |
| 0.096 | 2.88E-8 | YBR155W | CNS1 | het | TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion |
| 0.095 | 3.98E-8 | YFL047W | RGD2 | hom | GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress |
| 0.093 | 6.70E-8 | YGR248W | SOL4 | hom | 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication |