YGL117W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL117W / YGL117W

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:4.21|P-value:3.24E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:6.96|P-value:7.56E-9 ID:SGTC_25|Compound:0118-0223|FD-Score:-4.59|P-value:7.68E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:6.77|P-value:1.82E-8 ID:SGTC_51|Compound:1013-0126|FD-Score:4.07|P-value:4.88E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.83|P-value:9.73E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.44|P-value:1.62E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:4.54|P-value:1.19E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:4.12|P-value:4.23E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:4.64|P-value:8.44E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:5.12|P-value:1.63E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:4.25|P-value:2.90E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:5.99|P-value:5.74E-7 ID:SGTC_167|Compound:3672-0051|FD-Score:10.20|P-value:4.48E-17 ID:SGTC_176|Compound:1486-1328|FD-Score:9.07|P-value:7.46E-14 ID:SGTC_180|Compound:1486-1293|FD-Score:8.59|P-value:1.38E-12 ID:SGTC_194|Compound:1486-1323|FD-Score:5.94|P-value:7.07E-7 ID:SGTC_205|Compound:1486-1330|FD-Score:7.58|P-value:3.49E-10 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-4.30|P-value:1.91E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:4.02|P-value:5.70E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:14.70|P-value:3.05E-33 ID:SGTC_298|Compound:1391-0729|FD-Score:5.85|P-value:9.95E-7 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.88|P-value:8.54E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.36|P-value:2.06E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.83|P-value:9.66E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:6.05|P-value:4.52E-7 ID:SGTC_470|Compound:aa-861|FD-Score:4.23|P-value:3.07E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:5.32|P-value:8.02E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:4.98|P-value:2.66E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:5.32|P-value:7.97E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:-3.81|P-value:8.22E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.83|P-value:4.50E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:7.16|P-value:2.92E-9 ID:SGTC_585|Compound:0kpi-0023|FD-Score:8.00|P-value:3.72E-11 ID:SGTC_596|Compound:1155-0152|FD-Score:4.49|P-value:1.36E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:5.16|P-value:1.44E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.61|P-value:9.31E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:4.36|P-value:2.08E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:3.95|P-value:6.95E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.92|P-value:7.48E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:6.97|P-value:7.43E-9 ID:SGTC_792|Compound:4534-1957|FD-Score:6.52|P-value:5.71E-8 ID:SGTC_823|Compound:0417-1665|FD-Score:3.87|P-value:8.61E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:4.75|P-value:5.97E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:8.03|P-value:3.16E-11 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.79|P-value:8.61E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.93|P-value:3.23E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.95|P-value:7.00E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.08|P-value:4.78E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.19|P-value:3.42E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:6.77|P-value:1.85E-8 ID:SGTC_1219|Compound:1469-0211|FD-Score:4.42|P-value:1.68E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:6.53|P-value:5.47E-8 ID:SGTC_1245|Compound:0418-0076|FD-Score:6.20|P-value:2.40E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:5.78|P-value:1.34E-6 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.62|P-value:9.00E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.22|P-value:3.17E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:6.78|P-value:1.74E-8 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.50|P-value:6.46E-8 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.03|P-value:5.57E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:-3.82|P-value:7.89E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:6.39|P-value:1.04E-7 ID:SGTC_1427|Compound:4048-4900|FD-Score:6.97|P-value:7.24E-9 ID:SGTC_1455|Compound:4262-0120|FD-Score:4.80|P-value:4.99E-5 ID:SGTC_1482|Compound:3346-2049|FD-Score:5.01|P-value:2.40E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:4.45|P-value:1.53E-4 ID:SGTC_1516|Compound:st013856|FD-Score:-4.23|P-value:2.41E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.22|P-value:3.16E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:5.48|P-value:4.25E-6 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.13|P-value:1.60E-5 ID:SGTC_1636|Compound:st007707|FD-Score:3.93|P-value:7.34E-4 ID:SGTC_1649|Compound:st011737|FD-Score:4.83|P-value:4.43E-5 ID:SGTC_1655|Compound:st012546|FD-Score:4.57|P-value:1.07E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.62|P-value:8.88E-5 ID:SGTC_1697|Compound:st025554|FD-Score:4.99|P-value:2.62E-5 ID:SGTC_1715|Compound:st032160|FD-Score:4.25|P-value:2.90E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.87|P-value:8.75E-4 ID:SGTC_1757|Compound:st041620|FD-Score:5.83|P-value:1.12E-6 ID:SGTC_1824|Compound:st053723|FD-Score:4.71|P-value:6.74E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:5.10|P-value:1.75E-5 ID:SGTC_1881|Compound:5652484|FD-Score:5.61|P-value:2.65E-6 ID:SGTC_1882|Compound:5615643|FD-Score:3.85|P-value:9.23E-4 ID:SGTC_1921|Compound:5740136|FD-Score:5.26|P-value:9.70E-6 ID:SGTC_1933|Compound:st074711|FD-Score:6.70|P-value:2.58E-8 ID:SGTC_1937|Compound:st074714|FD-Score:8.20|P-value:1.28E-11 ID:SGTC_1952|Compound:st077036|FD-Score:6.67|P-value:2.93E-8 ID:SGTC_1975|Compound:st070967|FD-Score:3.83|P-value:9.79E-4 ID:SGTC_2175|Compound:5807670|FD-Score:5.47|P-value:4.56E-6 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:-4.18|P-value:2.79E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:7.39|P-value:9.02E-10 ID:SGTC_2340|Compound:7987427|FD-Score:4.04|P-value:5.37E-4 ID:SGTC_2384|Compound:9036245|FD-Score:4.61|P-value:9.29E-5 ID:SGTC_2403|Compound:6032726|FD-Score:7.27|P-value:1.72E-9 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.63|P-value:8.69E-5 ID:SGTC_2437|Compound:5741531|FD-Score:5.96|P-value:6.56E-7 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.94|P-value:7.22E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.23|P-value:3.03E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:6.74|P-value:2.13E-8 ID:SGTC_2523|Compound:spermine|FD-Score:4.26|P-value:2.76E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:6.02|P-value:5.06E-7 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.92|P-value:7.50E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:5.01|P-value:2.44E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:5.76|P-value:1.48E-6 ID:SGTC_2620|Compound:irigenin|FD-Score:4.35|P-value:2.13E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:6.07|P-value:4.03E-7 ID:SGTC_2650|Compound:prasterone|FD-Score:6.11|P-value:3.51E-7 ID:SGTC_2669|Compound:eugenol|FD-Score:6.35|P-value:1.24E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:11.90|P-value:1.29E-22 ID:SGTC_2752|Compound:diclazuril|FD-Score:8.45|P-value:3.06E-12 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:15.30|P-value:5.31E-36 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.83|P-value:7.73E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.98|P-value:6.33E-4 ID:SGTC_3257|Compound:9139206|FD-Score:4.80|P-value:4.89E-5 ID:SGTC_3284|Compound:9108171|FD-Score:4.14|P-value:4.01E-4 ID:SGTC_3308|Compound:9128332|FD-Score:9.25|P-value:2.45E-14 ID:SGTC_19|Compound:0279-0214|FD-Score:4.21|P-value:3.24E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:6.96|P-value:7.56E-9 ID:SGTC_25|Compound:0118-0223|FD-Score:-4.59|P-value:7.68E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:6.77|P-value:1.82E-8 ID:SGTC_51|Compound:1013-0126|FD-Score:4.07|P-value:4.88E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.83|P-value:9.73E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.44|P-value:1.62E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:4.54|P-value:1.19E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:4.12|P-value:4.23E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:4.64|P-value:8.44E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:5.12|P-value:1.63E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:4.25|P-value:2.90E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:5.99|P-value:5.74E-7 ID:SGTC_167|Compound:3672-0051|FD-Score:10.20|P-value:4.48E-17 ID:SGTC_176|Compound:1486-1328|FD-Score:9.07|P-value:7.46E-14 ID:SGTC_180|Compound:1486-1293|FD-Score:8.59|P-value:1.38E-12 ID:SGTC_194|Compound:1486-1323|FD-Score:5.94|P-value:7.07E-7 ID:SGTC_205|Compound:1486-1330|FD-Score:7.58|P-value:3.49E-10 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-4.30|P-value:1.91E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:4.02|P-value:5.70E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:14.70|P-value:3.05E-33 ID:SGTC_298|Compound:1391-0729|FD-Score:5.85|P-value:9.95E-7 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.88|P-value:8.54E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.36|P-value:2.06E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.83|P-value:9.66E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:6.05|P-value:4.52E-7 ID:SGTC_470|Compound:aa-861|FD-Score:4.23|P-value:3.07E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:5.32|P-value:8.02E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:4.98|P-value:2.66E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:5.32|P-value:7.97E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:-3.81|P-value:8.22E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.83|P-value:4.50E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:7.16|P-value:2.92E-9 ID:SGTC_585|Compound:0kpi-0023|FD-Score:8.00|P-value:3.72E-11 ID:SGTC_596|Compound:1155-0152|FD-Score:4.49|P-value:1.36E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:5.16|P-value:1.44E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.61|P-value:9.31E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:4.36|P-value:2.08E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:3.95|P-value:6.95E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.92|P-value:7.48E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:6.97|P-value:7.43E-9 ID:SGTC_792|Compound:4534-1957|FD-Score:6.52|P-value:5.71E-8 ID:SGTC_823|Compound:0417-1665|FD-Score:3.87|P-value:8.61E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:4.75|P-value:5.97E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:8.03|P-value:3.16E-11 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.79|P-value:8.61E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.93|P-value:3.23E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.95|P-value:7.00E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.08|P-value:4.78E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.19|P-value:3.42E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:6.77|P-value:1.85E-8 ID:SGTC_1219|Compound:1469-0211|FD-Score:4.42|P-value:1.68E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:6.53|P-value:5.47E-8 ID:SGTC_1245|Compound:0418-0076|FD-Score:6.20|P-value:2.40E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:5.78|P-value:1.34E-6 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.62|P-value:9.00E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.22|P-value:3.17E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:6.78|P-value:1.74E-8 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.50|P-value:6.46E-8 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.03|P-value:5.57E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:-3.82|P-value:7.89E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:6.39|P-value:1.04E-7 ID:SGTC_1427|Compound:4048-4900|FD-Score:6.97|P-value:7.24E-9 ID:SGTC_1455|Compound:4262-0120|FD-Score:4.80|P-value:4.99E-5 ID:SGTC_1482|Compound:3346-2049|FD-Score:5.01|P-value:2.40E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:4.45|P-value:1.53E-4 ID:SGTC_1516|Compound:st013856|FD-Score:-4.23|P-value:2.41E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.22|P-value:3.16E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:5.48|P-value:4.25E-6 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.13|P-value:1.60E-5 ID:SGTC_1636|Compound:st007707|FD-Score:3.93|P-value:7.34E-4 ID:SGTC_1649|Compound:st011737|FD-Score:4.83|P-value:4.43E-5 ID:SGTC_1655|Compound:st012546|FD-Score:4.57|P-value:1.07E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.62|P-value:8.88E-5 ID:SGTC_1697|Compound:st025554|FD-Score:4.99|P-value:2.62E-5 ID:SGTC_1715|Compound:st032160|FD-Score:4.25|P-value:2.90E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.87|P-value:8.75E-4 ID:SGTC_1757|Compound:st041620|FD-Score:5.83|P-value:1.12E-6 ID:SGTC_1824|Compound:st053723|FD-Score:4.71|P-value:6.74E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:5.10|P-value:1.75E-5 ID:SGTC_1881|Compound:5652484|FD-Score:5.61|P-value:2.65E-6 ID:SGTC_1882|Compound:5615643|FD-Score:3.85|P-value:9.23E-4 ID:SGTC_1921|Compound:5740136|FD-Score:5.26|P-value:9.70E-6 ID:SGTC_1933|Compound:st074711|FD-Score:6.70|P-value:2.58E-8 ID:SGTC_1937|Compound:st074714|FD-Score:8.20|P-value:1.28E-11 ID:SGTC_1952|Compound:st077036|FD-Score:6.67|P-value:2.93E-8 ID:SGTC_1975|Compound:st070967|FD-Score:3.83|P-value:9.79E-4 ID:SGTC_2175|Compound:5807670|FD-Score:5.47|P-value:4.56E-6 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:-4.18|P-value:2.79E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:7.39|P-value:9.02E-10 ID:SGTC_2340|Compound:7987427|FD-Score:4.04|P-value:5.37E-4 ID:SGTC_2384|Compound:9036245|FD-Score:4.61|P-value:9.29E-5 ID:SGTC_2403|Compound:6032726|FD-Score:7.27|P-value:1.72E-9 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.63|P-value:8.69E-5 ID:SGTC_2437|Compound:5741531|FD-Score:5.96|P-value:6.56E-7 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.94|P-value:7.22E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.23|P-value:3.03E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:6.74|P-value:2.13E-8 ID:SGTC_2523|Compound:spermine|FD-Score:4.26|P-value:2.76E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:6.02|P-value:5.06E-7 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.92|P-value:7.50E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:5.01|P-value:2.44E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:5.76|P-value:1.48E-6 ID:SGTC_2620|Compound:irigenin|FD-Score:4.35|P-value:2.13E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:6.07|P-value:4.03E-7 ID:SGTC_2650|Compound:prasterone|FD-Score:6.11|P-value:3.51E-7 ID:SGTC_2669|Compound:eugenol|FD-Score:6.35|P-value:1.24E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:11.90|P-value:1.29E-22 ID:SGTC_2752|Compound:diclazuril|FD-Score:8.45|P-value:3.06E-12 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:15.30|P-value:5.31E-36 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.83|P-value:7.73E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.98|P-value:6.33E-4 ID:SGTC_3257|Compound:9139206|FD-Score:4.80|P-value:4.89E-5 ID:SGTC_3284|Compound:9108171|FD-Score:4.14|P-value:4.01E-4 ID:SGTC_3308|Compound:9128332|FD-Score:9.25|P-value:2.45E-14

Top fitness defect scores for YGL117W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2758 dehydroepiandrosterone 15.30 69.3 µM 5.31E-36 8 4.44E-53
2 SGTC_285 1486-1325 14.70 46.0 µM 3.05E-33 1 5.96E-49
3 SGTC_2688 kanamycin b 11.90 96.7 µM 1.29E-22 calcium & mitochondrial duress 12 4.63E-33
4 SGTC_167 3672-0051 10.20 66.2 µM 4.48E-17 1 8.83E-25
5 SGTC_3308 9128332 9.25 17.6 µM 2.45E-14 plasma membrane duress 24 1.09E-20
6 SGTC_176 1486-1328 9.07 72.8 µM 7.46E-14 7 5.73E-20
7 SGTC_180 1486-1293 8.59 102.8 µM 1.38E-12 14 4.47E-18
8 SGTC_2752 diclazuril 8.45 33.1 µM 3.06E-12 30 1.47E-17
9 SGTC_1937 st074714 8.20 47.2 µM 1.28E-11 5 1.24E-16
10 SGTC_981 1488-1094 8.03 54.9 µM 3.16E-11 3 4.78E-16
11 SGTC_585 0kpi-0023 8.00 191.0 µM 3.72E-11 4 6.10E-16
12 SGTC_205 1486-1330 7.58 71.9 µM 3.49E-10 3 1.72E-14
13 SGTC_2232 chlorophetanol 7.39 41.5 µM 9.02E-10 TRP & mitochondrial translation 25 7.07E-14
14 SGTC_2403 6032726 7.27 181.2 µM 1.72E-9 6 1.86E-13
15 SGTC_583 1488-1091 7.16 88.9 µM 2.92E-9 3 4.07E-13
16 SGTC_1427 4048-4900 6.97 550.0 nM 7.24E-9 11 1.58E-12
17 SGTC_748 0136-0228 6.97 77.9 µM 7.43E-9 redox potentiating 29 1.64E-12
18 SGTC_24 0417-1663 6.96 219.0 µM 7.56E-9 4 1.68E-12
19 SGTC_1284 0929-0043 6.78 16.0 µM 1.74E-8 4 5.82E-12
20 SGTC_50 0929-0078 6.77 56.4 µM 1.82E-8 20 6.24E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.553 5.28E-268 YDR035W ARO3 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
0.551 6.42E-266 YEL009C GCN4 hom Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
0.515 6.07E-226 YDR007W TRP1 hom Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
0.510 2.15E-220 YDR008C_d YDR008C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.503 9.47E-214 YDR283C GCN2 hom Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
0.501 2.32E-212 YKR026C GCN3 hom Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
0.475 2.10E-187 YDR354W TRP4 hom Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
0.466 7.39E-180 YGL026C TRP5 hom Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
0.437 7.62E-156 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.428 5.24E-149 YFR009W GCN20 hom Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
0.389 1.91E-120 YER090W TRP2 hom Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
0.368 1.27E-107 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.222 1.22E-38 YGL148W ARO2 hom Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress
0.145 3.88E-17 YJL088W ARG3 hom Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
0.119 4.45E-12 YKL013C ARC19 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches