YGL118C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL118C / YGL118C

Click on Significant Values for Screen Details ID:SGTC_143|Compound:4032-1194|FD-Score:3.37|P-value:3.35E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:10.80|P-value:5.68E-28 ID:SGTC_145|Compound:3737-0113|FD-Score:15.10|P-value:2.58E-53 ID:SGTC_162|Compound:k030-0015|FD-Score:5.18|P-value:8.10E-8 ID:SGTC_170|Compound:4197-0004|FD-Score:3.67|P-value:1.04E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:5.07|P-value:1.47E-7 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.47|P-value:3.20E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:4.39|P-value:4.49E-6 ID:SGTC_264|Compound:promethazine|FD-Score:11.90|P-value:1.43E-33 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.07|P-value:9.24E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.08|P-value:9.39E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.45|P-value:2.48E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.09|P-value:9.09E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.19|P-value:6.47E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.97|P-value:2.99E-5 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.08|P-value:9.33E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.08|P-value:9.45E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.00|P-value:2.71E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.94|P-value:3.38E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.65|P-value:1.15E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:11.10|P-value:8.82E-30 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:4.39|P-value:4.59E-6 ID:SGTC_1519|Compound:esterone|FD-Score:6.71|P-value:5.70E-12 ID:SGTC_1529|Compound:apigenin|FD-Score:3.34|P-value:3.75E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:5.06|P-value:1.58E-7 ID:SGTC_1548|Compound:st061468|FD-Score:3.99|P-value:2.80E-5 ID:SGTC_1563|Compound:conessine|FD-Score:4.06|P-value:2.07E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:5.00|P-value:2.15E-7 ID:SGTC_1569|Compound:carminic acid|FD-Score:4.01|P-value:2.55E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:5.33|P-value:3.53E-8 ID:SGTC_1730|Compound:st033808|FD-Score:-4.99|P-value:2.05E-7 ID:SGTC_1734|Compound:st037168|FD-Score:3.25|P-value:5.17E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.97|P-value:2.78E-5 ID:SGTC_1809|Compound:st050081|FD-Score:3.09|P-value:8.96E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.37|P-value:3.35E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.91|P-value:1.41E-12 ID:SGTC_2032|Compound:5185112|FD-Score:-3.08|P-value:8.82E-4 ID:SGTC_2118|Compound:5526350|FD-Score:4.38|P-value:4.89E-6 ID:SGTC_2338|Compound:7999974|FD-Score:3.41|P-value:2.90E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.47|P-value:2.28E-4 ID:SGTC_2344|Compound:7990960|FD-Score:5.06|P-value:1.58E-7 ID:SGTC_2348|Compound:9022543|FD-Score:-4.59|P-value:1.60E-6 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.98|P-value:2.93E-5 ID:SGTC_2888|Compound:9058547|FD-Score:-3.14|P-value:7.17E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.28|P-value:4.58E-4 ID:SGTC_3040|Compound:9091894|FD-Score:6.29|P-value:1.03E-10 ID:SGTC_3248|Compound:9135562|FD-Score:-3.53|P-value:1.71E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.40|P-value:2.98E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.34|P-value:3.71E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.69|P-value:9.79E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.37|P-value:3.35E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:10.80|P-value:5.68E-28 ID:SGTC_145|Compound:3737-0113|FD-Score:15.10|P-value:2.58E-53 ID:SGTC_162|Compound:k030-0015|FD-Score:5.18|P-value:8.10E-8 ID:SGTC_170|Compound:4197-0004|FD-Score:3.67|P-value:1.04E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:5.07|P-value:1.47E-7 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.47|P-value:3.20E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:4.39|P-value:4.49E-6 ID:SGTC_264|Compound:promethazine|FD-Score:11.90|P-value:1.43E-33 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.07|P-value:9.24E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.08|P-value:9.39E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.45|P-value:2.48E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.09|P-value:9.09E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.19|P-value:6.47E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.97|P-value:2.99E-5 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.08|P-value:9.33E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.08|P-value:9.45E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.00|P-value:2.71E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.94|P-value:3.38E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.65|P-value:1.15E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:11.10|P-value:8.82E-30 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:4.39|P-value:4.59E-6 ID:SGTC_1519|Compound:esterone|FD-Score:6.71|P-value:5.70E-12 ID:SGTC_1529|Compound:apigenin|FD-Score:3.34|P-value:3.75E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:5.06|P-value:1.58E-7 ID:SGTC_1548|Compound:st061468|FD-Score:3.99|P-value:2.80E-5 ID:SGTC_1563|Compound:conessine|FD-Score:4.06|P-value:2.07E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:5.00|P-value:2.15E-7 ID:SGTC_1569|Compound:carminic acid|FD-Score:4.01|P-value:2.55E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:5.33|P-value:3.53E-8 ID:SGTC_1730|Compound:st033808|FD-Score:-4.99|P-value:2.05E-7 ID:SGTC_1734|Compound:st037168|FD-Score:3.25|P-value:5.17E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.97|P-value:2.78E-5 ID:SGTC_1809|Compound:st050081|FD-Score:3.09|P-value:8.96E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.37|P-value:3.35E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.91|P-value:1.41E-12 ID:SGTC_2032|Compound:5185112|FD-Score:-3.08|P-value:8.82E-4 ID:SGTC_2118|Compound:5526350|FD-Score:4.38|P-value:4.89E-6 ID:SGTC_2338|Compound:7999974|FD-Score:3.41|P-value:2.90E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.47|P-value:2.28E-4 ID:SGTC_2344|Compound:7990960|FD-Score:5.06|P-value:1.58E-7 ID:SGTC_2348|Compound:9022543|FD-Score:-4.59|P-value:1.60E-6 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.98|P-value:2.93E-5 ID:SGTC_2888|Compound:9058547|FD-Score:-3.14|P-value:7.17E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.28|P-value:4.58E-4 ID:SGTC_3040|Compound:9091894|FD-Score:6.29|P-value:1.03E-10 ID:SGTC_3248|Compound:9135562|FD-Score:-3.53|P-value:1.71E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.40|P-value:2.98E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.34|P-value:3.71E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.69|P-value:9.79E-5

Top fitness defect scores for YGL118C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_145 3737-0113 15.10 38.4 µM 2.58E-53 DNA intercalators 2 4.15E-52
2 SGTC_264 promethazine 11.90 12.5 mM 1.43E-33 DNA intercalators 8 7.77E-33
3 SGTC_1515 3460-0031 11.10 42.1 µM 8.82E-30 DNA intercalators 1 3.89E-29
4 SGTC_144 4161-2749 10.80 112.4 µM 5.68E-28 DNA intercalators 1 2.27E-27
5 SGTC_1926 methyl fluorone black 6.91 53.6 µM 1.41E-12 DNA intercalators 14 2.45E-12
6 SGTC_1519 esterone 6.71 74.0 µM 5.70E-12 DNA intercalators 2 9.62E-12
7 SGTC_3040 9091894 6.29 49.5 µM 1.03E-10 DNA intercalators 7 1.63E-10
8 SGTC_1572 epiandrosterone 5.33 68.9 µM 3.53E-8 15 4.88E-8
9 SGTC_162 k030-0015 5.18 37.8 µM 8.10E-8 iron homeostasis 9 1.10E-7
10 SGTC_171 k064-0041 5.07 9.7 µM 1.47E-7 heme requiring 14 1.97E-7
11 SGTC_2344 7990960 5.06 77.0 µM 1.58E-7 13 2.11E-7
12 SGTC_1546 5-methoxyflavanone 5.06 78.7 µM 1.58E-7 6 2.11E-7
13 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 5.00 85.4 µM 2.15E-7 7 2.86E-7
14 SGTC_219 mitoxanthrone 4.47 164.4 µM 3.20E-6 DNA intercalators 40 4.00E-6
15 SGTC_257 daunorubicin 4.39 18.5 µM 4.49E-6 anthracycline transcription coupled DNA repair 18 5.58E-6
16 SGTC_1517 deoxycholic acid methyl ester 4.39 49.2 µM 4.59E-6 5 5.70E-6
17 SGTC_2118 5526350 4.38 200.0 µM 4.89E-6 8 6.06E-6
18 SGTC_1563 conessine 4.06 56.1 µM 2.07E-5 12 2.49E-5
19 SGTC_1569 carminic acid 4.01 40.6 µM 2.55E-5 14 3.05E-5
20 SGTC_1468 k284-1086 4.00 134.0 µM 2.71E-5 DNA intercalators 35 3.23E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.579 1.81E-299 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.529 1.79E-241 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.525 8.85E-237 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.500 3.29E-211 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.433 4.41E-153 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.407 6.06E-134 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.403 6.77E-131 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.396 2.57E-126 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.387 2.58E-120 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.361 4.73E-104 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.359 1.27E-102 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.342 1.22E-92 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.333 1.04E-87 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.317 5.88E-79 YNL101W AVT4 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.304 1.37E-72 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles