YGL121C / GPG1

Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL121C / GPG1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.23|P-value:1.47E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:3.23|P-value:1.77E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.34|P-value:1.10E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:-2.86|P-value:8.86E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.40|P-value:8.44E-5 ID:SGTC_271|Compound:rotenone|FD-Score:3.19|P-value:2.12E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-2.88|P-value:8.27E-4 ID:SGTC_482|Compound:fipronil|FD-Score:-2.90|P-value:7.69E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.66|P-value:3.13E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:5.67|P-value:2.06E-10 ID:SGTC_520|Compound:3584-0023|FD-Score:-5.61|P-value:3.91E-10 ID:SGTC_522|Compound:1273-0010|FD-Score:4.38|P-value:6.48E-7 ID:SGTC_542|Compound:3381-0244|FD-Score:3.33|P-value:1.14E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.39|P-value:8.77E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:3.44|P-value:7.10E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:3.27|P-value:1.50E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.17|P-value:2.29E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.20|P-value:2.01E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:2.90|P-value:6.75E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.34|P-value:1.09E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-3.32|P-value:1.42E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:-2.85|P-value:9.29E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:4.82|P-value:5.18E-8 ID:SGTC_863|Compound:0466-0191|FD-Score:4.46|P-value:4.34E-7 ID:SGTC_884|Compound:0851-0618|FD-Score:3.82|P-value:1.23E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.41|P-value:8.23E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.64|P-value:3.34E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:2.99|P-value:4.64E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.06|P-value:4.07E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:2.91|P-value:6.48E-4 ID:SGTC_1660|Compound:st012960|FD-Score:2.96|P-value:5.27E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.58|P-value:4.55E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-3.20|P-value:2.33E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-3.83|P-value:1.40E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-3.08|P-value:3.87E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.52|P-value:4.92E-5 ID:SGTC_2148|Compound:5546263|FD-Score:2.82|P-value:8.95E-4 ID:SGTC_2184|Compound:6075246|FD-Score:2.89|P-value:6.81E-4 ID:SGTC_2269|Compound:7935389|FD-Score:4.37|P-value:7.12E-7 ID:SGTC_2287|Compound:7945887|FD-Score:-3.19|P-value:2.45E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.75|P-value:1.68E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-2.93|P-value:6.81E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.08|P-value:3.33E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-3.67|P-value:3.00E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-3.29|P-value:1.60E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:4.23|P-value:1.47E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:3.23|P-value:1.77E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.34|P-value:1.10E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:-2.86|P-value:8.86E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.40|P-value:8.44E-5 ID:SGTC_271|Compound:rotenone|FD-Score:3.19|P-value:2.12E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-2.88|P-value:8.27E-4 ID:SGTC_482|Compound:fipronil|FD-Score:-2.90|P-value:7.69E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.66|P-value:3.13E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:5.67|P-value:2.06E-10 ID:SGTC_520|Compound:3584-0023|FD-Score:-5.61|P-value:3.91E-10 ID:SGTC_522|Compound:1273-0010|FD-Score:4.38|P-value:6.48E-7 ID:SGTC_542|Compound:3381-0244|FD-Score:3.33|P-value:1.14E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.39|P-value:8.77E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:3.44|P-value:7.10E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:3.27|P-value:1.50E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.17|P-value:2.29E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.20|P-value:2.01E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:2.90|P-value:6.75E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.34|P-value:1.09E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-3.32|P-value:1.42E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:-2.85|P-value:9.29E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:4.82|P-value:5.18E-8 ID:SGTC_863|Compound:0466-0191|FD-Score:4.46|P-value:4.34E-7 ID:SGTC_884|Compound:0851-0618|FD-Score:3.82|P-value:1.23E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.41|P-value:8.23E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.64|P-value:3.34E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:2.99|P-value:4.64E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.06|P-value:4.07E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:2.91|P-value:6.48E-4 ID:SGTC_1660|Compound:st012960|FD-Score:2.96|P-value:5.27E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.58|P-value:4.55E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-3.20|P-value:2.33E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-3.83|P-value:1.40E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-3.08|P-value:3.87E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.52|P-value:4.92E-5 ID:SGTC_2148|Compound:5546263|FD-Score:2.82|P-value:8.95E-4 ID:SGTC_2184|Compound:6075246|FD-Score:2.89|P-value:6.81E-4 ID:SGTC_2269|Compound:7935389|FD-Score:4.37|P-value:7.12E-7 ID:SGTC_2287|Compound:7945887|FD-Score:-3.19|P-value:2.45E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.75|P-value:1.68E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-2.93|P-value:6.81E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.08|P-value:3.33E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-3.67|P-value:3.00E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-3.29|P-value:1.60E-4

Top fitness defect scores for YGL121C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_517 1365-0151 5.67 113.0 µM 2.06E-10 13 7.35E-9
2 SGTC_859 0439-0102 4.82 54.6 µM 5.18E-8 redox potentiating 10 7.18E-7
3 SGTC_863 0466-0191 4.46 129.0 µM 4.34E-7 cell wall 57 4.18E-6
4 SGTC_522 1273-0010 4.38 11.6 µM 6.48E-7 60S ribosome export 16 5.83E-6
5 SGTC_2269 7935389 4.37 174.4 µM 7.12E-7 tubulin folding & SWR complex 20 6.31E-6
6 SGTC_8 0354-0001 4.23 70.0 µM 1.47E-6 67 1.15E-5
7 SGTC_884 0851-0618 3.82 334.0 µM 1.23E-5 17 6.74E-5
8 SGTC_2567 aureobasidin a 3.75 60.0 nM 1.68E-5 102 8.70E-5
9 SGTC_1916 st067606 3.52 49.2 µM 4.92E-5 56 2.13E-4
10 SGTC_683 panaxydol 3.44 45.0 µM 7.10E-5 sphingolipid biosynthesis & PDR1 51 2.89E-4
11 SGTC_1012 4112-3522 3.41 18.0 µM 8.23E-5 38 3.27E-4
12 SGTC_266 formosanin C 3.40 406.0 nM 8.44E-5 sphingolipid biosynthesis & PDR1 85 3.34E-4
13 SGTC_639 0833-0042 3.39 114.0 µM 8.77E-5 69 3.45E-4
14 SGTC_844 0330-0132 3.34 15.3 µM 1.09E-4 29 4.12E-4
15 SGTC_142 0335-0849 3.34 62.7 µM 1.10E-4 ubiquinone biosynthesis & proteasome 173 4.15E-4
16 SGTC_542 3381-0244 3.33 89.3 µM 1.14E-4 67 4.29E-4
17 SGTC_727 3032-0951 3.27 202.0 µM 1.50E-4 48 5.39E-4
18 SGTC_58 0957-0393 3.23 9.0 µM 1.77E-4 cell wall 462 6.18E-4
19 SGTC_801 0866-0028 3.20 10.1 µM 2.01E-4 73 6.86E-4
20 SGTC_271 rotenone 3.19 740.0 µM 2.12E-4 59 7.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 7.63E-21 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.156 9.56E-20 YOR311C DGK1 hom Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain
0.147 8.78E-18 YDR208W MSS4 het Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
0.145 3.66E-17 YNL289W PCL1 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth
0.144 4.26E-17 YBR244W GPX2 hom Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress
0.137 1.65E-15 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.134 6.60E-15 YDL189W RBS1 hom Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
0.124 4.48E-13 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.119 4.53E-12 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.113 5.89E-11 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.112 8.81E-11 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.112 9.22E-11 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.110 1.48E-10 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.109 2.89E-10 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.107 4.55E-10 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C