YGL130W / CEG1

Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL130W / CEG1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:-3.97|P-value:4.10E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:3.30|P-value:1.03E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:2.86|P-value:6.46E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.31|P-value:9.70E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.31|P-value:1.01E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.68|P-value:6.71E-8 ID:SGTC_536|Compound:3852-0578|FD-Score:2.77|P-value:8.97E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:2.98|P-value:3.97E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.40|P-value:6.32E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:-2.86|P-value:6.61E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-2.77|P-value:9.27E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-2.78|P-value:8.92E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.55|P-value:3.17E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.20|P-value:1.53E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:2.83|P-value:7.03E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:2.90|P-value:5.45E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.85|P-value:7.43E-6 ID:SGTC_1531|Compound:st059297|FD-Score:3.78|P-value:1.01E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.19|P-value:1.61E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:2.80|P-value:8.00E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.85|P-value:7.69E-6 ID:SGTC_1559|Compound:coumarin 343|FD-Score:-2.85|P-value:6.85E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:2.75|P-value:9.76E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.90|P-value:5.74E-6 ID:SGTC_1715|Compound:st032160|FD-Score:-2.82|P-value:7.66E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-6.40|P-value:3.10E-13 ID:SGTC_1736|Compound:st036774|FD-Score:2.87|P-value:6.24E-4 ID:SGTC_1737|Compound:st035557|FD-Score:7.84|P-value:5.23E-19 ID:SGTC_1738|Compound:st035555|FD-Score:4.09|P-value:2.01E-6 ID:SGTC_1742|Compound:st038235|FD-Score:4.00|P-value:3.41E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:2.92|P-value:5.03E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.61|P-value:2.38E-5 ID:SGTC_1984|Compound:st072354|FD-Score:3.36|P-value:7.66E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.81|P-value:8.92E-6 ID:SGTC_2095|Compound:5432005|FD-Score:2.80|P-value:7.89E-4 ID:SGTC_2103|Compound:5378138|FD-Score:4.66|P-value:7.74E-8 ID:SGTC_2329|Compound:6138490|FD-Score:3.40|P-value:6.28E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.36|P-value:7.68E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-4.21|P-value:1.08E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.09|P-value:2.60E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.39|P-value:3.78E-7 ID:SGTC_2469|Compound:5655019|FD-Score:2.98|P-value:3.97E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.52|P-value:3.69E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.25|P-value:1.25E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:2.97|P-value:4.09E-4 ID:SGTC_2798|Compound:7813637|FD-Score:5.04|P-value:6.77E-9 ID:SGTC_3009|Compound:9080819|FD-Score:2.79|P-value:8.37E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.00|P-value:3.69E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.97|P-value:4.10E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:3.30|P-value:1.03E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:2.86|P-value:6.46E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.31|P-value:9.70E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.31|P-value:1.01E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.68|P-value:6.71E-8 ID:SGTC_536|Compound:3852-0578|FD-Score:2.77|P-value:8.97E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:2.98|P-value:3.97E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.40|P-value:6.32E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:-2.86|P-value:6.61E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-2.77|P-value:9.27E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-2.78|P-value:8.92E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.55|P-value:3.17E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.20|P-value:1.53E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:2.83|P-value:7.03E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:2.90|P-value:5.45E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.85|P-value:7.43E-6 ID:SGTC_1531|Compound:st059297|FD-Score:3.78|P-value:1.01E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.19|P-value:1.61E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:2.80|P-value:8.00E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.85|P-value:7.69E-6 ID:SGTC_1559|Compound:coumarin 343|FD-Score:-2.85|P-value:6.85E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:2.75|P-value:9.76E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.90|P-value:5.74E-6 ID:SGTC_1715|Compound:st032160|FD-Score:-2.82|P-value:7.66E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-6.40|P-value:3.10E-13 ID:SGTC_1736|Compound:st036774|FD-Score:2.87|P-value:6.24E-4 ID:SGTC_1737|Compound:st035557|FD-Score:7.84|P-value:5.23E-19 ID:SGTC_1738|Compound:st035555|FD-Score:4.09|P-value:2.01E-6 ID:SGTC_1742|Compound:st038235|FD-Score:4.00|P-value:3.41E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:2.92|P-value:5.03E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.61|P-value:2.38E-5 ID:SGTC_1984|Compound:st072354|FD-Score:3.36|P-value:7.66E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.81|P-value:8.92E-6 ID:SGTC_2095|Compound:5432005|FD-Score:2.80|P-value:7.89E-4 ID:SGTC_2103|Compound:5378138|FD-Score:4.66|P-value:7.74E-8 ID:SGTC_2329|Compound:6138490|FD-Score:3.40|P-value:6.28E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.36|P-value:7.68E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-4.21|P-value:1.08E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.09|P-value:2.60E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.39|P-value:3.78E-7 ID:SGTC_2469|Compound:5655019|FD-Score:2.98|P-value:3.97E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.52|P-value:3.69E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.25|P-value:1.25E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:2.97|P-value:4.09E-4 ID:SGTC_2798|Compound:7813637|FD-Score:5.04|P-value:6.77E-9 ID:SGTC_3009|Compound:9080819|FD-Score:2.79|P-value:8.37E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.00|P-value:3.69E-4

Top fitness defect scores for YGL130W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1737 st035557 7.84 69.7 µM 5.23E-19 1 2.19E-15 3.23
2 SGTC_2798 7813637 5.04 45.5 µM 6.77E-9 6 2.28E-7 0.05
3 SGTC_459 nigericin 4.68 15.3 µM 6.71E-8 7 1.42E-6 0.09
4 SGTC_2103 5378138 4.66 10.0 µM 7.74E-8 1 1.59E-6 0.92
5 SGTC_2429 5902844 4.39 64.4 µM 3.78E-7 6 5.60E-6 0.43
6 SGTC_1738 st035555 4.09 74.0 µM 2.01E-6 TSC3-RPN4 3 2.12E-5 0.14
7 SGTC_1742 st038235 4.00 28.9 µM 3.41E-6 mitochondrial stress 8 3.23E-5 0.00
8 SGTC_2093 5331342 3.81 194.4 µM 8.92E-6 7 6.96E-5 0.31
9 SGTC_1531 st059297 3.78 52.4 µM 1.01E-5 5 7.69E-5 0.33
10 SGTC_1945 st075991 3.61 56.6 µM 2.38E-5 60S ribosome export 15 1.53E-4 0.11
11 SGTC_1059 3448-6867 3.55 171.0 µM 3.17E-5 8 1.92E-4 0.14
12 SGTC_2580 diallyl disulphide 3.52 81.4 µM 3.69E-5 11 2.16E-4 0.04
13 SGTC_2329 6138490 3.40 200.0 µM 6.28E-5 19 3.31E-4 0.08
14 SGTC_751 0833-0568 3.40 350.0 µM 6.32E-5 4 3.33E-4 0.09
15 SGTC_1984 st072354 3.36 53.1 µM 7.66E-5 3 3.88E-4 0.05
16 SGTC_2344 7990960 3.36 77.0 µM 7.68E-5 50 3.89E-4 0.03
17 SGTC_174 3553-0389 3.31 74.3 µM 9.70E-5 8 4.69E-4 0.04
18 SGTC_100 0086-0128 3.30 49.6 µM 1.03E-4 copper-dependent oxidative stress 15 4.90E-4 0.06
19 SGTC_2583 asiatic acid 3.25 100.0 µM 1.25E-4 17 5.76E-4 0.03
20 SGTC_1205 4161-2785 3.20 76.0 µM 1.53E-4 8 6.76E-4 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 9.32E-19 YOL122C SMF1 hom Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.134 5.95E-15 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.123 8.74E-13 YGL157W ARI1 hom NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily
0.123 9.96E-13 YOR298W MUM3 hom Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases
0.115 2.33E-11 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.115 2.94E-11 YDL164C CDC9 het DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
0.106 6.80E-10 YLL025W PAU17 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene
0.101 4.62E-9 YBR235W VHC1 hom Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family
0.094 5.73E-8 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.091 1.24E-7 YHL017W_p YHL017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication
0.091 1.28E-7 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.091 1.42E-7 YOR321W PMT3 hom Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication
0.087 4.52E-7 YNL096C RPS7B hom Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.087 4.61E-7 YOL075C_p YOL075C_p hom Putative ABC transporter
0.086 5.85E-7 YJR062C NTA1 hom Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation