YGL134W / PCL10

Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL134W / PCL10

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-2.90|P-value:3.94E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-4.85|P-value:1.02E-8 ID:SGTC_57|Compound:miconazole|FD-Score:5.01|P-value:3.92E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:6.31|P-value:1.74E-13 ID:SGTC_59|Compound:0330-0160|FD-Score:-4.10|P-value:1.09E-6 ID:SGTC_60|Compound:0986-0278|FD-Score:-5.43|P-value:1.75E-10 ID:SGTC_63|Compound:0099-0242|FD-Score:4.42|P-value:1.72E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.11|P-value:1.59E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-2.72|P-value:8.25E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-4.16|P-value:7.33E-7 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.65|P-value:1.18E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.00|P-value:1.86E-6 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.13|P-value:1.45E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.43|P-value:3.63E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.68|P-value:1.06E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.64|P-value:1.40E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:2.80|P-value:6.37E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.98|P-value:2.11E-6 ID:SGTC_798|Compound:1287-0182|FD-Score:3.61|P-value:1.61E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:3.29|P-value:7.77E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.42|P-value:3.79E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:-2.80|P-value:6.02E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.70|P-value:9.57E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.11|P-value:1.70E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.23|P-value:9.31E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.58|P-value:1.88E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.21|P-value:1.07E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-4.20|P-value:5.90E-7 ID:SGTC_1851|Compound:st056236|FD-Score:3.20|P-value:1.16E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.58|P-value:1.90E-5 ID:SGTC_2107|Compound:5363541|FD-Score:2.70|P-value:9.63E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-4.27|P-value:4.00E-7 ID:SGTC_2316|Compound:5844804|FD-Score:3.17|P-value:1.32E-4 ID:SGTC_2341|Compound:7987486|FD-Score:2.80|P-value:6.35E-4 ID:SGTC_2347|Compound:9049783|FD-Score:5.86|P-value:7.41E-12 ID:SGTC_2372|Compound:9071633|FD-Score:2.75|P-value:7.72E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.19|P-value:1.23E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-3.00|P-value:2.54E-4 ID:SGTC_2386|Compound:9075165|FD-Score:2.95|P-value:3.38E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.93|P-value:3.68E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.49|P-value:1.17E-7 ID:SGTC_2876|Compound:9059903|FD-Score:2.71|P-value:9.08E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-2.88|P-value:4.23E-4 ID:SGTC_3297|Compound:9117502|FD-Score:2.73|P-value:8.28E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-2.74|P-value:7.56E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-2.90|P-value:3.94E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-4.85|P-value:1.02E-8 ID:SGTC_57|Compound:miconazole|FD-Score:5.01|P-value:3.92E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:6.31|P-value:1.74E-13 ID:SGTC_59|Compound:0330-0160|FD-Score:-4.10|P-value:1.09E-6 ID:SGTC_60|Compound:0986-0278|FD-Score:-5.43|P-value:1.75E-10 ID:SGTC_63|Compound:0099-0242|FD-Score:4.42|P-value:1.72E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.11|P-value:1.59E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-2.72|P-value:8.25E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-4.16|P-value:7.33E-7 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.65|P-value:1.18E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.00|P-value:1.86E-6 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.13|P-value:1.45E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.43|P-value:3.63E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.68|P-value:1.06E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.64|P-value:1.40E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:2.80|P-value:6.37E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.98|P-value:2.11E-6 ID:SGTC_798|Compound:1287-0182|FD-Score:3.61|P-value:1.61E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:3.29|P-value:7.77E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.42|P-value:3.79E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:-2.80|P-value:6.02E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.70|P-value:9.57E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.11|P-value:1.70E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.23|P-value:9.31E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.58|P-value:1.88E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.21|P-value:1.07E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-4.20|P-value:5.90E-7 ID:SGTC_1851|Compound:st056236|FD-Score:3.20|P-value:1.16E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.58|P-value:1.90E-5 ID:SGTC_2107|Compound:5363541|FD-Score:2.70|P-value:9.63E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-4.27|P-value:4.00E-7 ID:SGTC_2316|Compound:5844804|FD-Score:3.17|P-value:1.32E-4 ID:SGTC_2341|Compound:7987486|FD-Score:2.80|P-value:6.35E-4 ID:SGTC_2347|Compound:9049783|FD-Score:5.86|P-value:7.41E-12 ID:SGTC_2372|Compound:9071633|FD-Score:2.75|P-value:7.72E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.19|P-value:1.23E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-3.00|P-value:2.54E-4 ID:SGTC_2386|Compound:9075165|FD-Score:2.95|P-value:3.38E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.93|P-value:3.68E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.49|P-value:1.17E-7 ID:SGTC_2876|Compound:9059903|FD-Score:2.71|P-value:9.08E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-2.88|P-value:4.23E-4 ID:SGTC_3297|Compound:9117502|FD-Score:2.73|P-value:8.28E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-2.74|P-value:7.56E-4

Top fitness defect scores for YGL134W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 6.31 9.0 µM 1.74E-13 cell wall 194 1.39E-10
2 SGTC_2347 9049783 5.86 174.8 µM 7.41E-12 9 2.37E-9
3 SGTC_57 miconazole 5.01 162.5 nM 3.92E-9 ergosterol depletion effects on membrane 17 2.74E-7
4 SGTC_2693 st077581 4.49 40.7 µM 1.17E-7 21 3.61E-6
5 SGTC_63 0099-0242 4.42 26.7 µM 1.72E-7 mitochondrial stress 73 4.84E-6
6 SGTC_632 0781-2353 3.64 4.7 µM 1.40E-5 Golgi 56 1.38E-4
7 SGTC_798 1287-0182 3.61 476.0 µM 1.61E-5 30 1.53E-4
8 SGTC_1346 1488-2224 3.58 62.4 µM 1.88E-5 24 1.72E-4
9 SGTC_2013 4024628 3.58 200.0 µM 1.90E-5 60 1.74E-4
10 SGTC_865 0488-0499 3.29 301.0 µM 7.77E-5 37 5.10E-4
11 SGTC_1635 st007035 3.21 42.4 µM 1.07E-4 272 6.53E-4
12 SGTC_1851 st056236 3.20 18.9 µM 1.16E-4 40 6.92E-4
13 SGTC_2375 9072683 3.19 200.0 µM 1.23E-4 mitochondrial processes 45 7.24E-4
14 SGTC_2316 5844804 3.17 197.4 µM 1.32E-4 79 7.66E-4
15 SGTC_1121 fusaric acid 3.11 630.5 nM 1.70E-4 71 9.27E-4
16 SGTC_2386 9075165 2.95 157.4 µM 3.38E-4 34 0.00158
17 SGTC_2692 st077426 2.93 47.7 µM 3.68E-4 73 0.00168
18 SGTC_2341 7987486 2.80 176.7 µM 6.35E-4 81 0.00255
19 SGTC_716 1683-5115 2.80 658.0 µM 6.37E-4 87 0.00256
20 SGTC_2372 9071633 2.75 200.0 µM 7.72E-4 63 0.00297

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.301 2.60E-71 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.281 7.83E-62 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.237 2.88E-44 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.220 3.92E-38 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.220 6.92E-38 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.216 6.87E-37 YPL121C MEI5 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p
0.209 2.24E-34 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.206 2.07E-33 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.195 4.29E-30 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.195 4.71E-30 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.185 2.50E-27 YGR032W GSC2 hom Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
0.183 1.01E-26 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.182 2.40E-26 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.181 4.31E-26 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.180 6.19E-26 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress