YGL142C / GPI10

Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL142C / GPI10

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:2.93|P-value:7.11E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:2.85|P-value:9.68E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.26|P-value:1.98E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.25|P-value:2.34E-6 ID:SGTC_602|Compound:3130-1533|FD-Score:2.87|P-value:8.97E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.05|P-value:4.63E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.20|P-value:2.89E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:4.59|P-value:3.19E-7 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.61|P-value:4.44E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.88|P-value:1.25E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:-2.97|P-value:6.84E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:-6.23|P-value:8.56E-12 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:5.94|P-value:5.68E-11 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.11|P-value:4.67E-6 ID:SGTC_1175|Compound:0741-0056|FD-Score:-2.99|P-value:6.51E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-2.96|P-value:7.16E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.01|P-value:5.25E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:2.85|P-value:9.60E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.37|P-value:1.22E-4 ID:SGTC_1653|Compound:st012112|FD-Score:2.86|P-value:9.46E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.78|P-value:2.06E-5 ID:SGTC_1816|Compound:st051957|FD-Score:3.38|P-value:1.18E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.61|P-value:4.40E-5 ID:SGTC_1962|Compound:st076595|FD-Score:3.30|P-value:1.69E-4 ID:SGTC_2180|Compound:6301957|FD-Score:2.84|P-value:9.89E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.13|P-value:3.39E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.77|P-value:2.47E-5 ID:SGTC_2270|Compound:7924575|FD-Score:-4.00|P-value:8.11E-6 ID:SGTC_2402|Compound:5553605|FD-Score:-2.99|P-value:6.43E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-2.91|P-value:8.56E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-2.95|P-value:7.55E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.55|P-value:5.68E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.72|P-value:3.08E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.35|P-value:1.16E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:2.94|P-value:7.03E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.79|P-value:1.91E-5 ID:SGTC_2714|Compound:st079313|FD-Score:3.54|P-value:6.03E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.40|P-value:1.24E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-4.33|P-value:1.55E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.06|P-value:4.38E-4 ID:SGTC_2796|Compound:7949634|FD-Score:6.07|P-value:2.36E-11 ID:SGTC_2837|Compound:9008476|FD-Score:2.97|P-value:6.08E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-7.42|P-value:5.87E-16 ID:SGTC_3132|Compound:9126706|FD-Score:3.48|P-value:7.71E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-4.10|P-value:5.04E-6 ID:SGTC_3205|Compound:9113483|FD-Score:-4.31|P-value:1.71E-6 ID:SGTC_3288|Compound:9119690|FD-Score:3.65|P-value:3.67E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-3.00|P-value:6.28E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:2.93|P-value:7.11E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:2.85|P-value:9.68E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.26|P-value:1.98E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.25|P-value:2.34E-6 ID:SGTC_602|Compound:3130-1533|FD-Score:2.87|P-value:8.97E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.05|P-value:4.63E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.20|P-value:2.89E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:4.59|P-value:3.19E-7 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.61|P-value:4.44E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.88|P-value:1.25E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:-2.97|P-value:6.84E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:-6.23|P-value:8.56E-12 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:5.94|P-value:5.68E-11 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.11|P-value:4.67E-6 ID:SGTC_1175|Compound:0741-0056|FD-Score:-2.99|P-value:6.51E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-2.96|P-value:7.16E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.01|P-value:5.25E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:2.85|P-value:9.60E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.37|P-value:1.22E-4 ID:SGTC_1653|Compound:st012112|FD-Score:2.86|P-value:9.46E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.78|P-value:2.06E-5 ID:SGTC_1816|Compound:st051957|FD-Score:3.38|P-value:1.18E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.61|P-value:4.40E-5 ID:SGTC_1962|Compound:st076595|FD-Score:3.30|P-value:1.69E-4 ID:SGTC_2180|Compound:6301957|FD-Score:2.84|P-value:9.89E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.13|P-value:3.39E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.77|P-value:2.47E-5 ID:SGTC_2270|Compound:7924575|FD-Score:-4.00|P-value:8.11E-6 ID:SGTC_2402|Compound:5553605|FD-Score:-2.99|P-value:6.43E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-2.91|P-value:8.56E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-2.95|P-value:7.55E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.55|P-value:5.68E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.72|P-value:3.08E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.35|P-value:1.16E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:2.94|P-value:7.03E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.79|P-value:1.91E-5 ID:SGTC_2714|Compound:st079313|FD-Score:3.54|P-value:6.03E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.40|P-value:1.24E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-4.33|P-value:1.55E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.06|P-value:4.38E-4 ID:SGTC_2796|Compound:7949634|FD-Score:6.07|P-value:2.36E-11 ID:SGTC_2837|Compound:9008476|FD-Score:2.97|P-value:6.08E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-7.42|P-value:5.87E-16 ID:SGTC_3132|Compound:9126706|FD-Score:3.48|P-value:7.71E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-4.10|P-value:5.04E-6 ID:SGTC_3205|Compound:9113483|FD-Score:-4.31|P-value:1.71E-6 ID:SGTC_3288|Compound:9119690|FD-Score:3.65|P-value:3.67E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-3.00|P-value:6.28E-4

Top fitness defect scores for YGL142C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2796 7949634 6.07 45.5 µM 2.36E-11 2 6.56E-10 0.99
2 SGTC_1106 tegaserod maleate 5.94 11.7 µM 5.68E-11 2 1.39E-9 1.14
3 SGTC_808 0711-0032 4.59 135.0 µM 3.19E-7 4 2.25E-6 0.14
4 SGTC_2575 plumbagin 4.35 510.0 nM 1.16E-6 superoxide 25 6.82E-6 0.41
5 SGTC_1094 duloxetine 3.88 25.4 µM 1.25E-5 RPP1 & pyrimidine depletion 5 5.20E-5 0.20
6 SGTC_2698 st077697 3.79 67.5 µM 1.91E-5 8 7.50E-5 0.01
7 SGTC_1813 st051246 3.78 8.6 µM 2.06E-5 TSC3-RPN4 4 7.99E-5 0.60
8 SGTC_3288 9119690 3.65 36.2 µM 3.67E-5 20 1.31E-4 0.15
9 SGTC_1909 st060837 3.61 51.5 µM 4.40E-5 8 1.54E-4 0.04
10 SGTC_1032 k061-1018 3.61 98.7 µM 4.44E-5 10 1.55E-4 0.01
11 SGTC_2503 beta-caryophyllene alcohol 3.55 24.7 µM 5.68E-5 3 1.91E-4 0.18
12 SGTC_2714 st079313 3.54 56.9 µM 6.03E-5 10 2.01E-4 0.07
13 SGTC_3132 9126706 3.48 49.5 µM 7.71E-5 10 2.49E-4 0.14
14 SGTC_1816 st051957 3.38 91.6 µM 1.18E-4 4 3.58E-4 0.02
15 SGTC_1501 4491-0275 3.37 38.4 µM 1.22E-4 6 3.69E-4 0.08
16 SGTC_1962 st076595 3.30 64.5 µM 1.69E-4 redox potentiating 24 4.88E-4 0.08
17 SGTC_102 gallobenzophenone 3.26 83.6 µM 1.98E-4 redox potentiating 10 5.60E-4 0.08
18 SGTC_2200 6600604 3.13 21.9 µM 3.39E-4 tubulin folding & SWR complex 12 8.86E-4 0.09
19 SGTC_2792 7535235 3.06 81.8 µM 4.38E-4 fatty acid desaturase (OLE1) 27 0.00110 0.05
20 SGTC_632 0781-2353 3.05 4.7 µM 4.63E-4 Golgi 31 0.00116 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 3.22E-19 YLR105C SEN2 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
0.153 4.27E-19 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.145 3.60E-17 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.128 9.50E-14 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.125 3.12E-13 YBR193C MED8 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.125 3.19E-13 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.124 5.57E-13 YKL083W_d YKL083W_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
0.124 5.82E-13 YGR127W_p YGR127W_p hom Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
0.123 7.09E-13 YBL020W RFT1 het Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
0.120 2.77E-12 YER018C SPC25 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.119 5.32E-12 YCR013C_d YCR013C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.116 1.67E-11 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.114 4.03E-11 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.111 1.41E-10 YKL042W SPC42 het Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
0.106 8.12E-10 YER126C NSA2 het Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA