YGL146C_p / RRT6

Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL146C / RRT6

Click on Significant Values for Screen Details ID:SGTC_613|Compound:3914-0030|FD-Score:-3.18|P-value:2.35E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.43|P-value:7.99E-5 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.80|P-value:1.38E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:3.16|P-value:2.33E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.14|P-value:2.76E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.24|P-value:1.81E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.50|P-value:5.85E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:-2.98|P-value:5.11E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.75|P-value:1.12E-10 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.07|P-value:3.28E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-2.95|P-value:5.86E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:4.02|P-value:4.33E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.11|P-value:3.09E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-2.84|P-value:8.69E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.56|P-value:4.00E-5 ID:SGTC_1699|Compound:st031318|FD-Score:3.56|P-value:3.96E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-3.16|P-value:2.51E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.58|P-value:3.62E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.24|P-value:1.81E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.01|P-value:4.23E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-4.23|P-value:1.59E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-2.92|P-value:6.59E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.09|P-value:3.33E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-12.80|P-value:8.06E-46 ID:SGTC_2694|Compound:st077685|FD-Score:-3.99|P-value:5.48E-6 ID:SGTC_2780|Compound:5215298|FD-Score:2.82|P-value:8.85E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.10|P-value:2.97E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.01|P-value:4.57E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-4.06|P-value:3.88E-6 ID:SGTC_2996|Compound:9066192|FD-Score:-4.52|P-value:3.12E-7 ID:SGTC_3211|Compound:9128781|FD-Score:2.97|P-value:4.90E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.18|P-value:2.35E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.43|P-value:7.99E-5 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.80|P-value:1.38E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:3.16|P-value:2.33E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.14|P-value:2.76E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.24|P-value:1.81E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.50|P-value:5.85E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:-2.98|P-value:5.11E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.75|P-value:1.12E-10 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.07|P-value:3.28E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-2.95|P-value:5.86E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:4.02|P-value:4.33E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.11|P-value:3.09E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-2.84|P-value:8.69E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.56|P-value:4.00E-5 ID:SGTC_1699|Compound:st031318|FD-Score:3.56|P-value:3.96E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-3.16|P-value:2.51E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.58|P-value:3.62E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.24|P-value:1.81E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.01|P-value:4.23E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-4.23|P-value:1.59E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-2.92|P-value:6.59E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.09|P-value:3.33E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-12.80|P-value:8.06E-46 ID:SGTC_2694|Compound:st077685|FD-Score:-3.99|P-value:5.48E-6 ID:SGTC_2780|Compound:5215298|FD-Score:2.82|P-value:8.85E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.10|P-value:2.97E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.01|P-value:4.57E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-4.06|P-value:3.88E-6 ID:SGTC_2996|Compound:9066192|FD-Score:-4.52|P-value:3.12E-7 ID:SGTC_3211|Compound:9128781|FD-Score:2.97|P-value:4.90E-4

Top fitness defect scores for YGL146C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1209 2323-2347 4.02 50.3 µM 4.33E-6 16 2.96E-5
2 SGTC_2104 5389443 3.58 200.0 µM 3.62E-5 24 1.71E-4
3 SGTC_1699 st031318 3.56 29.1 µM 3.96E-5 29 1.84E-4
4 SGTC_1688 st021091 3.56 57.6 µM 4.00E-5 13 1.86E-4
5 SGTC_689 0833-0039 3.16 98.0 µM 2.33E-4 ergosterol depletion effects on membrane 54 7.96E-4
6 SGTC_2821 7996764 3.10 71.4 µM 2.97E-4 89 9.73E-4
7 SGTC_1134 3477-0009 3.07 42.5 µM 3.28E-4 90 0.00106
8 SGTC_2438 5259590 3.01 200.0 µM 4.23E-4 49 0.00131
9 SGTC_3211 9128781 2.97 49.5 µM 4.90E-4 129 0.00147
10 SGTC_2780 5215298 2.82 71.4 µM 8.85E-4 113 0.00240
11 SGTC_3080 9117754 2.78 49.5 µM 0.00101 73 0.00268
12 SGTC_3222 9128301 2.77 49.5 µM 0.00105 60S ribosome export 80 0.00276
13 SGTC_2832 7992762 2.75 52.0 µM 0.00114 93 0.00296
14 SGTC_2093 5331342 2.74 194.4 µM 0.00117 74 0.00304
15 SGTC_2526 patulin 2.72 37.6 µM 0.00127 197 0.00325
16 SGTC_2872 9044037 2.70 26.0 µM 0.00136 39 0.00344
17 SGTC_3162 9099653 2.70 49.5 µM 0.00138 50 0.00348
18 SGTC_2432 5630864 2.66 12.2 µM 0.00157 121 0.00386
19 SGTC_3092 9117248 2.64 49.5 µM 0.00168 cell wall signaling 38 0.00410
20 SGTC_2480 5767542 2.63 37.2 µM 0.00179 75 0.00431

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.448 1.64E-165 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.400 1.81E-129 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.396 1.59E-126 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.369 5.14E-109 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.347 9.26E-96 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.331 1.13E-86 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.316 2.54E-78 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.293 3.20E-67 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.289 1.73E-65 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.280 2.79E-61 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.256 1.94E-51 YGL144C ROG1 hom Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
0.256 3.01E-51 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.251 3.56E-49 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.249 8.48E-49 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.248 2.54E-48 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother