YGL148W / ARO2

Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL148W / ARO2

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:4.56|P-value:4.07E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.62|P-value:3.46E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.06|P-value:1.81E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.91|P-value:8.10E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.52|P-value:2.55E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.55|P-value:1.08E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:4.30|P-value:8.09E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.21|P-value:6.21E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:7.37|P-value:2.42E-8 ID:SGTC_515|Compound:4092-1064|FD-Score:4.35|P-value:7.11E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:4.54|P-value:4.33E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:9.63|P-value:4.12E-13 ID:SGTC_638|Compound:3970-0837|FD-Score:6.61|P-value:5.02E-7 ID:SGTC_706|Compound:4262-0057|FD-Score:5.81|P-value:8.98E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:8.65|P-value:6.78E-11 ID:SGTC_805|Compound:3852-0218|FD-Score:4.38|P-value:6.53E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:8.93|P-value:1.62E-11 ID:SGTC_912|Compound:3474-0017|FD-Score:5.99|P-value:4.88E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.57|P-value:2.22E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.95|P-value:1.34E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:4.49|P-value:4.97E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.85|P-value:1.83E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.45|P-value:5.48E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.97|P-value:1.68E-9 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.48|P-value:2.85E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:5.63|P-value:1.62E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.79|P-value:2.57E-7 ID:SGTC_1159|Compound:4092-0538|FD-Score:5.03|P-value:1.08E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.68|P-value:2.94E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:5.54|P-value:2.20E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:9.42|P-value:1.30E-12 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.81|P-value:2.02E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-4.52|P-value:2.52E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.33|P-value:7.38E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.69|P-value:2.82E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:7.43|P-value:1.82E-8 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.37|P-value:6.67E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.59|P-value:1.89E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:6.76|P-value:2.86E-7 ID:SGTC_1519|Compound:esterone|FD-Score:5.04|P-value:1.04E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:8.43|P-value:2.00E-10 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:8.09|P-value:9.96E-10 ID:SGTC_1636|Compound:st007707|FD-Score:4.80|P-value:2.10E-4 ID:SGTC_1638|Compound:st008370|FD-Score:7.59|P-value:9.15E-9 ID:SGTC_1649|Compound:st011737|FD-Score:4.77|P-value:2.29E-4 ID:SGTC_1655|Compound:st012546|FD-Score:5.45|P-value:2.96E-5 ID:SGTC_1656|Compound:st012921|FD-Score:14.20|P-value:1.37E-26 ID:SGTC_1672|Compound:st016598|FD-Score:6.87|P-value:1.87E-7 ID:SGTC_1715|Compound:st032160|FD-Score:5.46|P-value:2.82E-5 ID:SGTC_1750|Compound:st081859|FD-Score:11.10|P-value:5.97E-17 ID:SGTC_1797|Compound:st048695|FD-Score:5.20|P-value:6.44E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.75|P-value:2.44E-4 ID:SGTC_1937|Compound:st074714|FD-Score:6.19|P-value:2.37E-6 ID:SGTC_2038|Compound:4100038|FD-Score:8.86|P-value:2.38E-11 ID:SGTC_2093|Compound:5331342|FD-Score:6.90|P-value:1.66E-7 ID:SGTC_2132|Compound:5317594|FD-Score:5.72|P-value:1.23E-5 ID:SGTC_2164|Compound:5685496|FD-Score:4.24|P-value:9.44E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:7.67|P-value:6.44E-9 ID:SGTC_2322|Compound:7413319|FD-Score:5.31|P-value:4.52E-5 ID:SGTC_2357|Compound:9067248|FD-Score:4.97|P-value:1.27E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:7.12|P-value:6.75E-8 ID:SGTC_2433|Compound:5607874|FD-Score:4.76|P-value:2.34E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.94|P-value:1.39E-4 ID:SGTC_2472|Compound:5377652|FD-Score:5.04|P-value:1.05E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:11.70|P-value:1.44E-18 ID:SGTC_2544|Compound:sphondin|FD-Score:-4.14|P-value:7.03E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.48|P-value:5.09E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:12.10|P-value:1.12E-19 ID:SGTC_2618|Compound:avocadyne|FD-Score:5.46|P-value:2.86E-5 ID:SGTC_2699|Compound:st077704|FD-Score:9.90|P-value:9.17E-14 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:6.35|P-value:1.33E-6 ID:SGTC_2790|Compound:5423970|FD-Score:6.47|P-value:8.57E-7 ID:SGTC_2851|Compound:9015922|FD-Score:4.79|P-value:2.15E-4 ID:SGTC_2852|Compound:9023854|FD-Score:4.24|P-value:9.54E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-8.84|P-value:8.87E-12 ID:SGTC_2859|Compound:9028643|FD-Score:-4.85|P-value:9.77E-5 ID:SGTC_2887|Compound:9044784|FD-Score:9.43|P-value:1.17E-12 ID:SGTC_2890|Compound:9046729|FD-Score:4.31|P-value:7.82E-4 ID:SGTC_2893|Compound:9048488|FD-Score:4.40|P-value:6.26E-4 ID:SGTC_2897|Compound:9048598|FD-Score:8.93|P-value:1.67E-11 ID:SGTC_2902|Compound:5787006|FD-Score:-4.38|P-value:3.70E-4 ID:SGTC_2910|Compound:7948405|FD-Score:5.53|P-value:2.30E-5 ID:SGTC_2948|Compound:9070189|FD-Score:7.34|P-value:2.72E-8 ID:SGTC_2976|Compound:9009005|FD-Score:9.13|P-value:5.81E-12 ID:SGTC_3058|Compound:9093861|FD-Score:4.91|P-value:1.50E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.26|P-value:8.95E-4 ID:SGTC_3073|Compound:9114972|FD-Score:5.64|P-value:1.58E-5 ID:SGTC_3077|Compound:9117319|FD-Score:4.31|P-value:7.81E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.72|P-value:2.64E-4 ID:SGTC_3189|Compound:9110682|FD-Score:5.98|P-value:5.11E-6 ID:SGTC_3197|Compound:9113331|FD-Score:5.72|P-value:1.23E-5 ID:SGTC_3214|Compound:9129694|FD-Score:5.14|P-value:7.80E-5 ID:SGTC_3308|Compound:9128332|FD-Score:7.32|P-value:2.89E-8 ID:SGTC_21|Compound:0849-0113|FD-Score:4.56|P-value:4.07E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.62|P-value:3.46E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.06|P-value:1.81E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.91|P-value:8.10E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.52|P-value:2.55E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.55|P-value:1.08E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:4.30|P-value:8.09E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.21|P-value:6.21E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:7.37|P-value:2.42E-8 ID:SGTC_515|Compound:4092-1064|FD-Score:4.35|P-value:7.11E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:4.54|P-value:4.33E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:9.63|P-value:4.12E-13 ID:SGTC_638|Compound:3970-0837|FD-Score:6.61|P-value:5.02E-7 ID:SGTC_706|Compound:4262-0057|FD-Score:5.81|P-value:8.98E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:8.65|P-value:6.78E-11 ID:SGTC_805|Compound:3852-0218|FD-Score:4.38|P-value:6.53E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:8.93|P-value:1.62E-11 ID:SGTC_912|Compound:3474-0017|FD-Score:5.99|P-value:4.88E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.57|P-value:2.22E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.95|P-value:1.34E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:4.49|P-value:4.97E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.85|P-value:1.83E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.45|P-value:5.48E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.97|P-value:1.68E-9 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.48|P-value:2.85E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:5.63|P-value:1.62E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.79|P-value:2.57E-7 ID:SGTC_1159|Compound:4092-0538|FD-Score:5.03|P-value:1.08E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.68|P-value:2.94E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:5.54|P-value:2.20E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:9.42|P-value:1.30E-12 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.81|P-value:2.02E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-4.52|P-value:2.52E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.33|P-value:7.38E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.69|P-value:2.82E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:7.43|P-value:1.82E-8 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.37|P-value:6.67E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.59|P-value:1.89E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:6.76|P-value:2.86E-7 ID:SGTC_1519|Compound:esterone|FD-Score:5.04|P-value:1.04E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:8.43|P-value:2.00E-10 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:8.09|P-value:9.96E-10 ID:SGTC_1636|Compound:st007707|FD-Score:4.80|P-value:2.10E-4 ID:SGTC_1638|Compound:st008370|FD-Score:7.59|P-value:9.15E-9 ID:SGTC_1649|Compound:st011737|FD-Score:4.77|P-value:2.29E-4 ID:SGTC_1655|Compound:st012546|FD-Score:5.45|P-value:2.96E-5 ID:SGTC_1656|Compound:st012921|FD-Score:14.20|P-value:1.37E-26 ID:SGTC_1672|Compound:st016598|FD-Score:6.87|P-value:1.87E-7 ID:SGTC_1715|Compound:st032160|FD-Score:5.46|P-value:2.82E-5 ID:SGTC_1750|Compound:st081859|FD-Score:11.10|P-value:5.97E-17 ID:SGTC_1797|Compound:st048695|FD-Score:5.20|P-value:6.44E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.75|P-value:2.44E-4 ID:SGTC_1937|Compound:st074714|FD-Score:6.19|P-value:2.37E-6 ID:SGTC_2038|Compound:4100038|FD-Score:8.86|P-value:2.38E-11 ID:SGTC_2093|Compound:5331342|FD-Score:6.90|P-value:1.66E-7 ID:SGTC_2132|Compound:5317594|FD-Score:5.72|P-value:1.23E-5 ID:SGTC_2164|Compound:5685496|FD-Score:4.24|P-value:9.44E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:7.67|P-value:6.44E-9 ID:SGTC_2322|Compound:7413319|FD-Score:5.31|P-value:4.52E-5 ID:SGTC_2357|Compound:9067248|FD-Score:4.97|P-value:1.27E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:7.12|P-value:6.75E-8 ID:SGTC_2433|Compound:5607874|FD-Score:4.76|P-value:2.34E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.94|P-value:1.39E-4 ID:SGTC_2472|Compound:5377652|FD-Score:5.04|P-value:1.05E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:11.70|P-value:1.44E-18 ID:SGTC_2544|Compound:sphondin|FD-Score:-4.14|P-value:7.03E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.48|P-value:5.09E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:12.10|P-value:1.12E-19 ID:SGTC_2618|Compound:avocadyne|FD-Score:5.46|P-value:2.86E-5 ID:SGTC_2699|Compound:st077704|FD-Score:9.90|P-value:9.17E-14 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:6.35|P-value:1.33E-6 ID:SGTC_2790|Compound:5423970|FD-Score:6.47|P-value:8.57E-7 ID:SGTC_2851|Compound:9015922|FD-Score:4.79|P-value:2.15E-4 ID:SGTC_2852|Compound:9023854|FD-Score:4.24|P-value:9.54E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-8.84|P-value:8.87E-12 ID:SGTC_2859|Compound:9028643|FD-Score:-4.85|P-value:9.77E-5 ID:SGTC_2887|Compound:9044784|FD-Score:9.43|P-value:1.17E-12 ID:SGTC_2890|Compound:9046729|FD-Score:4.31|P-value:7.82E-4 ID:SGTC_2893|Compound:9048488|FD-Score:4.40|P-value:6.26E-4 ID:SGTC_2897|Compound:9048598|FD-Score:8.93|P-value:1.67E-11 ID:SGTC_2902|Compound:5787006|FD-Score:-4.38|P-value:3.70E-4 ID:SGTC_2910|Compound:7948405|FD-Score:5.53|P-value:2.30E-5 ID:SGTC_2948|Compound:9070189|FD-Score:7.34|P-value:2.72E-8 ID:SGTC_2976|Compound:9009005|FD-Score:9.13|P-value:5.81E-12 ID:SGTC_3058|Compound:9093861|FD-Score:4.91|P-value:1.50E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.26|P-value:8.95E-4 ID:SGTC_3073|Compound:9114972|FD-Score:5.64|P-value:1.58E-5 ID:SGTC_3077|Compound:9117319|FD-Score:4.31|P-value:7.81E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.72|P-value:2.64E-4 ID:SGTC_3189|Compound:9110682|FD-Score:5.98|P-value:5.11E-6 ID:SGTC_3197|Compound:9113331|FD-Score:5.72|P-value:1.23E-5 ID:SGTC_3214|Compound:9129694|FD-Score:5.14|P-value:7.80E-5 ID:SGTC_3308|Compound:9128332|FD-Score:7.32|P-value:2.89E-8

Top fitness defect scores for YGL148W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1656 st012921 14.20 11.0 µM 1.37E-26 5 3.54E-46
2 SGTC_2607 solasodine 12.10 47.4 µM 1.12E-19 11 6.69E-34
3 SGTC_2540 epiandrosterone 11.70 100.0 µM 1.44E-18 9 6.28E-32
4 SGTC_1750 st081859 11.10 2.4 µM 5.97E-17 endomembrane recycling 34 4.68E-29
5 SGTC_2699 st077704 9.90 54.6 µM 9.17E-14 endomembrane recycling 7 2.13E-23
6 SGTC_637 1181-0519 9.63 7.3 µM 4.12E-13 fatty acid desaturase (OLE1) 22 3.06E-22
7 SGTC_2887 9044784 9.43 58.4 µM 1.17E-12 fatty acid desaturase (OLE1) 4 1.97E-21
8 SGTC_1213 1315-0166 9.42 115.0 µM 1.30E-12 3 2.36E-21
9 SGTC_2976 9009005 9.13 19.5 µM 5.81E-12 7 3.37E-20
10 SGTC_819 1013-0258 8.93 27.7 µM 1.62E-11 10 2.08E-19
11 SGTC_2897 9048598 8.93 13.0 µM 1.67E-11 1 2.19E-19
12 SGTC_2038 4100038 8.86 31.0 µM 2.38E-11 plasma membrane duress 15 4.10E-19
13 SGTC_768 0384-0033 8.65 77.3 µM 6.78E-11 fatty acid desaturase (OLE1) 19 2.63E-18
14 SGTC_1572 epiandrosterone 8.43 68.9 µM 2.00E-10 10 1.79E-17
15 SGTC_1597 7-benzyloxygramine 8.09 47.5 µM 9.96E-10 calcium & mitochondrial duress 24 3.09E-16
16 SGTC_1026 k007-1105 7.97 30.6 µM 1.68E-9 ERAD & cell cycle 17 7.78E-16
17 SGTC_2232 chlorophetanol 7.67 41.5 µM 6.44E-9 TRP & mitochondrial translation 22 8.45E-15
18 SGTC_1638 st008370 7.59 60.6 µM 9.15E-9 ergosterol biosynthesis 6 1.57E-14
19 SGTC_1455 4262-0120 7.43 131.0 µM 1.82E-8 plasma membrane duress 6 5.32E-14
20 SGTC_505 gw-5074 7.37 63.9 µM 2.42E-8 20 8.83E-14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.478 7.09E-190 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.397 9.11E-127 YGL026C TRP5 hom Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
0.394 4.71E-125 YDR007W TRP1 hom Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
0.388 1.75E-120 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.372 6.83E-110 YDR008C_d YDR008C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.362 2.10E-104 YKR026C GCN3 hom Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
0.341 6.65E-92 YDR283C GCN2 hom Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
0.336 1.14E-88 YER090W TRP2 hom Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
0.332 9.31E-87 YDR354W TRP4 hom Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
0.292 8.46E-67 YEL009C GCN4 hom Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
0.262 1.49E-53 YFR009W GCN20 hom Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
0.239 9.00E-45 YDR035W ARO3 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
0.238 2.98E-44 YCR094W CDC50 hom Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.231 5.57E-42 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.226 5.84E-40 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth