YGL150C / INO80

ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL150C / INO80

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:3.71|P-value:3.67E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.78|P-value:5.09E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:4.53|P-value:1.82E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-5.63|P-value:1.00E-7 ID:SGTC_325|Compound:2810-4341|FD-Score:3.73|P-value:3.37E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-4.09|P-value:7.85E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:4.77|P-value:6.74E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:-4.41|P-value:2.30E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.54|P-value:1.75E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:3.94|P-value:1.66E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:-4.73|P-value:6.20E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.41|P-value:8.03E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.72|P-value:3.54E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:5.27|P-value:7.38E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.99|P-value:1.40E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.78|P-value:5.06E-6 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-3.71|P-value:2.98E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-3.64|P-value:3.76E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.59|P-value:5.45E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-4.61|P-value:1.04E-5 ID:SGTC_2009|Compound:4012297|FD-Score:7.91|P-value:2.29E-13 ID:SGTC_2053|Compound:5265679|FD-Score:-3.77|P-value:2.40E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.75|P-value:3.13E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.77|P-value:2.42E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.40|P-value:9.95E-4 ID:SGTC_2482|Compound:5981709|FD-Score:4.23|P-value:5.79E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.78|P-value:2.85E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:-3.43|P-value:7.36E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.40|P-value:8.05E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.86|P-value:4.68E-6 ID:SGTC_2789|Compound:5281112|FD-Score:5.13|P-value:1.39E-6 ID:SGTC_2928|Compound:9011484|FD-Score:-4.59|P-value:1.10E-5 ID:SGTC_2937|Compound:9044753|FD-Score:3.72|P-value:3.52E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.50|P-value:2.04E-5 ID:SGTC_3143|Compound:9086658|FD-Score:5.23|P-value:9.16E-7 ID:SGTC_3180|Compound:9109287|FD-Score:-3.44|P-value:7.22E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.84|P-value:1.89E-4 ID:SGTC_3243|Compound:9134147|FD-Score:3.62|P-value:4.89E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.71|P-value:3.67E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.78|P-value:5.09E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:4.53|P-value:1.82E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-5.63|P-value:1.00E-7 ID:SGTC_325|Compound:2810-4341|FD-Score:3.73|P-value:3.37E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-4.09|P-value:7.85E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:4.77|P-value:6.74E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:-4.41|P-value:2.30E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.54|P-value:1.75E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:3.94|P-value:1.66E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:-4.73|P-value:6.20E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.41|P-value:8.03E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.72|P-value:3.54E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:5.27|P-value:7.38E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.99|P-value:1.40E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.78|P-value:5.06E-6 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-3.71|P-value:2.98E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-3.64|P-value:3.76E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.59|P-value:5.45E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-4.61|P-value:1.04E-5 ID:SGTC_2009|Compound:4012297|FD-Score:7.91|P-value:2.29E-13 ID:SGTC_2053|Compound:5265679|FD-Score:-3.77|P-value:2.40E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.75|P-value:3.13E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.77|P-value:2.42E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.40|P-value:9.95E-4 ID:SGTC_2482|Compound:5981709|FD-Score:4.23|P-value:5.79E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.78|P-value:2.85E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:-3.43|P-value:7.36E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.40|P-value:8.05E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.86|P-value:4.68E-6 ID:SGTC_2789|Compound:5281112|FD-Score:5.13|P-value:1.39E-6 ID:SGTC_2928|Compound:9011484|FD-Score:-4.59|P-value:1.10E-5 ID:SGTC_2937|Compound:9044753|FD-Score:3.72|P-value:3.52E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.50|P-value:2.04E-5 ID:SGTC_3143|Compound:9086658|FD-Score:5.23|P-value:9.16E-7 ID:SGTC_3180|Compound:9109287|FD-Score:-3.44|P-value:7.22E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.84|P-value:1.89E-4 ID:SGTC_3243|Compound:9134147|FD-Score:3.62|P-value:4.89E-4

Top fitness defect scores for YGL150C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2009 4012297 7.91 12.1 µM 2.29E-13 cell wall signaling 3 1.27E-15 2.47
2 SGTC_1010 4112-3296 5.27 15.2 µM 7.38E-7 4 6.69E-8 0.97
3 SGTC_3143 9086658 5.23 49.5 µM 9.16E-7 6 8.65E-8 0.78
4 SGTC_2789 5281112 5.13 71.4 µM 1.39E-6 4 1.42E-7 0.82
5 SGTC_2783 7738165 4.86 71.4 µM 4.68E-6 2 5.97E-7 0.50
6 SGTC_339 3091-4833 4.77 71.4 µM 6.74E-6 iron homeostasis 5 9.22E-7 0.05
7 SGTC_453 enantio-paf c16 4.54 10.0 µM 1.75E-5 17 2.85E-6 0.10
8 SGTC_163 1327-0036 4.53 7.5 µM 1.82E-5 40 2.99E-6 0.03
9 SGTC_3063 1327-0034 4.50 4.0 µM 2.04E-5 6 3.42E-6 0.02
10 SGTC_2482 5981709 4.23 142.7 µM 5.79E-5 PDR1 12 1.18E-5 0.11
11 SGTC_1014 4130-3005 3.99 69.3 µM 1.40E-4 6 3.35E-5 0.06
12 SGTC_455 paf C-16 3.94 10.0 µM 1.66E-4 7 4.09E-5 0.27
13 SGTC_2540 epiandrosterone 3.78 100.0 µM 2.85E-4 3 7.77E-5 0.05
14 SGTC_2059 5238311 3.75 157.0 µM 3.13E-4 6 8.67E-5 0.02
15 SGTC_325 2810-4341 3.73 181.0 µM 3.37E-4 amide catabolism 8 9.47E-5 0.12
16 SGTC_2937 9044753 3.72 11.3 µM 3.52E-4 60S ribosome export 10 9.97E-5 0.04
17 SGTC_965 1291-5240 3.72 308.0 µM 3.54E-4 5 1.00E-4 0.26
18 SGTC_59 0330-0160 3.71 1.3 µM 3.67E-4 6 1.05E-4 0.22
19 SGTC_3243 9134147 3.62 49.5 µM 4.89E-4 4 1.47E-4 0.12
20 SGTC_1997 st073024 3.59 93.8 µM 5.45E-4 5 1.67E-4 0.42

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 6.77E-23 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.140 4.58E-16 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.113 5.45E-11 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.112 7.30E-11 YER022W SRB4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination
0.112 8.49E-11 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.107 5.77E-10 YDR201W SPC19 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
0.103 2.43E-9 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.103 2.45E-9 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.102 3.24E-9 YDL188C PPH22 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
0.101 4.36E-9 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.101 4.82E-9 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.100 6.06E-9 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.099 8.54E-9 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.098 1.09E-8 YKR039W GAP1 hom General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth
0.097 1.74E-8 YGR192C TDH3 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication