YGL152C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL152C / YGL152C

Click on Significant Values for Screen Details ID:SGTC_162|Compound:k030-0015|FD-Score:4.38|P-value:1.33E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:4.35|P-value:1.48E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.27|P-value:7.50E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-4.38|P-value:1.10E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.71|P-value:1.89E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.28|P-value:8.43E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.60|P-value:2.43E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.67|P-value:1.84E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.70|P-value:1.99E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.35|P-value:6.61E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-4.09|P-value:3.69E-5 ID:SGTC_2175|Compound:5807670|FD-Score:-3.66|P-value:1.92E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-5.42|P-value:7.89E-8 ID:SGTC_2186|Compound:6124449|FD-Score:-3.19|P-value:9.86E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.78|P-value:1.44E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.35|P-value:6.72E-4 ID:SGTC_2694|Compound:st077685|FD-Score:3.35|P-value:6.63E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:4.38|P-value:1.33E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:4.35|P-value:1.48E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.27|P-value:7.50E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-4.38|P-value:1.10E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.71|P-value:1.89E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.28|P-value:8.43E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.60|P-value:2.43E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.67|P-value:1.84E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.70|P-value:1.99E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.35|P-value:6.61E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-4.09|P-value:3.69E-5 ID:SGTC_2175|Compound:5807670|FD-Score:-3.66|P-value:1.92E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-5.42|P-value:7.89E-8 ID:SGTC_2186|Compound:6124449|FD-Score:-3.19|P-value:9.86E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.78|P-value:1.44E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.35|P-value:6.72E-4 ID:SGTC_2694|Compound:st077685|FD-Score:3.35|P-value:6.63E-4

Top fitness defect scores for YGL152C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_162 k030-0015 4.38 37.8 µM 1.33E-5 iron homeostasis 17 5.97E-6
2 SGTC_170 4197-0004 4.35 226.0 µM 1.48E-5 13 6.71E-6
3 SGTC_2404 5161160 3.78 200.0 µM 1.44E-4 25 7.77E-5
4 SGTC_1308 1187-1617 3.71 41.4 µM 1.89E-4 fatty acid desaturase (OLE1) 48 1.04E-4
5 SGTC_2016 5121758 3.70 140.0 µM 1.99E-4 redox potentiating 63 1.10E-4
6 SGTC_2081 5214970 3.35 32.3 µM 6.61E-4 44 4.00E-4
7 SGTC_2694 st077685 3.35 81.9 µM 6.63E-4 endomembrane recycling 47 4.02E-4
8 SGTC_2587 piperic acid 3.35 92.2 µM 6.72E-4 39 4.07E-4
9 SGTC_1439 4092-1168 3.28 46.0 µM 8.43E-4 24 5.21E-4
10 SGTC_555 4296-0685 3.15 37.0 µM 0.00127 ergosterol biosynthesis 33 8.12E-4
11 SGTC_2607 solasodine 3.11 47.4 µM 0.00147 94 9.47E-4
12 SGTC_132 0417-1715 3.06 25.8 µM 0.00172 RPP1 & pyrimidine depletion 49 0.00112
13 SGTC_389 tpck 3.04 16.7 µM 0.00183 72 0.00120
14 SGTC_1572 epiandrosterone 2.99 68.9 µM 0.00208 62 0.00137
15 SGTC_508 roscovitine 2.98 141.0 µM 0.00218 26 0.00145
16 SGTC_309 k408-0051 2.96 1.5 µM 0.00232 128 0.00155
17 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 2.95 44.4 nM 0.00236 DNA damage response 71 0.00158
18 SGTC_733 4069-0007 2.86 56.1 µM 0.00308 ERAD & cell cycle 164 0.00210
19 SGTC_719 2810-4230 2.83 27.3 µM 0.00341 26 0.00234
20 SGTC_2180 6301957 2.83 200.0 µM 0.00341 RSC complex & mRNA processing 35 0.00235

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.204 6.34E-33 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.199 2.33E-31 YAL066W_d YAL066W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.179 1.55E-25 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.169 5.97E-23 YDR165W TRM82 hom Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.164 1.11E-21 YFR026C ULI1 hom Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
0.162 3.45E-21 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.150 2.49E-18 YKR017C HEL1 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)
0.139 7.09E-16 YLR406C-A_p YLR406C-A_p hom Putative protein of unknown function
0.127 1.80E-13 YKL161C KDX1 hom Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p
0.116 1.40E-11 YOL138C RTC1 hom Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif
0.116 1.73E-11 YLR296W_d YLR296W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.112 9.55E-11 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.108 3.43E-10 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.105 1.07E-9 YKL164C PIR1 hom O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.100 7.01E-9 YEL072W RMD6 hom Protein required for sporulation