YGL154C / LYS5

Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL154C / LYS5

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:-2.85|P-value:9.27E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.02|P-value:4.81E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-2.90|P-value:7.62E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.22|P-value:1.97E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.08|P-value:3.79E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:2.82|P-value:9.63E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.67|P-value:2.69E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:2.91|P-value:6.88E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-2.99|P-value:5.46E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-4.14|P-value:2.98E-6 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.16|P-value:2.81E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:2.84|P-value:8.99E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.70|P-value:2.38E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.64|P-value:3.12E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.03|P-value:4.75E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.04|P-value:4.17E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.61|P-value:3.60E-5 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.18|P-value:2.33E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.93|P-value:6.87E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.94|P-value:6.59E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.73|P-value:2.04E-5 ID:SGTC_1626|Compound:st003712|FD-Score:5.45|P-value:1.10E-9 ID:SGTC_1732|Compound:st034308|FD-Score:-3.88|P-value:1.12E-5 ID:SGTC_1761|Compound:st044296|FD-Score:-3.18|P-value:2.61E-4 ID:SGTC_1848|Compound:st056003|FD-Score:-3.02|P-value:4.80E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.90|P-value:9.24E-6 ID:SGTC_2135|Compound:5326629|FD-Score:-3.20|P-value:2.40E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-2.95|P-value:6.30E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.70|P-value:2.34E-5 ID:SGTC_2309|Compound:7664088|FD-Score:4.15|P-value:2.54E-6 ID:SGTC_2483|Compound:5729050|FD-Score:3.01|P-value:4.64E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.80|P-value:1.48E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:2.83|P-value:9.25E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.79|P-value:1.53E-5 ID:SGTC_2493|Compound:resveratrol|FD-Score:4.19|P-value:2.13E-6 ID:SGTC_2853|Compound:9015042|FD-Score:-2.84|P-value:9.63E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-2.93|P-value:6.88E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:2.84|P-value:9.04E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-3.58|P-value:4.61E-5 ID:SGTC_3186|Compound:9110464|FD-Score:3.53|P-value:5.29E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-2.96|P-value:6.17E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.78|P-value:7.81E-8 ID:SGTC_13|Compound:0199-0087|FD-Score:-2.85|P-value:9.27E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.02|P-value:4.81E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-2.90|P-value:7.62E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.22|P-value:1.97E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.08|P-value:3.79E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:2.82|P-value:9.63E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.67|P-value:2.69E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:2.91|P-value:6.88E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-2.99|P-value:5.46E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-4.14|P-value:2.98E-6 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.16|P-value:2.81E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:2.84|P-value:8.99E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.70|P-value:2.38E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.64|P-value:3.12E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.03|P-value:4.75E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.04|P-value:4.17E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.61|P-value:3.60E-5 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.18|P-value:2.33E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.93|P-value:6.87E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.94|P-value:6.59E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.73|P-value:2.04E-5 ID:SGTC_1626|Compound:st003712|FD-Score:5.45|P-value:1.10E-9 ID:SGTC_1732|Compound:st034308|FD-Score:-3.88|P-value:1.12E-5 ID:SGTC_1761|Compound:st044296|FD-Score:-3.18|P-value:2.61E-4 ID:SGTC_1848|Compound:st056003|FD-Score:-3.02|P-value:4.80E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.90|P-value:9.24E-6 ID:SGTC_2135|Compound:5326629|FD-Score:-3.20|P-value:2.40E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-2.95|P-value:6.30E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.70|P-value:2.34E-5 ID:SGTC_2309|Compound:7664088|FD-Score:4.15|P-value:2.54E-6 ID:SGTC_2483|Compound:5729050|FD-Score:3.01|P-value:4.64E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.80|P-value:1.48E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:2.83|P-value:9.25E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.79|P-value:1.53E-5 ID:SGTC_2493|Compound:resveratrol|FD-Score:4.19|P-value:2.13E-6 ID:SGTC_2853|Compound:9015042|FD-Score:-2.84|P-value:9.63E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-2.93|P-value:6.88E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:2.84|P-value:9.04E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-3.58|P-value:4.61E-5 ID:SGTC_3186|Compound:9110464|FD-Score:3.53|P-value:5.29E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-2.96|P-value:6.17E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.78|P-value:7.81E-8

Top fitness defect scores for YGL154C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1626 st003712 5.45 1.8 µM 1.10E-9 9 2.56E-8
2 SGTC_3304 9125678 4.78 46.1 µM 7.81E-8 25 8.97E-7
3 SGTC_2493 resveratrol 4.19 26.1 µM 2.13E-6 5 1.43E-5
4 SGTC_2309 7664088 4.15 163.9 µM 2.54E-6 20 1.65E-5
5 SGTC_1911 st060208 3.90 74.3 µM 9.24E-6 36 4.87E-5
6 SGTC_2490 carminic acid 3.80 95.4 µM 1.48E-5 7 7.21E-5
7 SGTC_2492 derrusnin 3.79 100.0 µM 1.53E-5 7 7.43E-5
8 SGTC_1557 sumaresinolic acid 3.73 42.3 µM 2.04E-5 24 9.45E-5
9 SGTC_2308 7584454 3.70 197.6 µM 2.34E-5 28 1.06E-4
10 SGTC_1009 4106-0057 3.70 9.9 µM 2.38E-5 20 1.07E-4
11 SGTC_362 0310-0100 3.67 9.0 µM 2.69E-5 RPP1 & pyrimidine depletion 42 1.19E-4
12 SGTC_1091 telmisartan 3.64 47.6 µM 3.12E-5 22 1.35E-4
13 SGTC_1262 0737-0114 3.61 49.6 µM 3.60E-5 30 1.52E-4
14 SGTC_3186 9110464 3.53 49.5 µM 5.29E-5 RPP1 & pyrimidine depletion 22 2.10E-4
15 SGTC_183 3914-0051 3.22 30.6 µM 1.97E-4 60S ribosome export 50 6.33E-4
16 SGTC_1323 1348-1351 3.18 11.2 µM 2.33E-4 22 7.30E-4
17 SGTC_1176 0848-0131 3.04 83.3 µM 4.17E-4 Golgi 57 0.00119
18 SGTC_2483 5729050 3.01 27.2 µM 4.64E-4 68 0.00130
19 SGTC_426 0988-0037 2.91 14.6 µM 6.88E-4 ERAD & cell cycle 90 0.00181
20 SGTC_822 1487-0950 2.84 154.0 µM 8.99E-4 59 0.00227

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 5.57E-27 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.182 2.34E-26 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.158 2.66E-20 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.149 3.28E-18 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.148 7.74E-18 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.146 1.70E-17 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.139 6.75E-16 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress
0.133 1.01E-14 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.133 1.36E-14 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.123 8.36E-13 YER109C FLO8 hom Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
0.113 4.96E-11 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.108 3.38E-10 YLR230W_d YLR230W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
0.104 1.58E-9 YGL097W SRM1 het Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
0.102 2.79E-9 YLR189C ATG26 hom UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.099 8.31E-9 YKR060W UTP30 hom Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit