YGL156W / AMS1

Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL156W / AMS1

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.87|P-value:3.70E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.72|P-value:6.40E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.84|P-value:3.07E-7 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.46|P-value:1.81E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.24|P-value:4.56E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.07|P-value:8.52E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.36|P-value:3.01E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.14|P-value:6.77E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.49|P-value:1.60E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-5.03|P-value:1.13E-7 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.04|P-value:8.59E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.79|P-value:5.39E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.46|P-value:2.01E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.29|P-value:3.47E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.27|P-value:4.13E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.63|P-value:1.04E-4 ID:SGTC_1668|Compound:st014914|FD-Score:-3.43|P-value:2.04E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.16|P-value:6.10E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.19|P-value:4.92E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.52|P-value:1.44E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.09|P-value:7.07E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.23|P-value:4.75E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.25|P-value:6.81E-6 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.37|P-value:2.52E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.45|P-value:1.87E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.10|P-value:7.62E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.70|P-value:7.49E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.72|P-value:6.68E-7 ID:SGTC_2427|Compound:5545055|FD-Score:3.38|P-value:2.78E-4 ID:SGTC_2465|Compound:5809242|FD-Score:3.10|P-value:7.77E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.03|P-value:8.76E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.03|P-value:9.86E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.37|P-value:3.84E-6 ID:SGTC_2857|Compound:9024691|FD-Score:5.60|P-value:4.78E-9 ID:SGTC_2859|Compound:9028643|FD-Score:-4.13|P-value:1.03E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-3.11|P-value:6.76E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.56|P-value:1.38E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.70|P-value:7.83E-5 ID:SGTC_3198|Compound:9112019|FD-Score:3.27|P-value:4.20E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-4.21|P-value:7.05E-6 ID:SGTC_37|Compound:0566-0070|FD-Score:3.87|P-value:3.70E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.72|P-value:6.40E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.84|P-value:3.07E-7 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.46|P-value:1.81E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.24|P-value:4.56E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.07|P-value:8.52E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.36|P-value:3.01E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.14|P-value:6.77E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.49|P-value:1.60E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-5.03|P-value:1.13E-7 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.04|P-value:8.59E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.79|P-value:5.39E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.46|P-value:2.01E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.29|P-value:3.47E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.27|P-value:4.13E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.63|P-value:1.04E-4 ID:SGTC_1668|Compound:st014914|FD-Score:-3.43|P-value:2.04E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.16|P-value:6.10E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.19|P-value:4.92E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.52|P-value:1.44E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.09|P-value:7.07E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.23|P-value:4.75E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.25|P-value:6.81E-6 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.37|P-value:2.52E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.45|P-value:1.87E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.10|P-value:7.62E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.70|P-value:7.49E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.72|P-value:6.68E-7 ID:SGTC_2427|Compound:5545055|FD-Score:3.38|P-value:2.78E-4 ID:SGTC_2465|Compound:5809242|FD-Score:3.10|P-value:7.77E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.03|P-value:8.76E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.03|P-value:9.86E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.37|P-value:3.84E-6 ID:SGTC_2857|Compound:9024691|FD-Score:5.60|P-value:4.78E-9 ID:SGTC_2859|Compound:9028643|FD-Score:-4.13|P-value:1.03E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-3.11|P-value:6.76E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.56|P-value:1.38E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.70|P-value:7.83E-5 ID:SGTC_3198|Compound:9112019|FD-Score:3.27|P-value:4.20E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-4.21|P-value:7.05E-6

Top fitness defect scores for YGL156W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2857 9024691 5.60 58.4 µM 4.78E-9 5 1.05E-8
2 SGTC_2419 paclitaxel 4.72 166.5 µM 6.68E-7 21 1.16E-6
3 SGTC_2417 cerulenin 4.70 830.0 nM 7.49E-7 15 1.29E-6
4 SGTC_2607 solasodine 4.37 47.4 µM 3.84E-6 46 6.16E-6
5 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.25 70.1 µM 6.81E-6 17 1.06E-5
6 SGTC_37 0566-0070 3.87 1.6 µM 3.70E-5 29 5.34E-5
7 SGTC_962 1254-0300 3.79 21.5 µM 5.39E-5 29 7.65E-5
8 SGTC_3191 9110352 3.70 49.5 µM 7.83E-5 16 1.09E-4
9 SGTC_1439 4092-1168 3.63 46.0 µM 1.04E-4 19 1.43E-4
10 SGTC_3015 9080845 3.56 49.5 µM 1.38E-4 14 1.88E-4
11 SGTC_1046 2001-0062 3.46 216.0 µM 2.01E-4 32 2.69E-4
12 SGTC_2427 5545055 3.38 42.8 µM 2.78E-4 35 3.66E-4
13 SGTC_591 4299-0174 3.36 154.0 µM 3.01E-4 22 3.95E-4
14 SGTC_1412 3909-8563 3.27 178.0 µM 4.13E-4 26 5.34E-4
15 SGTC_3198 9112019 3.27 49.5 µM 4.20E-4 mitochondrial processes 36 5.44E-4
16 SGTC_381 3461-2219 3.24 42.7 µM 4.56E-4 copper-dependent oxidative stress 43 5.88E-4
17 SGTC_1913 st060213 3.23 96.1 µM 4.75E-4 71 6.11E-4
18 SGTC_1673 st016611 3.16 27.3 µM 6.10E-4 82 7.76E-4
19 SGTC_757 1066-0008 3.14 322.0 µM 6.77E-4 Golgi 55 8.58E-4
20 SGTC_2404 5161160 3.10 200.0 µM 7.62E-4 55 9.60E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.204 6.34E-33 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.196 2.51E-30 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.190 1.14E-28 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.183 1.34E-26 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.180 9.88E-26 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.163 2.47E-21 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.159 1.73E-20 YPL012W RRP12 het Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.157 7.26E-20 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.147 9.57E-18 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.140 3.31E-16 YGL151W NUT1 hom Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
0.135 3.55E-15 YGR049W SCM4 hom Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation
0.135 4.84E-15 YDR234W LYS4 hom Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
0.132 1.52E-14 YGR039W_d YGR039W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
0.132 1.68E-14 YJR061W_p YJR061W_p hom Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication
0.128 8.62E-14 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio