YGL157W / ARI1

NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL157W / ARI1

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:2.92|P-value:7.83E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.15|P-value:2.66E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.12|P-value:3.00E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:6.61|P-value:3.13E-13 ID:SGTC_330|Compound:1488-0319|FD-Score:-4.02|P-value:5.14E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:-2.82|P-value:9.67E-4 ID:SGTC_442|Compound:cape|FD-Score:3.91|P-value:1.10E-5 ID:SGTC_456|Compound:gingerol|FD-Score:3.77|P-value:2.18E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.12|P-value:3.66E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.81|P-value:8.68E-8 ID:SGTC_593|Compound:1203-0218|FD-Score:3.91|P-value:1.12E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.00|P-value:4.76E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.54|P-value:6.17E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.67|P-value:2.74E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.33|P-value:1.53E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.49|P-value:7.60E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.30|P-value:1.75E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:6.50|P-value:7.74E-13 ID:SGTC_1503|Compound:4585-0012|FD-Score:-4.23|P-value:1.74E-6 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.55|P-value:5.92E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.18|P-value:2.78E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-6.49|P-value:5.84E-13 ID:SGTC_1756|Compound:st041558|FD-Score:3.30|P-value:1.76E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.37|P-value:1.04E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.77|P-value:2.10E-5 ID:SGTC_1906|Compound:st060206|FD-Score:3.19|P-value:2.75E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.17|P-value:2.94E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-2.90|P-value:6.96E-4 ID:SGTC_2002|Compound:4023503|FD-Score:5.33|P-value:3.37E-9 ID:SGTC_2007|Compound:4011539|FD-Score:-3.45|P-value:7.45E-5 ID:SGTC_2009|Compound:4012297|FD-Score:4.71|P-value:1.59E-7 ID:SGTC_2010|Compound:4012422|FD-Score:-3.50|P-value:5.86E-5 ID:SGTC_2029|Compound:5175081|FD-Score:2.96|P-value:6.67E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.20|P-value:2.64E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.82|P-value:1.68E-5 ID:SGTC_2103|Compound:5378138|FD-Score:5.15|P-value:1.10E-8 ID:SGTC_2125|Compound:5246583|FD-Score:4.39|P-value:9.53E-7 ID:SGTC_2222|Compound:6885208|FD-Score:2.91|P-value:8.25E-4 ID:SGTC_2284|Compound:7945075|FD-Score:4.03|P-value:6.17E-6 ID:SGTC_2316|Compound:5844804|FD-Score:4.17|P-value:3.02E-6 ID:SGTC_2322|Compound:7413319|FD-Score:5.41|P-value:1.99E-9 ID:SGTC_2329|Compound:6138490|FD-Score:8.57|P-value:5.03E-21 ID:SGTC_2334|Compound:9017922|FD-Score:3.06|P-value:4.54E-4 ID:SGTC_2380|Compound:9035439|FD-Score:4.65|P-value:2.14E-7 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.09|P-value:3.34E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.09|P-value:4.07E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.20|P-value:2.65E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.88|P-value:1.25E-5 ID:SGTC_3021|Compound:9087658|FD-Score:3.19|P-value:2.73E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-2.85|P-value:8.59E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.10|P-value:3.84E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.01|P-value:5.55E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:2.92|P-value:7.83E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.15|P-value:2.66E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.12|P-value:3.00E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:6.61|P-value:3.13E-13 ID:SGTC_330|Compound:1488-0319|FD-Score:-4.02|P-value:5.14E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:-2.82|P-value:9.67E-4 ID:SGTC_442|Compound:cape|FD-Score:3.91|P-value:1.10E-5 ID:SGTC_456|Compound:gingerol|FD-Score:3.77|P-value:2.18E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.12|P-value:3.66E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.81|P-value:8.68E-8 ID:SGTC_593|Compound:1203-0218|FD-Score:3.91|P-value:1.12E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.00|P-value:4.76E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.54|P-value:6.17E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.67|P-value:2.74E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.33|P-value:1.53E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.49|P-value:7.60E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.30|P-value:1.75E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:6.50|P-value:7.74E-13 ID:SGTC_1503|Compound:4585-0012|FD-Score:-4.23|P-value:1.74E-6 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.55|P-value:5.92E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.18|P-value:2.78E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-6.49|P-value:5.84E-13 ID:SGTC_1756|Compound:st041558|FD-Score:3.30|P-value:1.76E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.37|P-value:1.04E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.77|P-value:2.10E-5 ID:SGTC_1906|Compound:st060206|FD-Score:3.19|P-value:2.75E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.17|P-value:2.94E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-2.90|P-value:6.96E-4 ID:SGTC_2002|Compound:4023503|FD-Score:5.33|P-value:3.37E-9 ID:SGTC_2007|Compound:4011539|FD-Score:-3.45|P-value:7.45E-5 ID:SGTC_2009|Compound:4012297|FD-Score:4.71|P-value:1.59E-7 ID:SGTC_2010|Compound:4012422|FD-Score:-3.50|P-value:5.86E-5 ID:SGTC_2029|Compound:5175081|FD-Score:2.96|P-value:6.67E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.20|P-value:2.64E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.82|P-value:1.68E-5 ID:SGTC_2103|Compound:5378138|FD-Score:5.15|P-value:1.10E-8 ID:SGTC_2125|Compound:5246583|FD-Score:4.39|P-value:9.53E-7 ID:SGTC_2222|Compound:6885208|FD-Score:2.91|P-value:8.25E-4 ID:SGTC_2284|Compound:7945075|FD-Score:4.03|P-value:6.17E-6 ID:SGTC_2316|Compound:5844804|FD-Score:4.17|P-value:3.02E-6 ID:SGTC_2322|Compound:7413319|FD-Score:5.41|P-value:1.99E-9 ID:SGTC_2329|Compound:6138490|FD-Score:8.57|P-value:5.03E-21 ID:SGTC_2334|Compound:9017922|FD-Score:3.06|P-value:4.54E-4 ID:SGTC_2380|Compound:9035439|FD-Score:4.65|P-value:2.14E-7 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.09|P-value:3.34E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.09|P-value:4.07E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.20|P-value:2.65E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.88|P-value:1.25E-5 ID:SGTC_3021|Compound:9087658|FD-Score:3.19|P-value:2.73E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-2.85|P-value:8.59E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.10|P-value:3.84E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.01|P-value:5.55E-4

Top fitness defect scores for YGL157W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2329 6138490 8.57 200.0 µM 5.03E-21 4 5.07E-18
2 SGTC_326 k292-0812 6.61 17.5 µM 3.13E-13 1 1.89E-11
3 SGTC_1283 0922-0125 6.50 16.4 µM 7.74E-13 2 4.07E-11
4 SGTC_2322 7413319 5.41 38.2 µM 1.99E-9 ERAD & cell cycle 78 3.10E-8
5 SGTC_2002 4023503 5.33 131.0 µM 3.37E-9 mitochondrial processes 10 4.85E-8
6 SGTC_2103 5378138 5.15 10.0 µM 1.10E-8 4 1.32E-7
7 SGTC_572 0960-0087 4.81 17.7 µM 8.68E-8 10 7.59E-7
8 SGTC_2009 4012297 4.71 12.1 µM 1.59E-7 cell wall signaling 44 1.27E-6
9 SGTC_2380 9035439 4.65 200.0 µM 2.14E-7 endomembrane recycling 8 1.63E-6
10 SGTC_2125 5246583 4.39 200.0 µM 9.53E-7 tubulin folding & SWR complex 34 5.79E-6
11 SGTC_2316 5844804 4.17 197.4 µM 3.02E-6 23 1.54E-5
12 SGTC_2284 7945075 4.03 39.2 µM 6.17E-6 mitochondrial processes 25 2.83E-5
13 SGTC_442 cape 3.91 100.0 µM 1.10E-5 18 4.62E-5
14 SGTC_593 1203-0218 3.91 61.7 µM 1.12E-5 9 4.70E-5
15 SGTC_2924 9010168 3.88 62.8 µM 1.25E-5 cell wall signaling 41 5.16E-5
16 SGTC_2096 5468907 3.82 200.0 µM 1.68E-5 9 6.63E-5
17 SGTC_1898 st060199 3.77 18.6 µM 2.10E-5 22 8.01E-5
18 SGTC_456 gingerol 3.77 170.0 µM 2.18E-5 26 8.27E-5
19 SGTC_1509 1326-1131 3.55 80.0 µM 5.92E-5 20 1.94E-4
20 SGTC_798 1287-0182 3.54 476.0 µM 6.17E-5 33 2.00E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.240 2.76E-45 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.137 2.07E-15 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.123 8.74E-13 YGL130W CEG1 het Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.123 1.03E-12 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.122 1.15E-12 YOR177C MPC54 hom Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
0.105 1.22E-9 YGR042W YGR042W hom Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress
0.100 5.76E-9 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.096 2.30E-8 YLL060C GTT2 hom Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress
0.095 3.05E-8 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.095 4.02E-8 YIL173W VTH1 hom Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting
0.095 4.07E-8 YBL074C AAR2 het Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
0.092 8.06E-8 YML076C WAR1 hom Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
0.087 4.78E-7 YNR019W ARE2 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication
0.087 4.83E-7 YMR158W-B_d YMR158W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C
0.087 5.15E-7 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress