YGL161C / YIP5

Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL161C / YIP5

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:6.69|P-value:4.09E-11 ID:SGTC_49|Compound:0717-0965|FD-Score:3.50|P-value:3.31E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.18|P-value:2.40E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:4.08|P-value:3.71E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:3.23|P-value:8.28E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:6.21|P-value:7.93E-10 ID:SGTC_159|Compound:3970-0959|FD-Score:-4.16|P-value:2.80E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-7.15|P-value:2.09E-12 ID:SGTC_171|Compound:k064-0041|FD-Score:3.28|P-value:7.10E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.24|P-value:8.04E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:4.49|P-value:6.28E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:7.32|P-value:5.74E-13 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.17|P-value:1.02E-9 ID:SGTC_313|Compound:3474-0040|FD-Score:4.69|P-value:2.53E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:6.31|P-value:4.37E-10 ID:SGTC_489|Compound:paxilline|FD-Score:3.50|P-value:3.33E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:4.10|P-value:3.40E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:4.95|P-value:7.41E-7 ID:SGTC_773|Compound:4358-1457|FD-Score:3.69|P-value:1.69E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.01|P-value:4.81E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.38|P-value:5.28E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.22|P-value:8.56E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.64|P-value:1.98E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.51|P-value:3.26E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.15|P-value:2.75E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.23|P-value:1.95E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.97|P-value:5.77E-5 ID:SGTC_1526|Compound:st051518|FD-Score:-3.31|P-value:6.67E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-3.49|P-value:3.65E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.60|P-value:2.31E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.71|P-value:1.54E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.64|P-value:2.18E-8 ID:SGTC_1742|Compound:st038235|FD-Score:3.78|P-value:1.17E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.20|P-value:2.22E-5 ID:SGTC_1750|Compound:st081859|FD-Score:4.25|P-value:1.84E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.69|P-value:2.60E-6 ID:SGTC_1760|Compound:st045453|FD-Score:7.54|P-value:1.23E-13 ID:SGTC_1801|Compound:st050089|FD-Score:5.13|P-value:3.14E-7 ID:SGTC_1803|Compound:st050068|FD-Score:5.36|P-value:9.42E-8 ID:SGTC_1899|Compound:st063254|FD-Score:-3.51|P-value:3.33E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.55|P-value:2.83E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.13|P-value:2.92E-5 ID:SGTC_1942|Compound:st076330|FD-Score:3.35|P-value:5.68E-4 ID:SGTC_2006|Compound:4011487|FD-Score:5.91|P-value:4.67E-9 ID:SGTC_2021|Compound:4019055|FD-Score:6.29|P-value:4.94E-10 ID:SGTC_2036|Compound:5160441|FD-Score:8.40|P-value:1.76E-16 ID:SGTC_2067|Compound:5224629|FD-Score:-3.26|P-value:7.92E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.33|P-value:5.98E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.60|P-value:2.34E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-5.77|P-value:1.15E-8 ID:SGTC_2180|Compound:6301957|FD-Score:3.80|P-value:1.11E-4 ID:SGTC_2219|Compound:9098279|FD-Score:4.35|P-value:1.19E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.20|P-value:8.30E-10 ID:SGTC_2257|Compound:7960413|FD-Score:6.84|P-value:1.57E-11 ID:SGTC_2280|Compound:7785178|FD-Score:3.71|P-value:1.56E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-4.47|P-value:7.42E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.38|P-value:5.00E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.43|P-value:4.30E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.56|P-value:2.82E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.63|P-value:2.11E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.41|P-value:4.75E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.40|P-value:9.41E-6 ID:SGTC_2624|Compound:nerol|FD-Score:-4.48|P-value:7.24E-6 ID:SGTC_2709|Compound:st078560|FD-Score:4.22|P-value:2.07E-5 ID:SGTC_2803|Compound:7707263|FD-Score:3.35|P-value:5.69E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.03|P-value:4.50E-5 ID:SGTC_2904|Compound:7225135|FD-Score:-3.78|P-value:1.24E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.89|P-value:7.73E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.58|P-value:2.53E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:6.69|P-value:4.09E-11 ID:SGTC_49|Compound:0717-0965|FD-Score:3.50|P-value:3.31E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.18|P-value:2.40E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:4.08|P-value:3.71E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:3.23|P-value:8.28E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:6.21|P-value:7.93E-10 ID:SGTC_159|Compound:3970-0959|FD-Score:-4.16|P-value:2.80E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-7.15|P-value:2.09E-12 ID:SGTC_171|Compound:k064-0041|FD-Score:3.28|P-value:7.10E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.24|P-value:8.04E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:4.49|P-value:6.28E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:7.32|P-value:5.74E-13 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.17|P-value:1.02E-9 ID:SGTC_313|Compound:3474-0040|FD-Score:4.69|P-value:2.53E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:6.31|P-value:4.37E-10 ID:SGTC_489|Compound:paxilline|FD-Score:3.50|P-value:3.33E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:4.10|P-value:3.40E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:4.95|P-value:7.41E-7 ID:SGTC_773|Compound:4358-1457|FD-Score:3.69|P-value:1.69E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.01|P-value:4.81E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.38|P-value:5.28E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.22|P-value:8.56E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.64|P-value:1.98E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.51|P-value:3.26E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.15|P-value:2.75E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.23|P-value:1.95E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.97|P-value:5.77E-5 ID:SGTC_1526|Compound:st051518|FD-Score:-3.31|P-value:6.67E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-3.49|P-value:3.65E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.60|P-value:2.31E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.71|P-value:1.54E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.64|P-value:2.18E-8 ID:SGTC_1742|Compound:st038235|FD-Score:3.78|P-value:1.17E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.20|P-value:2.22E-5 ID:SGTC_1750|Compound:st081859|FD-Score:4.25|P-value:1.84E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.69|P-value:2.60E-6 ID:SGTC_1760|Compound:st045453|FD-Score:7.54|P-value:1.23E-13 ID:SGTC_1801|Compound:st050089|FD-Score:5.13|P-value:3.14E-7 ID:SGTC_1803|Compound:st050068|FD-Score:5.36|P-value:9.42E-8 ID:SGTC_1899|Compound:st063254|FD-Score:-3.51|P-value:3.33E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.55|P-value:2.83E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.13|P-value:2.92E-5 ID:SGTC_1942|Compound:st076330|FD-Score:3.35|P-value:5.68E-4 ID:SGTC_2006|Compound:4011487|FD-Score:5.91|P-value:4.67E-9 ID:SGTC_2021|Compound:4019055|FD-Score:6.29|P-value:4.94E-10 ID:SGTC_2036|Compound:5160441|FD-Score:8.40|P-value:1.76E-16 ID:SGTC_2067|Compound:5224629|FD-Score:-3.26|P-value:7.92E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.33|P-value:5.98E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.60|P-value:2.34E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-5.77|P-value:1.15E-8 ID:SGTC_2180|Compound:6301957|FD-Score:3.80|P-value:1.11E-4 ID:SGTC_2219|Compound:9098279|FD-Score:4.35|P-value:1.19E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.20|P-value:8.30E-10 ID:SGTC_2257|Compound:7960413|FD-Score:6.84|P-value:1.57E-11 ID:SGTC_2280|Compound:7785178|FD-Score:3.71|P-value:1.56E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-4.47|P-value:7.42E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.38|P-value:5.00E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.43|P-value:4.30E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.56|P-value:2.82E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.63|P-value:2.11E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.41|P-value:4.75E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.40|P-value:9.41E-6 ID:SGTC_2624|Compound:nerol|FD-Score:-4.48|P-value:7.24E-6 ID:SGTC_2709|Compound:st078560|FD-Score:4.22|P-value:2.07E-5 ID:SGTC_2803|Compound:7707263|FD-Score:3.35|P-value:5.69E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.03|P-value:4.50E-5 ID:SGTC_2904|Compound:7225135|FD-Score:-3.78|P-value:1.24E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.89|P-value:7.73E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.58|P-value:2.53E-4

Top fitness defect scores for YGL161C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2036 5160441 8.40 105.0 µM 1.76E-16 NEO1 27 2.32E-17
2 SGTC_1760 st045453 7.54 10.4 µM 1.23E-13 NEO1-PIK1 62 2.40E-14
3 SGTC_181 1447-1644 7.32 8.1 µM 5.74E-13 endomembrane recycling 9 1.23E-13
4 SGTC_2257 7960413 6.84 200.0 µM 1.57E-11 NEO1-PIK1 8 4.08E-12
5 SGTC_15 0266-0086 6.69 27.1 µM 4.09E-11 endomembrane recycling 12 1.13E-11
6 SGTC_439 amiodarone 6.31 34.4 µM 4.37E-10 NEO1-PIK1 44 1.39E-10
7 SGTC_2021 4019055 6.29 173.0 µM 4.94E-10 endomembrane recycling 34 1.58E-10
8 SGTC_146 3448-8650 6.21 53.1 µM 7.93E-10 NEO1-PIK1 51 2.61E-10
9 SGTC_2249 haloperidol 6.20 116.4 µM 8.30E-10 ergosterol depletion effects on membrane 41 2.74E-10
10 SGTC_221 trifluoperazine 6.17 10.3 µM 1.02E-9 NEO1-PIK1 119 3.39E-10
11 SGTC_2006 4011487 5.91 200.0 µM 4.67E-9 endomembrane recycling 45 1.71E-9
12 SGTC_1712 st032288 5.64 53.4 µM 2.18E-8 calcium & mitochondrial duress 87 8.73E-9
13 SGTC_1803 st050068 5.36 52.4 µM 9.42E-8 NEO1-PIK1 104 4.11E-8
14 SGTC_1801 st050089 5.13 28.4 µM 3.14E-7 NEO1-PIK1 72 1.47E-7
15 SGTC_649 1123-0311 4.95 367.0 µM 7.41E-7 endomembrane recycling 40 3.64E-7
16 SGTC_313 3474-0040 4.69 5.0 µM 2.53E-6 NEO1-PIK1 45 1.33E-6
17 SGTC_1754 st042065 4.69 16.1 µM 2.60E-6 NEO1-PIK1 143 1.37E-6
18 SGTC_178 4092-0806 4.49 87.5 µM 6.28E-6 ergosterol depletion effects on membrane 70 3.50E-6
19 SGTC_2617 dihydrotanshinone i 4.40 20.8 µM 9.41E-6 copper-dependent oxidative stress 24 5.36E-6
20 SGTC_2219 9098279 4.35 200.0 µM 1.19E-5 3 6.87E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.520 1.58E-231 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.464 5.08E-179 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.450 4.80E-167 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
0.418 3.69E-142 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.399 3.33E-128 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.380 9.79E-116 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.344 1.65E-93 YGL198W YIP4 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.339 7.90E-91 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.331 1.83E-86 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.329 3.28E-85 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.328 4.64E-85 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.319 4.93E-80 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.316 1.46E-78 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.313 5.59E-77 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.309 1.99E-75 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism