HIPHOP chemogenomics database

YGL170C / SPO74

Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation

Zygosity: Homozygous strain

fixedexpanded
Profile for YGL170C / SPO74

Click on Significant Values for Screen Details

Top fitness defect scores for YGL170C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1243	0416-0003	6.62	5.7 µM	3.52E-11	PDR1	4	1.78E-11
2	SGTC_1779	st039427	4.92	55.0 µM	6.31E-7		8	4.31E-7
3	SGTC_1087	pterostilbene	4.87	9.1 µM	8.11E-7		8	5.58E-7
4	SGTC_1239	0337-0584	4.77	35.4 µM	1.33E-6	unfolded protein response	31	9.29E-7
5	SGTC_757	1066-0008	4.63	322.0 µM	2.53E-6	Golgi	11	1.81E-6
6	SGTC_1241	0364-0022	4.51	50.8 µM	4.38E-6	ERG2	21	3.18E-6
7	SGTC_521	r062-0005	4.41	13.8 µM	7.14E-6		10	5.25E-6
8	SGTC_1350	1495-0454	4.40	146.0 µM	7.41E-6		16	5.46E-6
9	SGTC_1783	st039459	4.32	87.5 µM	1.03E-5	Golgi	18	7.66E-6
10	SGTC_809	3998-0021	4.15	90.0 µM	2.15E-5	RNA processing & uracil transport	11	1.63E-5
11	SGTC_1452	4194-0072	3.97	190.0 µM	4.66E-5		12	3.62E-5
12	SGTC_2849	9019321	3.87	13.0 µM	7.02E-5		32	5.53E-5
13	SGTC_1121	fusaric acid	3.84	630.5 nM	7.87E-5		38	6.22E-5
14	SGTC_1790	st045711	3.83	43.5 µM	8.06E-5		15	6.37E-5
15	SGTC_1777	st045864	3.77	34.8 µM	1.04E-4		12	8.25E-5
16	SGTC_2997	9067075	3.74	71.4 µM	1.14E-4	unfolded protein response	58	9.13E-5
17	SGTC_741	4582-0002	3.58	126.0 µM	2.12E-4		17	1.73E-4
18	SGTC_1071	trifluoperazine	3.58	6.3 µM	2.14E-4		38	1.74E-4
19	SGTC_3046	9092212	3.55	49.5 µM	2.39E-4		13	1.95E-4
20	SGTC_2877	9040724	3.55	71.4 µM	2.40E-4		18	1.96E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.153	4.72E-19	YFL032W_d	YFL032W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.148	5.88E-18	YML130C	ERO1	het	Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.123	1.11E-12	YDR095C_d	YDR095C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.110	1.61E-10	YLL062C	MHT1	hom	S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.108	3.85E-10	YGR205W	TDA10	hom	ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele
0.103	1.96E-9	YGR234W	YHB1	hom	Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.099	1.00E-8	YML052W	SUR7	hom	Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.098	1.25E-8	YHR079C	IRE1	hom	Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.098	1.40E-8	YDR315C	IPK1	hom	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.093	6.16E-8	YLR132C	USB1	het	Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.092	8.31E-8	YLR241W_p	YLR241W_p	hom	Putative protein of unknown function, may be involved in detoxification
0.087	4.27E-7	YGL202W	ARO8	hom	Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
0.086	5.28E-7	YGR099W	TEL2	het	Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1
0.083	1.63E-6	YDR181C	SAS4	hom	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.081	2.71E-6	YKL221W	MCH2	hom	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport