HIPHOP chemogenomics database

YGL178W / MPT5

mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity

Zygosity: Homozygous strain

fixedexpanded
Profile for YGL178W / MPT5

Click on Significant Values for Screen Details

Top fitness defect scores for YGL178W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2582	agaric acid	13.10	100.0 µM	1.11E-47	redox potentiating	27	2.62E-39
2	SGTC_2707	st078556	6.35	66.6 µM	1.08E-12		1	1.10E-10
3	SGTC_58	0957-0393	5.83	9.0 µM	5.50E-11	cell wall	220	2.77E-9
4	SGTC_2927	9011802	5.22	47.9 µM	3.89E-9		9	9.13E-8
5	SGTC_738	1315-0003	5.01	72.4 µM	1.45E-8		8	2.69E-7
6	SGTC_2802	7925815	4.99	54.5 µM	1.66E-8		17	3.01E-7
7	SGTC_3010	9080089	4.81	71.4 µM	5.18E-8		3	7.66E-7
8	SGTC_453	enantio-paf c16	4.43	10.0 µM	4.72E-7		112	4.72E-6
9	SGTC_2083	5306046	4.33	65.9 µM	8.33E-7		18	7.53E-6
10	SGTC_1004	4084-0029	4.27	199.0 µM	1.15E-6		10	9.79E-6
11	SGTC_2141	5621638	4.26	7.7 µM	1.19E-6	tubulin folding & SWR complex	30	1.01E-5
12	SGTC_2584	androsterone	4.20	48.7 µM	1.65E-6	cell wall	116	1.32E-5
13	SGTC_3013	9080133	4.17	71.4 µM	1.94E-6		17	1.51E-5
14	SGTC_894	0960-0238	4.17	55.9 µM	1.96E-6		7	1.52E-5
15	SGTC_2640	pentamidine	3.99	10.4 µM	5.03E-6	mitochondrial processes	33	3.31E-5
16	SGTC_2327	6189656	3.96	200.0 µM	5.90E-6		24	3.78E-5
17	SGTC_1167	k781-0610	3.61	148.0 µM	3.28E-5	RNA processing & uracil transport	39	1.55E-4
18	SGTC_1635	st007035	3.60	42.4 µM	3.46E-5		240	1.62E-4
19	SGTC_3011	9081274	3.56	71.4 µM	4.09E-5		28	1.86E-4
20	SGTC_2583	asiatic acid	3.53	100.0 µM	4.74E-5		50	2.10E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.373	2.58E-111	YNL106C	INP52	hom	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.367	1.02E-107	YML103C	NUP188	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.318	1.30E-79	YML101C-A_d	YML101C-A_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.314	1.29E-77	YEL007W	MIT1	hom	Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.305	2.60E-73	YOR049C	RSB1	hom	Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.295	3.03E-68	YOR050C_d	YOR050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.294	7.25E-68	YMR109W	MYO5	hom	One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.291	1.84E-66	YML102W	CAC2	hom	Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.286	2.22E-64	YNL027W	CRZ1	hom	Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.278	2.52E-60	YNL215W	IES2	hom	Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.269	8.36E-57	YBR134W_d	YBR134W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.253	3.85E-50	YOL003C	PFA4	hom	Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.248	4.44E-48	YIL111W	COX5B	hom	Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.246	2.72E-47	YMR214W	SCJ1	hom	One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.245	3.52E-47	YML052W	SUR7	hom	Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants