YGL191W / COX13

Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL191W / COX13

Click on Significant Values for Screen Details ID:SGTC_134|Compound:0269-0018|FD-Score:4.51|P-value:8.29E-7 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.51|P-value:1.24E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:3.97|P-value:1.22E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:9.19|P-value:1.22E-22 ID:SGTC_264|Compound:promethazine|FD-Score:-3.15|P-value:5.12E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.02|P-value:6.55E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:2.94|P-value:8.52E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.47|P-value:1.46E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.22|P-value:3.04E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.89|P-value:1.77E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.24|P-value:2.81E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.01|P-value:6.69E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.32|P-value:2.09E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.10|P-value:6.04E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:2.93|P-value:8.83E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.16|P-value:5.06E-6 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.03|P-value:9.09E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:2.95|P-value:8.33E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.88|P-value:1.89E-5 ID:SGTC_1635|Compound:st007035|FD-Score:16.80|P-value:5.26E-71 ID:SGTC_1728|Compound:st035614|FD-Score:3.50|P-value:1.00E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.66|P-value:4.93E-5 ID:SGTC_1826|Compound:st055655|FD-Score:3.37|P-value:1.71E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.05|P-value:4.17E-8 ID:SGTC_1902|Compound:st060212|FD-Score:-3.02|P-value:8.10E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.35|P-value:1.84E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-4.26|P-value:4.21E-6 ID:SGTC_2041|Compound:5107442|FD-Score:3.05|P-value:5.72E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-2.98|P-value:9.30E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.45|P-value:1.22E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.11|P-value:5.81E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.10|P-value:4.90E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.39|P-value:1.52E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.34|P-value:1.89E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.74|P-value:2.49E-7 ID:SGTC_2848|Compound:9016370|FD-Score:3.20|P-value:3.27E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.25|P-value:2.69E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.07|P-value:5.38E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.94|P-value:1.88E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.99|P-value:1.13E-5 ID:SGTC_3235|Compound:9132602|FD-Score:-3.03|P-value:7.88E-4 ID:SGTC_3274|Compound:9138298|FD-Score:2.92|P-value:9.17E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:4.51|P-value:8.29E-7 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.51|P-value:1.24E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:3.97|P-value:1.22E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:9.19|P-value:1.22E-22 ID:SGTC_264|Compound:promethazine|FD-Score:-3.15|P-value:5.12E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.02|P-value:6.55E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:2.94|P-value:8.52E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.47|P-value:1.46E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.22|P-value:3.04E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.89|P-value:1.77E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.24|P-value:2.81E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.01|P-value:6.69E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.32|P-value:2.09E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.10|P-value:6.04E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:2.93|P-value:8.83E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.16|P-value:5.06E-6 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.03|P-value:9.09E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:2.95|P-value:8.33E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.88|P-value:1.89E-5 ID:SGTC_1635|Compound:st007035|FD-Score:16.80|P-value:5.26E-71 ID:SGTC_1728|Compound:st035614|FD-Score:3.50|P-value:1.00E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.66|P-value:4.93E-5 ID:SGTC_1826|Compound:st055655|FD-Score:3.37|P-value:1.71E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.05|P-value:4.17E-8 ID:SGTC_1902|Compound:st060212|FD-Score:-3.02|P-value:8.10E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.35|P-value:1.84E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-4.26|P-value:4.21E-6 ID:SGTC_2041|Compound:5107442|FD-Score:3.05|P-value:5.72E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-2.98|P-value:9.30E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.45|P-value:1.22E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.11|P-value:5.81E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.10|P-value:4.90E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.39|P-value:1.52E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.34|P-value:1.89E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.74|P-value:2.49E-7 ID:SGTC_2848|Compound:9016370|FD-Score:3.20|P-value:3.27E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.25|P-value:2.69E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.07|P-value:5.38E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.94|P-value:1.88E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.99|P-value:1.13E-5 ID:SGTC_3235|Compound:9132602|FD-Score:-3.03|P-value:7.88E-4 ID:SGTC_3274|Compound:9138298|FD-Score:2.92|P-value:9.17E-4

Top fitness defect scores for YGL191W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 16.80 42.4 µM 5.26E-71 28 6.86E-64
2 SGTC_236 1509-0011 9.19 5.3 µM 1.22E-22 210 1.94E-20
3 SGTC_1844 rapamycin 5.05 4.0 nM 4.17E-8 114 2.18E-7
4 SGTC_2827 7993847 4.74 71.4 µM 2.49E-7 11 1.08E-6
5 SGTC_134 0269-0018 4.51 6.9 µM 8.29E-7 111 3.19E-6
6 SGTC_1368 1852-0141 4.16 284.0 µM 5.06E-6 ERG2 35 1.62E-5
7 SGTC_1380 2291-0730 4.03 164.0 µM 9.09E-6 24 2.74E-5
8 SGTC_3197 9113331 3.99 49.5 µM 1.13E-5 31 3.32E-5
9 SGTC_211 3455-0679 3.97 143.5 µM 1.22E-5 20 3.58E-5
10 SGTC_773 4358-1457 3.89 44.6 µM 1.77E-5 48 4.99E-5
11 SGTC_1426 4048-4480 3.88 71.7 µM 1.89E-5 60S ribosome export 17 5.28E-5
12 SGTC_1732 st034308 3.66 51.8 µM 4.93E-5 31 1.25E-4
13 SGTC_1728 st035614 3.50 33.8 µM 1.00E-4 77 2.36E-4
14 SGTC_2285 7945142 3.45 200.0 µM 1.22E-4 35 2.83E-4
15 SGTC_2692 st077426 3.39 47.7 µM 1.52E-4 36 3.43E-4
16 SGTC_1826 st055655 3.37 41.6 µM 1.71E-4 ERG2 60 3.81E-4
17 SGTC_2013 4024628 3.35 200.0 µM 1.84E-4 69 4.09E-4
18 SGTC_2697 mebhydrolin 3.34 72.4 µM 1.89E-4 NEO1 95 4.18E-4
19 SGTC_1008 4106-0037 3.32 6.0 µM 2.09E-4 PDR1 36 4.57E-4
20 SGTC_2931 9014674 3.25 55.7 µM 2.69E-4 52 5.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.607 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.585 7.04E-308 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.567 5.51E-284 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.557 2.92E-272 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.537 2.96E-250 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.533 2.75E-245 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.520 1.65E-231 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.510 1.09E-221 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.501 1.95E-212 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.497 1.56E-208 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.496 1.83E-207 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.490 8.40E-202 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.485 3.55E-197 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.480 5.66E-193 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.480 1.35E-192 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase