YGL199C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL199C / YGL199C

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.62|P-value:2.34E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:8.52|P-value:6.48E-22 ID:SGTC_57|Compound:miconazole|FD-Score:7.38|P-value:6.53E-17 ID:SGTC_146|Compound:3448-8650|FD-Score:3.71|P-value:1.57E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.13|P-value:2.45E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.38|P-value:4.34E-7 ID:SGTC_197|Compound:4544-0043|FD-Score:3.59|P-value:2.79E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:8.68|P-value:1.11E-22 ID:SGTC_260|Compound:nsc-65238|FD-Score:2.76|P-value:9.61E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.45|P-value:2.88E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:3.39|P-value:6.78E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:9.55|P-value:4.59E-27 ID:SGTC_439|Compound:amiodarone|FD-Score:7.77|P-value:1.39E-18 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.56|P-value:1.51E-7 ID:SGTC_460|Compound:trequinsin|FD-Score:-3.06|P-value:3.23E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.97|P-value:4.08E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:7.23|P-value:2.64E-16 ID:SGTC_752|Compound:1896-0090|FD-Score:-3.74|P-value:1.49E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:4.68|P-value:7.30E-8 ID:SGTC_910|Compound:3454-3003|FD-Score:3.04|P-value:3.15E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.68|P-value:1.76E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:2.76|P-value:9.46E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-2.78|P-value:9.59E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.22|P-value:1.49E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.04|P-value:3.54E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.60|P-value:2.56E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:-2.87|P-value:6.83E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.89|P-value:6.10E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.37|P-value:7.56E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:2.99|P-value:3.87E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-3.25|P-value:1.44E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-3.07|P-value:3.12E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.46|P-value:4.98E-5 ID:SGTC_1672|Compound:st016598|FD-Score:9.76|P-value:3.78E-28 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.59|P-value:1.30E-7 ID:SGTC_1750|Compound:st081859|FD-Score:3.08|P-value:2.65E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.77|P-value:1.13E-5 ID:SGTC_1760|Compound:st045453|FD-Score:6.59|P-value:7.42E-14 ID:SGTC_1797|Compound:st048695|FD-Score:4.63|P-value:9.80E-8 ID:SGTC_1803|Compound:st050068|FD-Score:3.86|P-value:7.27E-6 ID:SGTC_1923|Compound:st058458|FD-Score:3.69|P-value:1.67E-5 ID:SGTC_1933|Compound:st074711|FD-Score:2.75|P-value:9.85E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-2.94|P-value:5.25E-4 ID:SGTC_2006|Compound:4011487|FD-Score:11.60|P-value:9.50E-39 ID:SGTC_2021|Compound:4019055|FD-Score:3.01|P-value:3.56E-4 ID:SGTC_2036|Compound:5160441|FD-Score:6.72|P-value:2.31E-14 ID:SGTC_2045|Compound:5106652|FD-Score:2.99|P-value:3.89E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.53|P-value:3.60E-5 ID:SGTC_2257|Compound:7960413|FD-Score:5.63|P-value:1.33E-10 ID:SGTC_2298|Compound:7976326|FD-Score:2.96|P-value:4.37E-4 ID:SGTC_2374|Compound:9071832|FD-Score:5.23|P-value:2.11E-9 ID:SGTC_2439|Compound:5492030|FD-Score:2.98|P-value:3.94E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.67|P-value:1.88E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.32|P-value:9.56E-5 ID:SGTC_2780|Compound:5215298|FD-Score:3.89|P-value:6.35E-6 ID:SGTC_2790|Compound:5423970|FD-Score:7.14|P-value:5.76E-16 ID:SGTC_2794|Compound:7785382|FD-Score:4.75|P-value:4.80E-8 ID:SGTC_2799|Compound:7812892|FD-Score:3.11|P-value:2.36E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.12|P-value:2.55E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.98|P-value:3.98E-6 ID:SGTC_3005|Compound:9076496|FD-Score:-2.85|P-value:7.47E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.89|P-value:6.19E-6 ID:SGTC_3018|Compound:9082602|FD-Score:2.99|P-value:3.90E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.12|P-value:2.21E-4 ID:SGTC_3308|Compound:9128332|FD-Score:2.97|P-value:4.15E-4 ID:SGTC_3327|Compound:9140648|FD-Score:4.04|P-value:2.90E-6 ID:SGTC_3328|Compound:9140624|FD-Score:3.16|P-value:1.90E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:3.62|P-value:2.34E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:8.52|P-value:6.48E-22 ID:SGTC_57|Compound:miconazole|FD-Score:7.38|P-value:6.53E-17 ID:SGTC_146|Compound:3448-8650|FD-Score:3.71|P-value:1.57E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.13|P-value:2.45E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.38|P-value:4.34E-7 ID:SGTC_197|Compound:4544-0043|FD-Score:3.59|P-value:2.79E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:8.68|P-value:1.11E-22 ID:SGTC_260|Compound:nsc-65238|FD-Score:2.76|P-value:9.61E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.45|P-value:2.88E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:3.39|P-value:6.78E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:9.55|P-value:4.59E-27 ID:SGTC_439|Compound:amiodarone|FD-Score:7.77|P-value:1.39E-18 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.56|P-value:1.51E-7 ID:SGTC_460|Compound:trequinsin|FD-Score:-3.06|P-value:3.23E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.97|P-value:4.08E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:7.23|P-value:2.64E-16 ID:SGTC_752|Compound:1896-0090|FD-Score:-3.74|P-value:1.49E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:4.68|P-value:7.30E-8 ID:SGTC_910|Compound:3454-3003|FD-Score:3.04|P-value:3.15E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.68|P-value:1.76E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:2.76|P-value:9.46E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-2.78|P-value:9.59E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.22|P-value:1.49E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.04|P-value:3.54E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.60|P-value:2.56E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:-2.87|P-value:6.83E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.89|P-value:6.10E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.37|P-value:7.56E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:2.99|P-value:3.87E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-3.25|P-value:1.44E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-3.07|P-value:3.12E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.46|P-value:4.98E-5 ID:SGTC_1672|Compound:st016598|FD-Score:9.76|P-value:3.78E-28 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.59|P-value:1.30E-7 ID:SGTC_1750|Compound:st081859|FD-Score:3.08|P-value:2.65E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.77|P-value:1.13E-5 ID:SGTC_1760|Compound:st045453|FD-Score:6.59|P-value:7.42E-14 ID:SGTC_1797|Compound:st048695|FD-Score:4.63|P-value:9.80E-8 ID:SGTC_1803|Compound:st050068|FD-Score:3.86|P-value:7.27E-6 ID:SGTC_1923|Compound:st058458|FD-Score:3.69|P-value:1.67E-5 ID:SGTC_1933|Compound:st074711|FD-Score:2.75|P-value:9.85E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-2.94|P-value:5.25E-4 ID:SGTC_2006|Compound:4011487|FD-Score:11.60|P-value:9.50E-39 ID:SGTC_2021|Compound:4019055|FD-Score:3.01|P-value:3.56E-4 ID:SGTC_2036|Compound:5160441|FD-Score:6.72|P-value:2.31E-14 ID:SGTC_2045|Compound:5106652|FD-Score:2.99|P-value:3.89E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.53|P-value:3.60E-5 ID:SGTC_2257|Compound:7960413|FD-Score:5.63|P-value:1.33E-10 ID:SGTC_2298|Compound:7976326|FD-Score:2.96|P-value:4.37E-4 ID:SGTC_2374|Compound:9071832|FD-Score:5.23|P-value:2.11E-9 ID:SGTC_2439|Compound:5492030|FD-Score:2.98|P-value:3.94E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.67|P-value:1.88E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.32|P-value:9.56E-5 ID:SGTC_2780|Compound:5215298|FD-Score:3.89|P-value:6.35E-6 ID:SGTC_2790|Compound:5423970|FD-Score:7.14|P-value:5.76E-16 ID:SGTC_2794|Compound:7785382|FD-Score:4.75|P-value:4.80E-8 ID:SGTC_2799|Compound:7812892|FD-Score:3.11|P-value:2.36E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.12|P-value:2.55E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.98|P-value:3.98E-6 ID:SGTC_3005|Compound:9076496|FD-Score:-2.85|P-value:7.47E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.89|P-value:6.19E-6 ID:SGTC_3018|Compound:9082602|FD-Score:2.99|P-value:3.90E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.12|P-value:2.21E-4 ID:SGTC_3308|Compound:9128332|FD-Score:2.97|P-value:4.15E-4 ID:SGTC_3327|Compound:9140648|FD-Score:4.04|P-value:2.90E-6 ID:SGTC_3328|Compound:9140624|FD-Score:3.16|P-value:1.90E-4

Top fitness defect scores for YGL199C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2006 4011487 11.60 200.0 µM 9.50E-39 endomembrane recycling 8 3.03E-31
2 SGTC_1672 st016598 9.76 6.5 µM 3.78E-28 endomembrane recycling 9 8.72E-23
3 SGTC_313 3474-0040 9.55 5.0 µM 4.59E-27 NEO1-PIK1 3 6.40E-22
4 SGTC_221 trifluoperazine 8.68 10.3 µM 1.11E-22 NEO1-PIK1 75 2.02E-18
5 SGTC_15 0266-0086 8.52 27.1 µM 6.48E-22 endomembrane recycling 8 8.27E-18
6 SGTC_439 amiodarone 7.77 34.4 µM 1.39E-18 NEO1-PIK1 25 3.78E-15
7 SGTC_57 miconazole 7.38 162.5 nM 6.53E-17 ergosterol depletion effects on membrane 6 8.20E-14
8 SGTC_649 1123-0311 7.23 367.0 µM 2.64E-16 endomembrane recycling 18 2.50E-13
9 SGTC_2790 5423970 7.14 71.4 µM 5.76E-16 endomembrane recycling 17 4.67E-13
10 SGTC_2036 5160441 6.72 105.0 µM 2.31E-14 NEO1 37 8.94E-12
11 SGTC_1760 st045453 6.59 10.4 µM 7.42E-14 NEO1-PIK1 72 2.27E-11
12 SGTC_2257 7960413 5.63 200.0 µM 1.33E-10 NEO1-PIK1 18 9.06E-9
13 SGTC_2374 9071832 5.23 200.0 µM 2.11E-9 endomembrane recycling 9 8.30E-8
14 SGTC_2794 7785382 4.75 27.3 µM 4.80E-8 11 1.02E-6
15 SGTC_788 1182-0090 4.68 188.0 µM 7.30E-8 endomembrane recycling 59 1.42E-6
16 SGTC_1797 st048695 4.63 56.8 µM 9.80E-8 NEO1 59 1.80E-6
17 SGTC_1679 4130-1276 4.59 6.7 µM 1.30E-7 Golgi 47 2.25E-6
18 SGTC_453 enantio-paf c16 4.56 10.0 µM 1.51E-7 107 2.54E-6
19 SGTC_270 tamoxifen 4.45 5.5 µM 2.88E-7 NEO1 19 4.27E-6
20 SGTC_181 1447-1644 4.38 8.1 µM 4.34E-7 endomembrane recycling 24 5.93E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.603 0 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.554 1.02E-269 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.508 9.01E-220 YGL198W YIP4 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.450 4.26E-166 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.450 4.80E-167 YGL161C YIP5 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.439 1.60E-157 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.430 4.93E-151 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.415 4.91E-140 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.408 5.59E-135 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.407 2.63E-134 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.403 8.25E-131 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.402 3.18E-130 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.395 8.41E-126 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.359 1.05E-102 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.355 1.79E-100 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication