HIPHOP chemogenomics database

YGL203C / KEX1

Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins

Zygosity: Homozygous strain

fixedexpanded
Profile for YGL203C / KEX1

Click on Significant Values for Screen Details

Top fitness defect scores for YGL203C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2021	4019055	9.83	173.0 µM	4.37E-24	endomembrane recycling	11	4.00E-23
2	SGTC_1712	st032288	9.09	53.4 µM	7.36E-21	calcium & mitochondrial duress	32	4.85E-20
3	SGTC_351	caspofungin	6.82	25.0 nM	1.61E-12	cell wall	30	4.57E-12
4	SGTC_528	3492-0019	6.46	172.0 µM	2.01E-11	calcium & mitochondrial duress	108	5.12E-11
5	SGTC_2419	paclitaxel	6.18	166.5 µM	1.34E-10		4	3.16E-10
6	SGTC_1228	0124-0032	5.81	52.5 µM	1.50E-9		2	3.18E-9
7	SGTC_1512	0259-0544	5.70	12.2 µM	2.85E-9		1	5.88E-9
8	SGTC_1431	4049-0260	5.17	9.1 µM	6.63E-8		2	1.20E-7
9	SGTC_320	4092-0846	4.85	5.3 µM	3.62E-7	ergosterol depletion effects on membrane	27	6.07E-7
10	SGTC_1019	4262-0212	4.82	3.4 µM	4.41E-7	ergosterol depletion effects on membrane	35	7.35E-7
11	SGTC_1563	conessine	4.74	56.1 µM	6.57E-7		6	1.08E-6
12	SGTC_1572	epiandrosterone	4.61	68.9 µM	1.27E-6		20	2.02E-6
13	SGTC_447	ml7	4.14	120.0 µM	1.18E-5	NEO1-PIK1	25	1.71E-5
14	SGTC_1439	4092-1168	4.06	46.0 µM	1.74E-5		8	2.49E-5
15	SGTC_1803	st050068	3.97	52.4 µM	2.56E-5	NEO1-PIK1	178	3.61E-5
16	SGTC_1687	st020778	3.87	55.4 µM	3.96E-5		179	5.47E-5
17	SGTC_346	4513-0042	3.71	7.2 µM	7.83E-5	azole & statin	50	1.05E-4
18	SGTC_1412	3909-8563	3.69	178.0 µM	8.28E-5		13	1.11E-4
19	SGTC_1376	2910-0861	3.34	41.3 µM	3.35E-4		40	4.25E-4
20	SGTC_1801	st050089	3.31	28.4 µM	3.74E-4	NEO1-PIK1	165	4.73E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.377	1.77E-113	YKL051W	SFK1	hom	Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.359	1.41E-102	YDL019C	OSH2	hom	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.338	1.23E-90	YOR086C	TCB1	hom	Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.328	9.95E-85	YDR475C	JIP4	hom	Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.316	1.99E-78	YGL035C	MIG1	hom	Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.290	3.63E-66	YCL021W-A_p	YCL021W-A_p	hom	Putative protein of unknown function
0.288	3.50E-65	YDR467C_d	YDR467C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.288	4.01E-65	YIL170W	HXT12	hom	Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.269	7.35E-57	YPR091C	NVJ2	hom	Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.257	8.03E-52	YER120W	SCS2	hom	Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication
0.257	1.16E-51	YDR491C_d	YDR491C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.247	9.43E-48	YDR357C_p	CNL1_p	hom	Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.243	3.83E-46	YPL145C	KES1	hom	One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.242	4.47E-46	YDR492W	IZH1	hom	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.231	5.65E-42	YGL151W	NUT1	hom	Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription