YGL210W / YPT32

Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL210W / YPT32

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-2.93|P-value:4.61E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-2.96|P-value:4.07E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.51|P-value:3.65E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:3.25|P-value:1.05E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-2.90|P-value:5.16E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:2.82|P-value:6.35E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.04|P-value:2.57E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.04|P-value:2.57E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.54|P-value:2.66E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.24|P-value:1.27E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-2.87|P-value:5.95E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:2.72|P-value:9.52E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.48|P-value:3.69E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:2.72|P-value:9.67E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-3.04|P-value:2.99E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.08|P-value:2.21E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.76|P-value:2.90E-8 ID:SGTC_1630|Compound:st005209|FD-Score:2.75|P-value:8.56E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.17|P-value:1.69E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.11|P-value:2.23E-4 ID:SGTC_1795|Compound:st049545|FD-Score:2.94|P-value:4.04E-4 ID:SGTC_1806|Compound:st050005|FD-Score:-2.79|P-value:8.23E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-3.08|P-value:2.47E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.49|P-value:1.61E-7 ID:SGTC_2105|Compound:5350118|FD-Score:2.99|P-value:3.26E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.38|P-value:5.80E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.55|P-value:2.59E-5 ID:SGTC_2349|Compound:9023730|FD-Score:2.81|P-value:6.77E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.74|P-value:9.95E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.04|P-value:2.67E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:6.82|P-value:4.10E-15 ID:SGTC_2811|Compound:7967822|FD-Score:2.75|P-value:8.42E-4 ID:SGTC_2870|Compound:9038528|FD-Score:-2.86|P-value:6.23E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-2.79|P-value:8.19E-4 ID:SGTC_3195|Compound:9113082|FD-Score:4.39|P-value:2.86E-7 ID:SGTC_3208|Compound:9114115|FD-Score:4.92|P-value:1.05E-8 ID:SGTC_3209|Compound:9113616|FD-Score:3.47|P-value:3.86E-5 ID:SGTC_3217|Compound:9129673|FD-Score:4.18|P-value:9.33E-7 ID:SGTC_3306|Compound:9127676|FD-Score:2.79|P-value:7.30E-4 ID:SGTC_3308|Compound:9128332|FD-Score:4.54|P-value:1.15E-7 ID:SGTC_72|Compound:0744-0168|FD-Score:-2.93|P-value:4.61E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-2.96|P-value:4.07E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.51|P-value:3.65E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:3.25|P-value:1.05E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-2.90|P-value:5.16E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:2.82|P-value:6.35E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.04|P-value:2.57E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.04|P-value:2.57E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.54|P-value:2.66E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.24|P-value:1.27E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-2.87|P-value:5.95E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:2.72|P-value:9.52E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.48|P-value:3.69E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:2.72|P-value:9.67E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-3.04|P-value:2.99E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.08|P-value:2.21E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.76|P-value:2.90E-8 ID:SGTC_1630|Compound:st005209|FD-Score:2.75|P-value:8.56E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.17|P-value:1.69E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.11|P-value:2.23E-4 ID:SGTC_1795|Compound:st049545|FD-Score:2.94|P-value:4.04E-4 ID:SGTC_1806|Compound:st050005|FD-Score:-2.79|P-value:8.23E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-3.08|P-value:2.47E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.49|P-value:1.61E-7 ID:SGTC_2105|Compound:5350118|FD-Score:2.99|P-value:3.26E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.38|P-value:5.80E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.55|P-value:2.59E-5 ID:SGTC_2349|Compound:9023730|FD-Score:2.81|P-value:6.77E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.74|P-value:9.95E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.04|P-value:2.67E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:6.82|P-value:4.10E-15 ID:SGTC_2811|Compound:7967822|FD-Score:2.75|P-value:8.42E-4 ID:SGTC_2870|Compound:9038528|FD-Score:-2.86|P-value:6.23E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-2.79|P-value:8.19E-4 ID:SGTC_3195|Compound:9113082|FD-Score:4.39|P-value:2.86E-7 ID:SGTC_3208|Compound:9114115|FD-Score:4.92|P-value:1.05E-8 ID:SGTC_3209|Compound:9113616|FD-Score:3.47|P-value:3.86E-5 ID:SGTC_3217|Compound:9129673|FD-Score:4.18|P-value:9.33E-7 ID:SGTC_3306|Compound:9127676|FD-Score:2.79|P-value:7.30E-4 ID:SGTC_3308|Compound:9128332|FD-Score:4.54|P-value:1.15E-7

Top fitness defect scores for YGL210W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2756 carbadox 6.82 75.1 µM 4.10E-15 13 4.49E-12
2 SGTC_3208 9114115 4.92 49.5 µM 1.05E-8 17 4.34E-7
3 SGTC_1625 st003711 4.76 30.1 µM 2.90E-8 calcium & mitochondrial duress 20 9.59E-7
4 SGTC_3308 9128332 4.54 17.6 µM 1.15E-7 plasma membrane duress 57 2.79E-6
5 SGTC_2002 4023503 4.49 131.0 µM 1.61E-7 mitochondrial processes 20 3.64E-6
6 SGTC_3195 9113082 4.39 49.5 µM 2.86E-7 10 5.71E-6
7 SGTC_3217 9129673 4.18 49.5 µM 9.33E-7 30 1.44E-5
8 SGTC_2303 7774051 3.55 200.0 µM 2.59E-5 35 1.93E-4
9 SGTC_759 3486-0358 3.54 89.3 µM 2.66E-5 30 1.97E-4
10 SGTC_923 1900-2434 3.48 73.3 µM 3.69E-5 RNA processing & uracil transport 43 2.55E-4
11 SGTC_3209 9113616 3.47 49.5 µM 3.86E-5 48 2.64E-4
12 SGTC_2301 7769476 3.38 200.0 µM 5.80E-5 34 3.63E-4
13 SGTC_497 capsazepine 3.25 133.0 µM 1.05E-4 35 5.77E-4
14 SGTC_1356 1502-0781 3.08 85.8 µM 2.21E-4 fatty acid desaturase (OLE1) 50 0.00104
15 SGTC_707 0865-0008 3.04 204.0 µM 2.57E-4 DNA damage response 32 0.00117
16 SGTC_632 0781-2353 3.04 4.7 µM 2.57E-4 Golgi 86 0.00117
17 SGTC_2754 granisetron 3.04 64.0 µM 2.67E-4 90 0.00120
18 SGTC_2105 5350118 2.99 200.0 µM 3.26E-4 73 0.00141
19 SGTC_1795 st049545 2.94 62.3 µM 4.04E-4 TSC3-RPN4 47 0.00166
20 SGTC_593 1203-0218 2.82 61.7 µM 6.35E-4 61 0.00238

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 3.41E-15 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.130 4.05E-14 YPR096C YPR096C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.127 1.78E-13 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.124 6.37E-13 YOL137W BSC6 hom Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.121 1.71E-12 YPR201W ARR3 hom Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite
0.119 4.72E-12 YMR061W RNA14 het Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
0.115 2.16E-11 YBR173C UMP1 hom Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly
0.115 2.73E-11 YLR427W MAG2 hom Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1
0.110 1.70E-10 YJL201W ECM25 hom Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
0.110 1.92E-10 YNR049C MSO1 hom Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress
0.109 2.74E-10 YLR307C-A_p YLR307C-A_p hom Putative protein of unknown function
0.099 8.18E-9 YJR053W BFA1 hom Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis
0.099 8.74E-9 YKL193C SDS22 het Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
0.096 2.54E-8 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress
0.095 3.02E-8 YER039C HVG1 hom Protein of unknown function, has homology to Vrg4p