YGL217C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL217C / YGL217C

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.16|P-value:2.19E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.21|P-value:1.26E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.99|P-value:1.22E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.99|P-value:4.09E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:-4.47|P-value:2.85E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.74|P-value:1.45E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:2.89|P-value:6.65E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.07|P-value:2.97E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.63|P-value:2.49E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:3.31|P-value:1.17E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.17|P-value:1.99E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.14|P-value:2.18E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.35|P-value:8.98E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:3.47|P-value:5.72E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.68|P-value:2.13E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.75|P-value:1.39E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.98|P-value:1.54E-8 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.60|P-value:2.79E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:2.95|P-value:5.15E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.74|P-value:1.47E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.84|P-value:8.68E-6 ID:SGTC_1297|Compound:1068-0111|FD-Score:2.84|P-value:7.93E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:2.82|P-value:8.73E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.04|P-value:3.59E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.19|P-value:1.98E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.20|P-value:1.86E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:2.86|P-value:7.40E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.76|P-value:1.45E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.13|P-value:2.15E-6 ID:SGTC_1979|Compound:st071809|FD-Score:3.54|P-value:4.23E-5 ID:SGTC_2057|Compound:5236571|FD-Score:-2.92|P-value:5.45E-4 ID:SGTC_2162|Compound:5663267|FD-Score:2.89|P-value:6.65E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.40|P-value:7.89E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-3.63|P-value:2.50E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-2.97|P-value:4.36E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.46|P-value:6.09E-5 ID:SGTC_2437|Compound:5741531|FD-Score:3.24|P-value:1.61E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.08|P-value:3.16E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.58|P-value:3.36E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.76|P-value:1.28E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.40|P-value:7.92E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.06|P-value:3.13E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:6.89|P-value:8.24E-15 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.84|P-value:9.58E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.13|P-value:2.50E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:2.87|P-value:7.05E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.39|P-value:8.17E-5 ID:SGTC_2602|Compound:kawain|FD-Score:2.84|P-value:8.01E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:2.83|P-value:8.33E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-2.94|P-value:4.98E-4 ID:SGTC_2848|Compound:9016370|FD-Score:4.68|P-value:9.40E-8 ID:SGTC_2850|Compound:9015429|FD-Score:2.80|P-value:9.19E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.16|P-value:2.19E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.21|P-value:1.26E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.99|P-value:1.22E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.99|P-value:4.09E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:-4.47|P-value:2.85E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.74|P-value:1.45E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:2.89|P-value:6.65E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.07|P-value:2.97E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.63|P-value:2.49E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:3.31|P-value:1.17E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.17|P-value:1.99E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.14|P-value:2.18E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.35|P-value:8.98E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:3.47|P-value:5.72E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.68|P-value:2.13E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.75|P-value:1.39E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.98|P-value:1.54E-8 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.60|P-value:2.79E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:2.95|P-value:5.15E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.74|P-value:1.47E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.84|P-value:8.68E-6 ID:SGTC_1297|Compound:1068-0111|FD-Score:2.84|P-value:7.93E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:2.82|P-value:8.73E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.04|P-value:3.59E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.19|P-value:1.98E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.20|P-value:1.86E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:2.86|P-value:7.40E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.76|P-value:1.45E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.13|P-value:2.15E-6 ID:SGTC_1979|Compound:st071809|FD-Score:3.54|P-value:4.23E-5 ID:SGTC_2057|Compound:5236571|FD-Score:-2.92|P-value:5.45E-4 ID:SGTC_2162|Compound:5663267|FD-Score:2.89|P-value:6.65E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.40|P-value:7.89E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-3.63|P-value:2.50E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-2.97|P-value:4.36E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.46|P-value:6.09E-5 ID:SGTC_2437|Compound:5741531|FD-Score:3.24|P-value:1.61E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.08|P-value:3.16E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.58|P-value:3.36E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.76|P-value:1.28E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.40|P-value:7.92E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.06|P-value:3.13E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:6.89|P-value:8.24E-15 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.84|P-value:9.58E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.13|P-value:2.50E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:2.87|P-value:7.05E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.39|P-value:8.17E-5 ID:SGTC_2602|Compound:kawain|FD-Score:2.84|P-value:8.01E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:2.83|P-value:8.33E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-2.94|P-value:4.98E-4 ID:SGTC_2848|Compound:9016370|FD-Score:4.68|P-value:9.40E-8 ID:SGTC_2850|Compound:9015429|FD-Score:2.80|P-value:9.19E-4

Top fitness defect scores for YGL217C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2564 betulinic acid 6.89 100.0 µM 8.24E-15 4 2.72E-12
2 SGTC_1089 terbinafine 4.98 2.2 µM 1.54E-8 6 3.25E-7
3 SGTC_2848 9016370 4.68 26.0 µM 9.40E-8 11 1.41E-6
4 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.13 70.1 µM 2.15E-6 21 1.79E-5
5 SGTC_2583 asiatic acid 3.84 100.0 µM 9.58E-6 42 6.06E-5
6 SGTC_1916 st067606 3.76 49.2 µM 1.45E-5 45 8.49E-5
7 SGTC_1012 4112-3522 3.68 18.0 µM 2.13E-5 27 1.16E-4
8 SGTC_2497 7-hydroxyflavone 3.58 100.0 µM 3.36E-5 24 1.69E-4
9 SGTC_1979 st071809 3.54 45.3 µM 4.23E-5 RPP1 & pyrimidine depletion 25 2.03E-4
10 SGTC_981 1488-1094 3.47 54.9 µM 5.72E-5 33 2.60E-4
11 SGTC_2372 9071633 3.46 200.0 µM 6.09E-5 22 2.74E-4
12 SGTC_2175 5807670 3.40 165.3 µM 7.89E-5 34 3.38E-4
13 SGTC_2537 larixol 3.40 68.9 µM 7.92E-5 44 3.39E-4
14 SGTC_2595 hexamethylquercetagetin 3.39 100.0 µM 8.17E-5 49 3.48E-4
15 SGTC_721 1187-1332 3.31 279.0 µM 1.17E-4 cell wall signaling 30 4.68E-4
16 SGTC_2437 5741531 3.24 144.2 µM 1.61E-4 70 6.06E-4
17 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 3.20 85.4 µM 1.86E-4 54 6.82E-4
18 SGTC_1565 sinapyl alcohol 3.19 95.1 µM 1.98E-4 67 7.17E-4
19 SGTC_65 0798-0905 3.16 35.0 µM 2.19E-4 calcium & mitochondrial duress 146 7.79E-4
20 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 3.13 100.0 µM 2.50E-4 60S ribosome export 57 8.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 9.58E-19 YGL235W_p YGL235W_p hom Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.133 9.11E-15 YBR070C ALG14 het Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
0.128 1.23E-13 YCR088W ABP1 hom Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences
0.121 2.33E-12 YKL023W_p YKL023W_p hom Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.118 6.84E-12 YDL114W_p YDL114W_p hom Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene
0.112 9.41E-11 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.108 3.25E-10 YDL225W SHS1 hom Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress
0.108 3.37E-10 YER093C TSC11 het Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain
0.106 8.70E-10 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.104 1.66E-9 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.101 4.02E-9 YBR205W KTR3 hom Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
0.101 4.63E-9 YBL063W KIP1 hom Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions
0.098 1.49E-8 YOL133W HRT1 het RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF
0.094 4.52E-8 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.091 1.18E-7 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion