YGL234W / ADE5,7

Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL234W / ADE5,7

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.58|P-value:1.14E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.71|P-value:6.66E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:3.92|P-value:2.73E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:5.95|P-value:4.66E-10 ID:SGTC_97|Compound:0535-0701|FD-Score:3.75|P-value:5.65E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:15.30|P-value:2.34E-56 ID:SGTC_146|Compound:3448-8650|FD-Score:5.84|P-value:9.10E-10 ID:SGTC_151|Compound:3013-0144|FD-Score:3.83|P-value:4.09E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.92|P-value:2.60E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:4.89|P-value:2.37E-7 ID:SGTC_251|Compound:melphalan|FD-Score:3.42|P-value:2.20E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.17|P-value:5.67E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.02|P-value:9.24E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.22|P-value:4.62E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.01|P-value:9.66E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.05|P-value:1.52E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.93|P-value:1.93E-7 ID:SGTC_830|Compound:4076-0286|FD-Score:3.27|P-value:3.90E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.40|P-value:2.94E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:3.18|P-value:5.46E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.71|P-value:6.89E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:3.18|P-value:5.34E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:5.49|P-value:7.89E-9 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.25|P-value:4.12E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.39|P-value:2.47E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.18|P-value:5.39E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.86|P-value:3.56E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:4.47|P-value:2.08E-6 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.35|P-value:2.90E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.45|P-value:1.92E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.25|P-value:6.06E-6 ID:SGTC_1730|Compound:st033808|FD-Score:3.79|P-value:4.92E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.44|P-value:2.05E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.29|P-value:3.37E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.03|P-value:8.73E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.00|P-value:9.83E-4 ID:SGTC_2142|Compound:5622915|FD-Score:6.02|P-value:2.87E-10 ID:SGTC_2166|Compound:5933061|FD-Score:4.99|P-value:1.44E-7 ID:SGTC_2245|Compound:6637752|FD-Score:7.42|P-value:1.11E-14 ID:SGTC_2318|Compound:6029776|FD-Score:-3.62|P-value:9.34E-5 ID:SGTC_2414|Compound:st077232|FD-Score:3.07|P-value:8.01E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.84|P-value:3.66E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:8.66|P-value:2.47E-19 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.92|P-value:2.81E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.14|P-value:6.30E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.85|P-value:3.75E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-6.68|P-value:2.72E-12 ID:SGTC_2937|Compound:9044753|FD-Score:3.20|P-value:4.90E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.23|P-value:4.52E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.88|P-value:2.51E-7 ID:SGTC_3083|Compound:9117465|FD-Score:3.56|P-value:1.26E-4 ID:SGTC_3244|Compound:9134489|FD-Score:11.10|P-value:2.34E-30 ID:SGTC_7|Compound:0192-1582|FD-Score:3.58|P-value:1.14E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.71|P-value:6.66E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:3.92|P-value:2.73E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:5.95|P-value:4.66E-10 ID:SGTC_97|Compound:0535-0701|FD-Score:3.75|P-value:5.65E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:15.30|P-value:2.34E-56 ID:SGTC_146|Compound:3448-8650|FD-Score:5.84|P-value:9.10E-10 ID:SGTC_151|Compound:3013-0144|FD-Score:3.83|P-value:4.09E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.92|P-value:2.60E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:4.89|P-value:2.37E-7 ID:SGTC_251|Compound:melphalan|FD-Score:3.42|P-value:2.20E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.17|P-value:5.67E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.02|P-value:9.24E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.22|P-value:4.62E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.01|P-value:9.66E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.05|P-value:1.52E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.93|P-value:1.93E-7 ID:SGTC_830|Compound:4076-0286|FD-Score:3.27|P-value:3.90E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.40|P-value:2.94E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:3.18|P-value:5.46E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.71|P-value:6.89E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:3.18|P-value:5.34E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:5.49|P-value:7.89E-9 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.25|P-value:4.12E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.39|P-value:2.47E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.18|P-value:5.39E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.86|P-value:3.56E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:4.47|P-value:2.08E-6 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.35|P-value:2.90E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.45|P-value:1.92E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.25|P-value:6.06E-6 ID:SGTC_1730|Compound:st033808|FD-Score:3.79|P-value:4.92E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.44|P-value:2.05E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.29|P-value:3.37E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.03|P-value:8.73E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.00|P-value:9.83E-4 ID:SGTC_2142|Compound:5622915|FD-Score:6.02|P-value:2.87E-10 ID:SGTC_2166|Compound:5933061|FD-Score:4.99|P-value:1.44E-7 ID:SGTC_2245|Compound:6637752|FD-Score:7.42|P-value:1.11E-14 ID:SGTC_2318|Compound:6029776|FD-Score:-3.62|P-value:9.34E-5 ID:SGTC_2414|Compound:st077232|FD-Score:3.07|P-value:8.01E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.84|P-value:3.66E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:8.66|P-value:2.47E-19 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.92|P-value:2.81E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.14|P-value:6.30E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.85|P-value:3.75E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-6.68|P-value:2.72E-12 ID:SGTC_2937|Compound:9044753|FD-Score:3.20|P-value:4.90E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.23|P-value:4.52E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.88|P-value:2.51E-7 ID:SGTC_3083|Compound:9117465|FD-Score:3.56|P-value:1.26E-4 ID:SGTC_3244|Compound:9134489|FD-Score:11.10|P-value:2.34E-30

Top fitness defect scores for YGL234W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_123 0083-0120 15.30 66.7 µM 2.34E-56 4 3.08E-53
2 SGTC_3244 9134489 11.10 49.5 µM 2.34E-30 4 9.87E-29
3 SGTC_2594 a-mangostin 8.66 100.0 µM 2.47E-19 2 2.44E-18
4 SGTC_2245 6637752 7.42 200.0 µM 1.11E-14 4 5.98E-14
5 SGTC_2142 5622915 6.02 118.5 µM 2.87E-10 2 8.70E-10
6 SGTC_87 0100-0052 5.95 35.5 µM 4.66E-10 33 1.37E-9
7 SGTC_146 3448-8650 5.84 53.1 µM 9.10E-10 NEO1-PIK1 58 2.59E-9
8 SGTC_965 1291-5240 5.49 308.0 µM 7.89E-9 12 1.99E-8
9 SGTC_2166 5933061 4.99 31.5 µM 1.44E-7 tubulin folding & SWR complex 18 3.08E-7
10 SGTC_800 3448-7362 4.93 155.0 µM 1.93E-7 translation 92 4.07E-7
11 SGTC_163 1327-0036 4.89 7.5 µM 2.37E-7 67 4.94E-7
12 SGTC_2958 9077254 4.88 16.7 µM 2.51E-7 10 5.22E-7
13 SGTC_1136 pergolide 4.47 1.1 µM 2.08E-6 26 3.86E-6
14 SGTC_832 4083-0019 4.40 164.0 µM 2.94E-6 translation 67 5.35E-6
15 SGTC_1557 sumaresinolic acid 4.25 42.3 µM 6.06E-6 12 1.06E-5
16 SGTC_789 1309-1135 4.05 70.6 µM 1.52E-5 ERG2 27 2.52E-5
17 SGTC_52 0329-0193 3.92 875.0 nM 2.73E-5 TSC3-RPN4 34 4.39E-5
18 SGTC_2597 laccaic acid a 3.92 100.0 µM 2.81E-5 36 4.51E-5
19 SGTC_1122 capsaicin 3.86 818.6 nM 3.56E-5 31 5.65E-5
20 SGTC_2919 7978188 3.85 46.4 µM 3.75E-5 22 5.94E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.473 1.08E-186 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.375 1.63E-112 YGR061C ADE6 hom Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.371 3.49E-110 YLR058C SHM2 hom Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
0.300 1.19E-70 YMR300C ADE4 hom Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
0.279 7.52E-61 YDR408C ADE8 hom Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.140 4.82E-16 YMR120C ADE17 hom Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
0.127 1.35E-13 YKR080W MTD1 hom NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
0.125 3.84E-13 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.124 4.72E-13 YNL032W SIW14 hom Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
0.123 9.47E-13 YOL035C_d YOL035C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.112 6.93E-11 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.102 3.58E-9 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.102 3.62E-9 YGR273C_p YGR273C_p hom Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene
0.101 5.44E-9 YJR118C ILM1 hom Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth
0.100 6.49E-9 YEL013W VAC8 hom Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions