YGL237C / HAP2

Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL237C / HAP2

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.68|P-value:3.51E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.97|P-value:1.20E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.43|P-value:1.35E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.67|P-value:4.78E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:3.89|P-value:1.85E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:29.70|P-value:9.61E-219 ID:SGTC_300|Compound:r073-0011|FD-Score:3.04|P-value:6.32E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.08|P-value:7.50E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:-4.13|P-value:5.76E-6 ID:SGTC_865|Compound:0488-0499|FD-Score:3.24|P-value:3.00E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.47|P-value:1.15E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.00|P-value:7.30E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:4.23|P-value:3.53E-6 ID:SGTC_978|Compound:1416-0512|FD-Score:3.12|P-value:4.76E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.39|P-value:1.59E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.91|P-value:1.66E-5 ID:SGTC_1092|Compound:toremifene|FD-Score:3.88|P-value:1.92E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.49|P-value:1.09E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.58|P-value:7.18E-5 ID:SGTC_1635|Compound:st007035|FD-Score:9.64|P-value:6.83E-25 ID:SGTC_1651|Compound:st011928|FD-Score:3.51|P-value:9.76E-5 ID:SGTC_1653|Compound:st012112|FD-Score:2.94|P-value:9.00E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.24|P-value:2.92E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.77|P-value:3.16E-5 ID:SGTC_1980|Compound:st071811|FD-Score:-3.47|P-value:1.11E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.00|P-value:7.41E-4 ID:SGTC_2295|Compound:7971645|FD-Score:4.60|P-value:5.29E-7 ID:SGTC_2303|Compound:7774051|FD-Score:3.41|P-value:1.49E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-4.10|P-value:6.49E-6 ID:SGTC_2485|Compound:5633444|FD-Score:3.63|P-value:5.83E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.30|P-value:2.22E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.30|P-value:2.35E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.89|P-value:1.81E-5 ID:SGTC_2701|Compound:st077767|FD-Score:-3.26|P-value:2.65E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.64|P-value:5.75E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.82|P-value:2.51E-5 ID:SGTC_2846|Compound:9008642|FD-Score:4.47|P-value:1.06E-6 ID:SGTC_2958|Compound:9077254|FD-Score:3.00|P-value:7.31E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.14|P-value:4.28E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.26|P-value:2.67E-4 ID:SGTC_3114|Compound:9122766|FD-Score:4.28|P-value:2.75E-6 ID:SGTC_3218|Compound:9131285|FD-Score:5.20|P-value:1.77E-8 ID:SGTC_3223|Compound:9129970|FD-Score:4.41|P-value:1.48E-6 ID:SGTC_3224|Compound:9130643|FD-Score:-3.23|P-value:2.94E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:4.68|P-value:3.51E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.97|P-value:1.20E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.43|P-value:1.35E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.67|P-value:4.78E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:3.89|P-value:1.85E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:29.70|P-value:9.61E-219 ID:SGTC_300|Compound:r073-0011|FD-Score:3.04|P-value:6.32E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.08|P-value:7.50E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:-4.13|P-value:5.76E-6 ID:SGTC_865|Compound:0488-0499|FD-Score:3.24|P-value:3.00E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.47|P-value:1.15E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.00|P-value:7.30E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:4.23|P-value:3.53E-6 ID:SGTC_978|Compound:1416-0512|FD-Score:3.12|P-value:4.76E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.39|P-value:1.59E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.91|P-value:1.66E-5 ID:SGTC_1092|Compound:toremifene|FD-Score:3.88|P-value:1.92E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.49|P-value:1.09E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.58|P-value:7.18E-5 ID:SGTC_1635|Compound:st007035|FD-Score:9.64|P-value:6.83E-25 ID:SGTC_1651|Compound:st011928|FD-Score:3.51|P-value:9.76E-5 ID:SGTC_1653|Compound:st012112|FD-Score:2.94|P-value:9.00E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.24|P-value:2.92E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.77|P-value:3.16E-5 ID:SGTC_1980|Compound:st071811|FD-Score:-3.47|P-value:1.11E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.00|P-value:7.41E-4 ID:SGTC_2295|Compound:7971645|FD-Score:4.60|P-value:5.29E-7 ID:SGTC_2303|Compound:7774051|FD-Score:3.41|P-value:1.49E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-4.10|P-value:6.49E-6 ID:SGTC_2485|Compound:5633444|FD-Score:3.63|P-value:5.83E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.30|P-value:2.22E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.30|P-value:2.35E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.89|P-value:1.81E-5 ID:SGTC_2701|Compound:st077767|FD-Score:-3.26|P-value:2.65E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.64|P-value:5.75E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.82|P-value:2.51E-5 ID:SGTC_2846|Compound:9008642|FD-Score:4.47|P-value:1.06E-6 ID:SGTC_2958|Compound:9077254|FD-Score:3.00|P-value:7.31E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.14|P-value:4.28E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.26|P-value:2.67E-4 ID:SGTC_3114|Compound:9122766|FD-Score:4.28|P-value:2.75E-6 ID:SGTC_3218|Compound:9131285|FD-Score:5.20|P-value:1.77E-8 ID:SGTC_3223|Compound:9129970|FD-Score:4.41|P-value:1.48E-6 ID:SGTC_3224|Compound:9130643|FD-Score:-3.23|P-value:2.94E-4

Top fitness defect scores for YGL237C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 29.70 5.3 µM 9.61E-219 14 2.38E-194
2 SGTC_1635 st007035 9.64 42.4 µM 6.83E-25 78 2.60E-22
3 SGTC_3218 9131285 5.20 49.5 µM 1.77E-8 endomembrane recycling 12 1.02E-7
4 SGTC_15 0266-0086 4.68 27.1 µM 3.51E-7 endomembrane recycling 39 1.46E-6
5 SGTC_2295 7971645 4.60 200.0 µM 5.29E-7 13 2.11E-6
6 SGTC_2846 9008642 4.47 19.5 µM 1.06E-6 14 3.92E-6
7 SGTC_3223 9129970 4.41 49.5 µM 1.48E-6 15 5.27E-6
8 SGTC_3114 9122766 4.28 49.5 µM 2.75E-6 12 9.19E-6
9 SGTC_933 2914-0560 4.23 114.0 µM 3.53E-6 20 1.15E-5
10 SGTC_310 1273-0058 4.08 1.1 µM 7.50E-6 mitochondrial stress 233 2.25E-5
11 SGTC_1003 4049-0218 3.91 100.0 µM 1.66E-5 16 4.58E-5
12 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.89 70.0 µM 1.81E-5 redox potentiating 74 4.93E-5
13 SGTC_212 3807-4682 3.89 38.8 µM 1.85E-5 tubulin folding & SWR complex 70 5.03E-5
14 SGTC_1092 toremifene 3.88 6.3 µM 1.92E-5 20 5.19E-5
15 SGTC_2812 7970281 3.82 58.4 µM 2.51E-5 34 6.61E-5
16 SGTC_1718 roemerine 3.77 11.9 µM 3.16E-5 redox potentiating 62 8.13E-5
17 SGTC_2759 disulfiram 3.64 3.4 µM 5.75E-5 50 1.39E-4
18 SGTC_2485 5633444 3.63 17.8 µM 5.83E-5 redox potentiating 59 1.40E-4
19 SGTC_1519 esterone 3.58 74.0 µM 7.18E-5 DNA intercalators 29 1.69E-4
20 SGTC_1651 st011928 3.51 86.1 µM 9.76E-5 RSC complex & mRNA processing 21 2.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.685 0 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.671 0 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.655 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.616 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.609 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.605 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.594 5.74E-319 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.588 1.49E-311 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.586 3.01E-308 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.576 1.69E-295 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.570 1.35E-287 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.566 4.25E-283 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.554 4.27E-269 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.551 3.02E-265 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.543 1.56E-256 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome