YGL240W / DOC1

Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL240W / DOC1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:8.97|P-value:1.97E-18 ID:SGTC_37|Compound:0566-0070|FD-Score:3.31|P-value:6.97E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.90|P-value:8.36E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.59|P-value:2.60E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.62|P-value:2.33E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.13|P-value:3.36E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:4.52|P-value:6.40E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:4.18|P-value:2.74E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.83|P-value:1.53E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:5.37|P-value:1.04E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:8.80|P-value:8.37E-18 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.02|P-value:2.87E-9 ID:SGTC_294|Compound:k038-0071|FD-Score:3.32|P-value:6.72E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.65|P-value:2.11E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-6.05|P-value:2.20E-9 ID:SGTC_351|Compound:caspofungin|FD-Score:3.42|P-value:4.85E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.82|P-value:1.10E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.58|P-value:2.76E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.00|P-value:6.75E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:-6.24|P-value:7.36E-10 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.54|P-value:2.97E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.69|P-value:1.82E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.63|P-value:2.26E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.42|P-value:4.83E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.78|P-value:1.31E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.21|P-value:9.55E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-4.02|P-value:4.79E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:4.71|P-value:2.63E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:4.60|P-value:4.30E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:4.06|P-value:4.38E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.21|P-value:9.83E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.49|P-value:3.75E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.36|P-value:5.96E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.86|P-value:9.66E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.60|P-value:2.53E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.59|P-value:2.67E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.93|P-value:7.21E-5 ID:SGTC_1606|Compound:st000094|FD-Score:4.77|P-value:1.98E-6 ID:SGTC_1630|Compound:st005209|FD-Score:3.92|P-value:7.49E-5 ID:SGTC_1937|Compound:st074714|FD-Score:-3.47|P-value:3.81E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.75|P-value:1.45E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-5.21|P-value:2.12E-7 ID:SGTC_2051|Compound:5263410|FD-Score:3.57|P-value:2.82E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.51|P-value:3.50E-4 ID:SGTC_2077|Compound:5212015|FD-Score:5.42|P-value:8.04E-8 ID:SGTC_2218|Compound:6965428|FD-Score:5.37|P-value:1.02E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.40|P-value:5.17E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-3.38|P-value:5.19E-4 ID:SGTC_2393|Compound:9031399|FD-Score:4.21|P-value:2.37E-5 ID:SGTC_2397|Compound:5161689|FD-Score:4.88|P-value:1.18E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.76|P-value:1.43E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.50|P-value:3.58E-4 ID:SGTC_2434|Compound:5670830|FD-Score:5.31|P-value:1.41E-7 ID:SGTC_2437|Compound:5741531|FD-Score:3.28|P-value:7.79E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.34|P-value:5.96E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.47|P-value:7.10E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.52|P-value:6.24E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.58|P-value:4.76E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.41|P-value:4.66E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.30|P-value:7.16E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.83|P-value:1.00E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.21|P-value:9.79E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.27|P-value:7.84E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.52|P-value:3.42E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.29|P-value:7.33E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.45|P-value:4.11E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.32|P-value:6.69E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:8.97|P-value:1.97E-18 ID:SGTC_37|Compound:0566-0070|FD-Score:3.31|P-value:6.97E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.90|P-value:8.36E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.59|P-value:2.60E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.62|P-value:2.33E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.13|P-value:3.36E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:4.52|P-value:6.40E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:4.18|P-value:2.74E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.83|P-value:1.53E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:5.37|P-value:1.04E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:8.80|P-value:8.37E-18 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.02|P-value:2.87E-9 ID:SGTC_294|Compound:k038-0071|FD-Score:3.32|P-value:6.72E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.65|P-value:2.11E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-6.05|P-value:2.20E-9 ID:SGTC_351|Compound:caspofungin|FD-Score:3.42|P-value:4.85E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.82|P-value:1.10E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.58|P-value:2.76E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.00|P-value:6.75E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:-6.24|P-value:7.36E-10 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.54|P-value:2.97E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.69|P-value:1.82E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.63|P-value:2.26E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.42|P-value:4.83E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.78|P-value:1.31E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.21|P-value:9.55E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-4.02|P-value:4.79E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:4.71|P-value:2.63E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:4.60|P-value:4.30E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:4.06|P-value:4.38E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.21|P-value:9.83E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.49|P-value:3.75E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.36|P-value:5.96E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.86|P-value:9.66E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.60|P-value:2.53E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.59|P-value:2.67E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.93|P-value:7.21E-5 ID:SGTC_1606|Compound:st000094|FD-Score:4.77|P-value:1.98E-6 ID:SGTC_1630|Compound:st005209|FD-Score:3.92|P-value:7.49E-5 ID:SGTC_1937|Compound:st074714|FD-Score:-3.47|P-value:3.81E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.75|P-value:1.45E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-5.21|P-value:2.12E-7 ID:SGTC_2051|Compound:5263410|FD-Score:3.57|P-value:2.82E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.51|P-value:3.50E-4 ID:SGTC_2077|Compound:5212015|FD-Score:5.42|P-value:8.04E-8 ID:SGTC_2218|Compound:6965428|FD-Score:5.37|P-value:1.02E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.40|P-value:5.17E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-3.38|P-value:5.19E-4 ID:SGTC_2393|Compound:9031399|FD-Score:4.21|P-value:2.37E-5 ID:SGTC_2397|Compound:5161689|FD-Score:4.88|P-value:1.18E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.76|P-value:1.43E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.50|P-value:3.58E-4 ID:SGTC_2434|Compound:5670830|FD-Score:5.31|P-value:1.41E-7 ID:SGTC_2437|Compound:5741531|FD-Score:3.28|P-value:7.79E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.34|P-value:5.96E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.47|P-value:7.10E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.52|P-value:6.24E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.58|P-value:4.76E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.41|P-value:4.66E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.30|P-value:7.16E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.83|P-value:1.00E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.21|P-value:9.79E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.27|P-value:7.84E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.52|P-value:3.42E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.29|P-value:7.33E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.45|P-value:4.11E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.32|P-value:6.69E-4

Top fitness defect scores for YGL240W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_36 0335-0881 8.97 14.2 µM 1.97E-18 ubiquinone biosynthesis & proteasome 26 1.43E-19
2 SGTC_236 1509-0011 8.80 5.3 µM 8.37E-18 226 6.70E-19
3 SGTC_275 trichlorophene 6.02 5.7 µM 2.87E-9 mitochondrial stress 117 8.52E-10
4 SGTC_2077 5212015 5.42 200.0 µM 8.04E-8 30 2.98E-8
5 SGTC_2218 6965428 5.37 193.0 µM 1.02E-7 TSC3-RPN4 3 3.85E-8
6 SGTC_158 k038-0087 5.37 26.4 µM 1.04E-7 ubiquinone biosynthesis & proteasome 83 3.92E-8
7 SGTC_2434 5670830 5.31 169.9 µM 1.41E-7 7 5.44E-8
8 SGTC_367 0335-0881 5.00 7.1 µM 6.75E-7 ubiquinone biosynthesis & proteasome 41 2.88E-7
9 SGTC_2397 5161689 4.88 200.0 µM 1.18E-6 16 5.21E-7
10 SGTC_118 0083-0097 4.83 135.3 µM 1.53E-6 translation 69 6.87E-7
11 SGTC_1606 st000094 4.77 49.2 µM 1.98E-6 60S ribosome export 5 9.06E-7
12 SGTC_830 4076-0286 4.71 57.8 µM 2.63E-6 translation 37 1.23E-6
13 SGTC_832 4083-0019 4.60 164.0 µM 4.30E-6 translation 58 2.07E-6
14 SGTC_2578 7,8-dihydroxyflavone 4.58 64.4 µM 4.76E-6 22 2.31E-6
15 SGTC_2567 aureobasidin a 4.52 60.0 nM 6.24E-6 72 3.08E-6
16 SGTC_84 0443-0269 4.52 128.8 µM 6.40E-6 13 3.16E-6
17 SGTC_2393 9031399 4.21 185.9 µM 2.37E-5 RNA processing & uracil transport 21 1.27E-5
18 SGTC_86 0417-1630 4.18 471.9 µM 2.74E-5 ubiquinone biosynthesis & proteasome 140 1.49E-5
19 SGTC_67 0335-0847 4.13 266.0 µM 3.36E-5 ubiquinone biosynthesis & proteasome 108 1.85E-5
20 SGTC_1074 carmofur 4.06 3.8 µM 4.38E-5 exosome 19 2.45E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.351 3.31E-98 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.342 1.61E-92 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.340 1.27E-91 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.316 9.81E-79 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.310 1.19E-75 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.310 1.78E-75 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.304 7.57E-73 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.287 1.62E-64 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.286 4.83E-64 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.266 3.32E-55 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.262 1.31E-53 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.259 1.09E-52 YKL016C ATP7 hom Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.257 1.24E-51 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.254 9.70E-51 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.252 9.00E-50 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells