YGL252C / RTG2

Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL252C / RTG2

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:5.90|P-value:6.43E-8 ID:SGTC_141|Compound:0443-0274|FD-Score:4.80|P-value:8.49E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:3.58|P-value:6.72E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:3.46|P-value:9.60E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.59|P-value:1.99E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-4.11|P-value:1.30E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:4.03|P-value:1.53E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.46|P-value:3.70E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:7.78|P-value:1.77E-12 ID:SGTC_393|Compound:acivicin|FD-Score:5.48|P-value:4.69E-7 ID:SGTC_394|Compound:menadione|FD-Score:3.57|P-value:6.93E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.68|P-value:5.34E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.71|P-value:4.43E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.74|P-value:1.08E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.57|P-value:3.66E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.90|P-value:2.61E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.47|P-value:9.27E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.57|P-value:6.77E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:8.75|P-value:2.57E-15 ID:SGTC_778|Compound:3456-2434|FD-Score:7.97|P-value:5.24E-13 ID:SGTC_852|Compound:0418-0143|FD-Score:3.55|P-value:7.29E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.47|P-value:9.36E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.87|P-value:2.58E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.43|P-value:3.57E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:5.46|P-value:5.13E-7 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.91|P-value:5.48E-6 ID:SGTC_1658|Compound:st012944|FD-Score:3.61|P-value:5.99E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.34|P-value:8.50E-9 ID:SGTC_1754|Compound:st042065|FD-Score:-3.94|P-value:2.34E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.19|P-value:9.84E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.20|P-value:9.44E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:11.60|P-value:1.23E-25 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.62|P-value:1.62E-9 ID:SGTC_2054|Compound:5233173|FD-Score:3.58|P-value:6.66E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.66|P-value:1.53E-5 ID:SGTC_2122|Compound:5258151|FD-Score:-3.48|P-value:9.97E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.88|P-value:2.81E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.80|P-value:9.93E-6 ID:SGTC_2264|Compound:7948757|FD-Score:-4.33|P-value:5.84E-5 ID:SGTC_2423|Compound:st077119|FD-Score:-3.70|P-value:5.10E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.65|P-value:5.85E-4 ID:SGTC_2430|Compound:5571206|FD-Score:13.90|P-value:7.15E-36 ID:SGTC_2431|Compound:5490079|FD-Score:-4.57|P-value:2.37E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.33|P-value:5.85E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.76|P-value:3.80E-4 ID:SGTC_2625|Compound:euphol|FD-Score:5.20|P-value:1.58E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:10.80|P-value:1.75E-22 ID:SGTC_2701|Compound:st077767|FD-Score:4.21|P-value:8.07E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-3.95|P-value:2.21E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.51|P-value:8.36E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.77|P-value:4.00E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.29|P-value:6.04E-5 ID:SGTC_3240|Compound:9133527|FD-Score:3.46|P-value:9.49E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.63|P-value:5.76E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.89|P-value:2.44E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.90|P-value:6.43E-8 ID:SGTC_141|Compound:0443-0274|FD-Score:4.80|P-value:8.49E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:3.58|P-value:6.72E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:3.46|P-value:9.60E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.59|P-value:1.99E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-4.11|P-value:1.30E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:4.03|P-value:1.53E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.46|P-value:3.70E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:7.78|P-value:1.77E-12 ID:SGTC_393|Compound:acivicin|FD-Score:5.48|P-value:4.69E-7 ID:SGTC_394|Compound:menadione|FD-Score:3.57|P-value:6.93E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.68|P-value:5.34E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.71|P-value:4.43E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.74|P-value:1.08E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.57|P-value:3.66E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.90|P-value:2.61E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.47|P-value:9.27E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.57|P-value:6.77E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:8.75|P-value:2.57E-15 ID:SGTC_778|Compound:3456-2434|FD-Score:7.97|P-value:5.24E-13 ID:SGTC_852|Compound:0418-0143|FD-Score:3.55|P-value:7.29E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.47|P-value:9.36E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.87|P-value:2.58E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.43|P-value:3.57E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:5.46|P-value:5.13E-7 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.91|P-value:5.48E-6 ID:SGTC_1658|Compound:st012944|FD-Score:3.61|P-value:5.99E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.34|P-value:8.50E-9 ID:SGTC_1754|Compound:st042065|FD-Score:-3.94|P-value:2.34E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.19|P-value:9.84E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.20|P-value:9.44E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:11.60|P-value:1.23E-25 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.62|P-value:1.62E-9 ID:SGTC_2054|Compound:5233173|FD-Score:3.58|P-value:6.66E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.66|P-value:1.53E-5 ID:SGTC_2122|Compound:5258151|FD-Score:-3.48|P-value:9.97E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.88|P-value:2.81E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.80|P-value:9.93E-6 ID:SGTC_2264|Compound:7948757|FD-Score:-4.33|P-value:5.84E-5 ID:SGTC_2423|Compound:st077119|FD-Score:-3.70|P-value:5.10E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.65|P-value:5.85E-4 ID:SGTC_2430|Compound:5571206|FD-Score:13.90|P-value:7.15E-36 ID:SGTC_2431|Compound:5490079|FD-Score:-4.57|P-value:2.37E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.33|P-value:5.85E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.76|P-value:3.80E-4 ID:SGTC_2625|Compound:euphol|FD-Score:5.20|P-value:1.58E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:10.80|P-value:1.75E-22 ID:SGTC_2701|Compound:st077767|FD-Score:4.21|P-value:8.07E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-3.95|P-value:2.21E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.51|P-value:8.36E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.77|P-value:4.00E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.29|P-value:6.04E-5 ID:SGTC_3240|Compound:9133527|FD-Score:3.46|P-value:9.49E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.63|P-value:5.76E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.89|P-value:2.44E-4

Top fitness defect scores for YGL252C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2430 5571206 13.90 200.0 µM 7.15E-36 2 2.02E-44
2 SGTC_1844 rapamycin 11.60 4.0 nM 1.23E-25 25 1.32E-31
3 SGTC_2679 rapamycin 10.80 1.0 nM 1.75E-22 18 1.17E-27
4 SGTC_690 glyoxal 8.75 20.3 µM 2.57E-15 21 1.07E-18
5 SGTC_778 3456-2434 7.97 196.0 µM 5.24E-13 mitochondrial response to ROS 8 8.17E-16
6 SGTC_383 2324-0395 7.78 7.4 µM 1.77E-12 azole & statin 4 3.73E-15
7 SGTC_1877 wortmannin 6.62 25.0 µM 1.62E-9 38 1.85E-11
8 SGTC_116 0155-0182 5.90 31.8 µM 6.43E-8 mitochondrial response to ROS 25 1.81E-9
9 SGTC_393 acivicin 5.48 6.2 µM 4.69E-7 9 2.14E-8
10 SGTC_1310 1188-0297 5.46 994.0 nM 5.13E-7 azole & statin 10 2.40E-8
11 SGTC_2625 euphol 5.20 100.0 µM 1.58E-6 10 9.71E-8
12 SGTC_1353 1498-1206 4.91 8.1 µM 5.48E-6 mitochondrial response to ROS 30 4.54E-7
13 SGTC_141 0443-0274 4.80 32.3 µM 8.49E-6 mitochondrial response to ROS 26 7.81E-7
14 SGTC_419 nsc-638432 4.74 893.0 µM 1.08E-5 DNA damage response 3 1.05E-6
15 SGTC_2085 5307070 4.66 144.1 µM 1.53E-5 superoxide 15 1.61E-6
16 SGTC_210 3551-0445 4.59 56.8 µM 1.99E-5 48 2.25E-6
17 SGTC_1135 dihydrocapsaicin 4.43 536.7 nM 3.57E-5 22 4.63E-6
18 SGTC_3087 9117406 4.29 49.5 µM 6.04E-5 13 8.88E-6
19 SGTC_2701 st077767 4.21 14.7 µM 8.07E-5 38 1.27E-5
20 SGTC_257 daunorubicin 4.03 18.5 µM 1.53E-4 anthracycline transcription coupled DNA repair 20 2.81E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.363 4.72E-105 YOL067C RTG1 hom Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus
0.304 7.40E-73 YBL103C RTG3 hom Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways
0.256 1.53E-51 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.234 9.38E-43 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.220 3.28E-38 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.205 2.61E-33 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.204 7.28E-33 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.201 8.91E-32 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.197 1.54E-30 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.188 3.69E-28 YDL040C NAT1 hom Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
0.184 8.03E-27 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.183 1.58E-26 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.181 4.68E-26 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.179 1.42E-25 YPL170W DAP1 hom Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
0.175 1.84E-24 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4