YGL260W_p

Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL260W / YGL260W

Click on Significant Values for Screen Details ID:SGTC_362|Compound:0310-0100|FD-Score:2.89|P-value:8.51E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.21|P-value:2.27E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:-3.76|P-value:1.97E-5 ID:SGTC_703|Compound:3875-0075|FD-Score:4.20|P-value:2.57E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.28|P-value:1.47E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.22|P-value:2.17E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.51|P-value:6.96E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:3.23|P-value:2.28E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.46|P-value:8.51E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:-4.30|P-value:1.35E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.03|P-value:2.33E-8 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.33|P-value:1.36E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.06|P-value:4.42E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.18|P-value:2.82E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.08|P-value:3.73E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:2.90|P-value:8.18E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.68|P-value:3.17E-5 ID:SGTC_1831|Compound:st055328|FD-Score:2.93|P-value:7.29E-4 ID:SGTC_1833|Compound:st055984|FD-Score:2.95|P-value:6.89E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.20|P-value:2.60E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.25|P-value:1.90E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.40|P-value:1.02E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.74|P-value:1.30E-7 ID:SGTC_2139|Compound:5578692|FD-Score:3.54|P-value:6.14E-5 ID:SGTC_2179|Compound:6298986|FD-Score:3.37|P-value:1.26E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.16|P-value:2.75E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.85|P-value:1.30E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-5.03|P-value:1.97E-8 ID:SGTC_2452|Compound:5863136|FD-Score:-3.15|P-value:2.90E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.28|P-value:1.66E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.16|P-value:3.06E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.11|P-value:3.72E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.19|P-value:2.44E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.25|P-value:1.93E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:2.86|P-value:9.54E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.42|P-value:1.02E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.07|P-value:4.34E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.29|P-value:1.62E-4 ID:SGTC_2798|Compound:7813637|FD-Score:2.92|P-value:7.68E-4 ID:SGTC_2804|Compound:7954240|FD-Score:2.89|P-value:8.64E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-4.87|P-value:5.20E-8 ID:SGTC_3075|Compound:9116269|FD-Score:-3.56|P-value:5.06E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-4.74|P-value:1.10E-7 ID:SGTC_3078|Compound:9116413|FD-Score:-3.96|P-value:7.63E-6 ID:SGTC_3154|Compound:9100113|FD-Score:3.87|P-value:1.30E-5 ID:SGTC_3160|Compound:9100216|FD-Score:3.93|P-value:9.75E-6 ID:SGTC_3186|Compound:9110464|FD-Score:3.51|P-value:6.97E-5 ID:SGTC_3237|Compound:9133362|FD-Score:3.07|P-value:4.33E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.12|P-value:3.55E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:2.89|P-value:8.51E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.21|P-value:2.27E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:-3.76|P-value:1.97E-5 ID:SGTC_703|Compound:3875-0075|FD-Score:4.20|P-value:2.57E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.28|P-value:1.47E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.22|P-value:2.17E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.51|P-value:6.96E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:3.23|P-value:2.28E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.46|P-value:8.51E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:-4.30|P-value:1.35E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.03|P-value:2.33E-8 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.33|P-value:1.36E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.06|P-value:4.42E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.18|P-value:2.82E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.08|P-value:3.73E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:2.90|P-value:8.18E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.68|P-value:3.17E-5 ID:SGTC_1831|Compound:st055328|FD-Score:2.93|P-value:7.29E-4 ID:SGTC_1833|Compound:st055984|FD-Score:2.95|P-value:6.89E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.20|P-value:2.60E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.25|P-value:1.90E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.40|P-value:1.02E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.74|P-value:1.30E-7 ID:SGTC_2139|Compound:5578692|FD-Score:3.54|P-value:6.14E-5 ID:SGTC_2179|Compound:6298986|FD-Score:3.37|P-value:1.26E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.16|P-value:2.75E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.85|P-value:1.30E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-5.03|P-value:1.97E-8 ID:SGTC_2452|Compound:5863136|FD-Score:-3.15|P-value:2.90E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.28|P-value:1.66E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.16|P-value:3.06E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.11|P-value:3.72E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.19|P-value:2.44E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.25|P-value:1.93E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:2.86|P-value:9.54E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.42|P-value:1.02E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.07|P-value:4.34E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.29|P-value:1.62E-4 ID:SGTC_2798|Compound:7813637|FD-Score:2.92|P-value:7.68E-4 ID:SGTC_2804|Compound:7954240|FD-Score:2.89|P-value:8.64E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-4.87|P-value:5.20E-8 ID:SGTC_3075|Compound:9116269|FD-Score:-3.56|P-value:5.06E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-4.74|P-value:1.10E-7 ID:SGTC_3078|Compound:9116413|FD-Score:-3.96|P-value:7.63E-6 ID:SGTC_3154|Compound:9100113|FD-Score:3.87|P-value:1.30E-5 ID:SGTC_3160|Compound:9100216|FD-Score:3.93|P-value:9.75E-6 ID:SGTC_3186|Compound:9110464|FD-Score:3.51|P-value:6.97E-5 ID:SGTC_3237|Compound:9133362|FD-Score:3.07|P-value:4.33E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.12|P-value:3.55E-4

Top fitness defect scores for YGL260W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1129 3453-1384 5.03 223.0 µM 2.33E-8 19 2.48E-7
2 SGTC_2050 5263056 4.74 171.0 µM 1.30E-7 fatty acid desaturase (OLE1) 29 1.07E-6
3 SGTC_2594 a-mangostin 4.25 100.0 µM 1.93E-6 25 1.06E-5
4 SGTC_703 3875-0075 4.20 71.8 µM 2.57E-6 6 1.35E-5
5 SGTC_3160 9100216 3.93 49.5 µM 9.75E-6 7 4.20E-5
6 SGTC_3154 9100113 3.87 49.5 µM 1.30E-5 30 5.35E-5
7 SGTC_1708 st033234 3.68 31.8 µM 3.17E-5 22 1.15E-4
8 SGTC_2139 5578692 3.54 56.5 µM 6.14E-5 superoxide 25 2.02E-4
9 SGTC_736 0958-0254 3.51 92.6 µM 6.96E-5 Golgi 45 2.25E-4
10 SGTC_3186 9110464 3.51 49.5 µM 6.97E-5 RPP1 & pyrimidine depletion 24 2.25E-4
11 SGTC_874 0599-0792 3.46 117.0 µM 8.51E-5 44 2.67E-4
12 SGTC_2676 harmalol 3.42 100.0 µM 1.02E-4 mitochondrial processes 26 3.11E-4
13 SGTC_2179 6298986 3.37 200.0 µM 1.26E-4 heme requiring 30 3.73E-4
14 SGTC_851 0394-0702 3.23 453.0 µM 2.28E-4 mitochondrial processes 27 6.19E-4
15 SGTC_1914 st062367 3.20 72.6 µM 2.60E-4 47 6.92E-4
16 SGTC_1215 3852-0577 3.18 11.2 µM 2.82E-4 40 7.41E-4
17 SGTC_2532 xanthone 3.16 78.9 µM 3.06E-4 57 7.96E-4
18 SGTC_3242 9133940 3.12 49.5 µM 3.55E-4 40 9.05E-4
19 SGTC_2564 betulinic acid 3.11 100.0 µM 3.72E-4 69 9.40E-4
20 SGTC_3237 9133362 3.07 49.5 µM 4.33E-4 66 0.00107

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.206 1.68E-33 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.110 1.48E-10 YDR331W GPI8 het ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
0.105 1.01E-9 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.105 1.25E-9 YOL154W ZPS1 hom Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
0.100 7.13E-9 YDR109C_p YDR109C_p hom Putative kinase
0.100 7.08E-9 YPL019C VTC3 hom Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
0.100 7.61E-9 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.099 9.03E-9 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.098 1.16E-8 YDR167W TAF10 het Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
0.092 8.63E-8 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.092 8.79E-8 YGL184C STR3 hom Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p
0.088 3.35E-7 YGR074W SMD1 het Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1; protein abundance increases in response to DNA replication stress
0.086 6.17E-7 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.085 7.11E-7 YKR010C TOF2 hom Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication
0.083 1.70E-6 YDR257C RKM4 hom Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein