YGR010W / NMA2

Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR010W / NMA2

Click on Significant Values for Screen Details ID:SGTC_283|Compound:0987-0079|FD-Score:-3.30|P-value:4.98E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.55|P-value:3.38E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:3.87|P-value:6.42E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.13|P-value:8.69E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.42|P-value:3.24E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.16|P-value:8.02E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.54|P-value:2.34E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.70|P-value:1.25E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.32|P-value:5.10E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:-3.10|P-value:9.63E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:-3.43|P-value:3.06E-4 ID:SGTC_1650|Compound:st011916|FD-Score:4.45|P-value:5.27E-6 ID:SGTC_1666|Compound:st014829|FD-Score:-3.59|P-value:1.68E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.40|P-value:3.83E-4 ID:SGTC_1977|Compound:st070720|FD-Score:-3.38|P-value:3.73E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-4.40|P-value:5.71E-6 ID:SGTC_2442|Compound:5158906|FD-Score:3.55|P-value:2.22E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.53|P-value:2.13E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.18|P-value:7.50E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-4.60|P-value:2.20E-6 ID:SGTC_2921|Compound:7974240|FD-Score:-4.18|P-value:1.53E-5 ID:SGTC_2927|Compound:9011802|FD-Score:3.61|P-value:1.76E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-4.33|P-value:7.64E-6 ID:SGTC_2951|Compound:9072950|FD-Score:5.60|P-value:1.46E-8 ID:SGTC_2959|Compound:9079155|FD-Score:-4.29|P-value:9.54E-6 ID:SGTC_3070|Compound:9117005|FD-Score:3.31|P-value:5.28E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:-3.30|P-value:4.98E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.55|P-value:3.38E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:3.87|P-value:6.42E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.13|P-value:8.69E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.42|P-value:3.24E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.16|P-value:8.02E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.54|P-value:2.34E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.70|P-value:1.25E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.32|P-value:5.10E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:-3.10|P-value:9.63E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:-3.43|P-value:3.06E-4 ID:SGTC_1650|Compound:st011916|FD-Score:4.45|P-value:5.27E-6 ID:SGTC_1666|Compound:st014829|FD-Score:-3.59|P-value:1.68E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.40|P-value:3.83E-4 ID:SGTC_1977|Compound:st070720|FD-Score:-3.38|P-value:3.73E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-4.40|P-value:5.71E-6 ID:SGTC_2442|Compound:5158906|FD-Score:3.55|P-value:2.22E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.53|P-value:2.13E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.18|P-value:7.50E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-4.60|P-value:2.20E-6 ID:SGTC_2921|Compound:7974240|FD-Score:-4.18|P-value:1.53E-5 ID:SGTC_2927|Compound:9011802|FD-Score:3.61|P-value:1.76E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-4.33|P-value:7.64E-6 ID:SGTC_2951|Compound:9072950|FD-Score:5.60|P-value:1.46E-8 ID:SGTC_2959|Compound:9079155|FD-Score:-4.29|P-value:9.54E-6 ID:SGTC_3070|Compound:9117005|FD-Score:3.31|P-value:5.28E-4

Top fitness defect scores for YGR010W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2951 9072950 5.60 58.1 µM 1.46E-8 ERG2 8 1.08E-8
2 SGTC_363 0455-0021 4.55 3.1 µM 3.38E-6 azole & statin 47 2.72E-6
3 SGTC_1650 st011916 4.45 45.8 µM 5.27E-6 6 4.27E-6
4 SGTC_375 3970-0961 3.87 9.3 µM 6.42E-5 tubulin folding & SWR complex 20 5.42E-5
5 SGTC_970 1315-0089 3.70 19.5 µM 1.25E-4 RSC & ERG11 29 1.07E-4
6 SGTC_2927 9011802 3.61 47.9 µM 1.76E-4 37 1.51E-4
7 SGTC_2442 5158906 3.55 48.5 µM 2.22E-4 32 1.91E-4
8 SGTC_928 2764-0428 3.54 58.7 µM 2.34E-4 cell wall 75 2.02E-4
9 SGTC_1909 st060837 3.40 51.5 µM 3.83E-4 77 3.32E-4
10 SGTC_971 1315-0384 3.32 26.7 µM 5.10E-4 cell wall signaling 53 4.45E-4
11 SGTC_3070 9117005 3.31 49.5 µM 5.28E-4 11 4.61E-4
12 SGTC_736 0958-0254 3.11 92.6 µM 0.00105 Golgi 71 9.25E-4
13 SGTC_2097 5376186 3.07 200.0 µM 0.00120 64 0.00106
14 SGTC_1893 st059353 3.07 36.1 µM 0.00121 61 0.00107
15 SGTC_3316 9136639 3.04 10.6 µM 0.00133 49 0.00118
16 SGTC_46 0329-0187a 3.04 2.2 µM 0.00133 132 0.00118
17 SGTC_1111 tnp00062 3.03 510.7 nM 0.00136 32 0.00120
18 SGTC_721 1187-1332 3.01 279.0 µM 0.00149 cell wall signaling 41 0.00132
19 SGTC_966 1300-0360 2.99 30.2 µM 0.00156 heme requiring 68 0.00138
20 SGTC_1640 st009078 2.99 66.4 µM 0.00158 43 0.00140

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 3.63E-16 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.107 6.14E-10 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 3.15E-9 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.099 8.95E-9 YGR199W PMT6 hom Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases
0.093 7.22E-8 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.091 1.37E-7 YNL108C_p YNL108C_p hom Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication
0.090 2.00E-7 YGL253W HXK2 hom Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication
0.090 2.02E-7 YPR110C RPC40 het RNA polymerase subunit AC40, common to RNA polymerase I and III
0.090 2.08E-7 YKR034W DAL80 hom Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
0.088 3.20E-7 YBR016W YBR016W hom Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication
0.084 9.99E-7 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.083 1.42E-6 YDR374C_p YDR374C_p hom Putative protein of unknown function
0.083 1.43E-6 YBR086C IST2 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
0.082 2.20E-6 YIR042C_p YIR042C_p hom Putative protein of unknown function; YIR042C is a non-essential gene
0.080 4.14E-6 YDL006W PTC1 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation