YGR015C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR015C / YGR015C

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:3.34|P-value:6.94E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:4.51|P-value:7.80E-6 ID:SGTC_857|Compound:0438-0306|FD-Score:3.92|P-value:8.53E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.93|P-value:7.11E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:4.02|P-value:5.86E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:3.52|P-value:3.71E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.65|P-value:2.35E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.38|P-value:6.11E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:4.09|P-value:4.49E-5 ID:SGTC_1605|Compound:st000082|FD-Score:3.61|P-value:2.78E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-3.97|P-value:5.94E-5 ID:SGTC_1861|Compound:st057647|FD-Score:-3.26|P-value:7.90E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-3.21|P-value:9.13E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.85|P-value:9.48E-5 ID:SGTC_1933|Compound:st074711|FD-Score:3.87|P-value:1.05E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.45|P-value:4.76E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.81|P-value:1.30E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-14.30|P-value:9.21E-44 ID:SGTC_2793|Compound:7325131|FD-Score:4.56|P-value:6.30E-6 ID:SGTC_2804|Compound:7954240|FD-Score:3.72|P-value:1.81E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.24|P-value:9.76E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.35|P-value:6.79E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-4.93|P-value:9.18E-7 ID:SGTC_2998|Compound:9066762|FD-Score:-4.17|P-value:2.66E-5 ID:SGTC_3099|Compound:9120367|FD-Score:-3.29|P-value:7.06E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-4.25|P-value:1.95E-5 ID:SGTC_3346|Compound:9158254|FD-Score:-3.53|P-value:3.08E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.34|P-value:6.94E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:4.51|P-value:7.80E-6 ID:SGTC_857|Compound:0438-0306|FD-Score:3.92|P-value:8.53E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.93|P-value:7.11E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:4.02|P-value:5.86E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:3.52|P-value:3.71E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.65|P-value:2.35E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.38|P-value:6.11E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:4.09|P-value:4.49E-5 ID:SGTC_1605|Compound:st000082|FD-Score:3.61|P-value:2.78E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-3.97|P-value:5.94E-5 ID:SGTC_1861|Compound:st057647|FD-Score:-3.26|P-value:7.90E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-3.21|P-value:9.13E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.85|P-value:9.48E-5 ID:SGTC_1933|Compound:st074711|FD-Score:3.87|P-value:1.05E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.45|P-value:4.76E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.81|P-value:1.30E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-14.30|P-value:9.21E-44 ID:SGTC_2793|Compound:7325131|FD-Score:4.56|P-value:6.30E-6 ID:SGTC_2804|Compound:7954240|FD-Score:3.72|P-value:1.81E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.24|P-value:9.76E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.35|P-value:6.79E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-4.93|P-value:9.18E-7 ID:SGTC_2998|Compound:9066762|FD-Score:-4.17|P-value:2.66E-5 ID:SGTC_3099|Compound:9120367|FD-Score:-3.29|P-value:7.06E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-4.25|P-value:1.95E-5 ID:SGTC_3346|Compound:9158254|FD-Score:-3.53|P-value:3.08E-4

Top fitness defect scores for YGR015C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2793 7325131 4.56 81.8 µM 6.30E-6 10 2.61E-6
2 SGTC_849 0386-0493 4.51 241.0 µM 7.80E-6 7 3.28E-6
3 SGTC_1512 0259-0544 4.09 12.2 µM 4.49E-5 11 2.17E-5
4 SGTC_877 0771-0151 4.02 33.1 µM 5.86E-5 14 2.89E-5
5 SGTC_857 0438-0306 3.92 1.4 µM 8.53E-5 copper-dependent oxidative stress 13 4.34E-5
6 SGTC_1933 st074711 3.87 15.9 µM 1.05E-4 43 5.41E-5
7 SGTC_2585 alliin 3.81 100.0 µM 1.30E-4 28 6.83E-5
8 SGTC_2804 7954240 3.72 19.5 µM 1.81E-4 43 9.79E-5
9 SGTC_1017 4239-0030 3.65 168.0 µM 2.35E-4 38 1.29E-4
10 SGTC_1605 st000082 3.61 49.1 µM 2.78E-4 60S ribosome export 26 1.55E-4
11 SGTC_982 1491-0518 3.52 27.5 µM 3.71E-4 25 2.12E-4
12 SGTC_2097 5376186 3.45 200.0 µM 4.76E-4 36 2.77E-4
13 SGTC_1153 4055-0057 3.38 267.0 µM 6.11E-4 51 3.63E-4
14 SGTC_2934 9036370 3.35 36.9 µM 6.79E-4 52 4.07E-4
15 SGTC_61 0978-8327 3.34 98.6 µM 6.94E-4 ergosterol biosynthesis 50 4.16E-4
16 SGTC_2805 7950783 3.24 58.4 µM 9.76E-4 54 6.02E-4
17 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 3.21 100.0 µM 0.00105 60S ribosome export 52 6.53E-4
18 SGTC_420 mitomycin C 3.19 81.9 mM 0.00115 44 7.21E-4
19 SGTC_1880 MG-132 3.19 525.0 µM 0.00115 38 7.22E-4
20 SGTC_3217 9129673 3.18 49.5 µM 0.00118 79 7.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.396 2.09E-126 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.333 1.07E-87 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.331 1.13E-86 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.268 2.62E-56 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.258 2.61E-52 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.247 8.03E-48 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.232 3.59E-42 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.225 7.02E-40 YGL144C ROG1 hom Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
0.222 1.24E-38 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.220 4.47E-38 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.218 1.55E-37 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.215 2.93E-36 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.199 2.82E-31 YPL100W ATG21 hom Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
0.198 7.66E-31 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.188 5.73E-28 YAL004W_d YAL004W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C