YGR018C_p

Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR018C / YGR018C

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-5.78|P-value:8.35E-12 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.10|P-value:1.51E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.05|P-value:1.87E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.00|P-value:2.67E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:2.74|P-value:7.77E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.65|P-value:1.05E-5 ID:SGTC_446|Compound:go6976|FD-Score:-7.70|P-value:1.64E-19 ID:SGTC_455|Compound:paf C-16|FD-Score:2.85|P-value:5.04E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.26|P-value:7.24E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:3.41|P-value:4.07E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:3.67|P-value:1.12E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.12|P-value:1.20E-9 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.78|P-value:5.93E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.26|P-value:8.45E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:2.69|P-value:9.74E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-3.02|P-value:2.12E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.50|P-value:2.57E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:2.77|P-value:7.00E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.93|P-value:3.05E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.87|P-value:3.97E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:2.69|P-value:9.68E-4 ID:SGTC_1802|Compound:st050112|FD-Score:-3.16|P-value:1.11E-4 ID:SGTC_1856|Compound:st057054|FD-Score:2.80|P-value:6.09E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:2.95|P-value:3.27E-4 ID:SGTC_1920|Compound:st075728|FD-Score:2.74|P-value:7.76E-4 ID:SGTC_2002|Compound:4023503|FD-Score:5.61|P-value:4.04E-11 ID:SGTC_2008|Compound:4012253|FD-Score:-4.80|P-value:1.12E-8 ID:SGTC_2010|Compound:4012422|FD-Score:2.71|P-value:8.85E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-2.66|P-value:9.50E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.24|P-value:9.07E-5 ID:SGTC_2166|Compound:5933061|FD-Score:2.75|P-value:7.62E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.00|P-value:2.68E-4 ID:SGTC_2393|Compound:9031399|FD-Score:2.81|P-value:5.88E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-4.19|P-value:5.16E-7 ID:SGTC_2434|Compound:5670830|FD-Score:-3.84|P-value:3.85E-6 ID:SGTC_2437|Compound:5741531|FD-Score:5.34|P-value:3.29E-10 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-2.77|P-value:6.01E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.93|P-value:2.73E-6 ID:SGTC_2819|Compound:7996655|FD-Score:-2.87|P-value:3.93E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-3.79|P-value:4.92E-6 ID:SGTC_2900|Compound:5328528|FD-Score:-3.94|P-value:2.20E-6 ID:SGTC_2908|Compound:7930301|FD-Score:-3.15|P-value:1.17E-4 ID:SGTC_2924|Compound:9010168|FD-Score:2.87|P-value:4.64E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.57|P-value:1.57E-5 ID:SGTC_3146|Compound:9095609|FD-Score:-2.84|P-value:4.51E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.42|P-value:3.28E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-2.68|P-value:8.83E-4 ID:SGTC_3223|Compound:9129970|FD-Score:-4.00|P-value:1.53E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:-5.78|P-value:8.35E-12 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.10|P-value:1.51E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.05|P-value:1.87E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.00|P-value:2.67E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:2.74|P-value:7.77E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.65|P-value:1.05E-5 ID:SGTC_446|Compound:go6976|FD-Score:-7.70|P-value:1.64E-19 ID:SGTC_455|Compound:paf C-16|FD-Score:2.85|P-value:5.04E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.26|P-value:7.24E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:3.41|P-value:4.07E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:3.67|P-value:1.12E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.12|P-value:1.20E-9 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.78|P-value:5.93E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.26|P-value:8.45E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:2.69|P-value:9.74E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-3.02|P-value:2.12E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.50|P-value:2.57E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:2.77|P-value:7.00E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.93|P-value:3.05E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.87|P-value:3.97E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:2.69|P-value:9.68E-4 ID:SGTC_1802|Compound:st050112|FD-Score:-3.16|P-value:1.11E-4 ID:SGTC_1856|Compound:st057054|FD-Score:2.80|P-value:6.09E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:2.95|P-value:3.27E-4 ID:SGTC_1920|Compound:st075728|FD-Score:2.74|P-value:7.76E-4 ID:SGTC_2002|Compound:4023503|FD-Score:5.61|P-value:4.04E-11 ID:SGTC_2008|Compound:4012253|FD-Score:-4.80|P-value:1.12E-8 ID:SGTC_2010|Compound:4012422|FD-Score:2.71|P-value:8.85E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-2.66|P-value:9.50E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.24|P-value:9.07E-5 ID:SGTC_2166|Compound:5933061|FD-Score:2.75|P-value:7.62E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.00|P-value:2.68E-4 ID:SGTC_2393|Compound:9031399|FD-Score:2.81|P-value:5.88E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-4.19|P-value:5.16E-7 ID:SGTC_2434|Compound:5670830|FD-Score:-3.84|P-value:3.85E-6 ID:SGTC_2437|Compound:5741531|FD-Score:5.34|P-value:3.29E-10 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-2.77|P-value:6.01E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.93|P-value:2.73E-6 ID:SGTC_2819|Compound:7996655|FD-Score:-2.87|P-value:3.93E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-3.79|P-value:4.92E-6 ID:SGTC_2900|Compound:5328528|FD-Score:-3.94|P-value:2.20E-6 ID:SGTC_2908|Compound:7930301|FD-Score:-3.15|P-value:1.17E-4 ID:SGTC_2924|Compound:9010168|FD-Score:2.87|P-value:4.64E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.57|P-value:1.57E-5 ID:SGTC_3146|Compound:9095609|FD-Score:-2.84|P-value:4.51E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.42|P-value:3.28E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-2.68|P-value:8.83E-4 ID:SGTC_3223|Compound:9129970|FD-Score:-4.00|P-value:1.53E-6

Top fitness defect scores for YGR018C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2002 4023503 5.61 131.0 µM 4.04E-11 mitochondrial processes 9 9.84E-9
2 SGTC_2437 5741531 5.34 144.2 µM 3.29E-10 15 4.75E-8
3 SGTC_2685 mycophenolic acid 3.93 18.9 µM 2.73E-6 RNA pol III & RNase P/MRP 4 4.20E-5
4 SGTC_621 3584-0052 3.67 32.1 µM 1.12E-5 30 1.22E-4
5 SGTC_1180 1193-0155 3.50 285.0 µM 2.57E-5 24 2.29E-4
6 SGTC_620 0109-0052 3.41 432.0 µM 4.07E-5 34 3.24E-4
7 SGTC_895 0964-0006 3.26 13.7 µM 8.45E-5 36 5.64E-4
8 SGTC_2164 5685496 3.24 200.0 µM 9.07E-5 39 5.95E-4
9 SGTC_63 0099-0242 3.00 26.7 µM 2.67E-4 mitochondrial stress 154 0.00135
10 SGTC_2180 6301957 3.00 200.0 µM 2.68E-4 RSC complex & mRNA processing 25 0.00136
11 SGTC_1876 myriocin 2.95 605.0 nM 3.27E-4 75 0.00158
12 SGTC_2924 9010168 2.87 62.8 µM 4.64E-4 cell wall signaling 95 0.00206
13 SGTC_455 paf C-16 2.85 10.0 µM 5.04E-4 80 0.00219
14 SGTC_2393 9031399 2.81 185.9 µM 5.88E-4 RNA processing & uracil transport 90 0.00246
15 SGTC_1856 st057054 2.80 55.7 µM 6.09E-4 74 0.00253
16 SGTC_1184 1269-1718 2.77 139.0 µM 7.00E-4 75 0.00281
17 SGTC_2166 5933061 2.75 31.5 µM 7.62E-4 tubulin folding & SWR complex 114 0.00300
18 SGTC_1920 st075728 2.74 45.7 µM 7.76E-4 100 0.00304
19 SGTC_162 k030-0015 2.74 37.8 µM 7.77E-4 iron homeostasis 65 0.00305
20 SGTC_2010 4012422 2.71 159.0 µM 8.85E-4 100 0.00337

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.279 3.85E-61 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.242 8.98E-46 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.198 4.28E-31 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.189 3.34E-28 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.184 5.00E-27 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.178 3.32E-25 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.169 6.26E-23 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.158 4.69E-20 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.157 5.93E-20 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.144 5.07E-17 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.140 4.21E-16 YLR440C SEC39 het Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
0.138 1.07E-15 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.138 1.11E-15 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.137 1.38E-15 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.136 2.65E-15 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress