YGR022C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR022C / YGR022C

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:3.06|P-value:2.54E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.20|P-value:1.37E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:2.89|P-value:5.01E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.13|P-value:2.34E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.06|P-value:3.12E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.01|P-value:3.03E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.01|P-value:3.09E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.07|P-value:2.94E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:2.77|P-value:7.91E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:2.73|P-value:9.51E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:2.84|P-value:6.04E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.91|P-value:5.73E-6 ID:SGTC_1430|Compound:4049-0248|FD-Score:2.75|P-value:8.66E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-4.11|P-value:2.03E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-8.28|P-value:6.37E-21 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.82|P-value:9.08E-15 ID:SGTC_1515|Compound:3460-0031|FD-Score:-2.87|P-value:6.70E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-2.87|P-value:6.77E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.00|P-value:3.23E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.08|P-value:2.85E-4 ID:SGTC_1819|Compound:st053448|FD-Score:2.77|P-value:7.95E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.33|P-value:7.78E-5 ID:SGTC_2180|Compound:6301957|FD-Score:2.76|P-value:8.49E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.53|P-value:3.78E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.34|P-value:9.29E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.27|P-value:1.01E-4 ID:SGTC_2349|Compound:9023730|FD-Score:2.96|P-value:3.74E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:2.92|P-value:4.39E-4 ID:SGTC_2438|Compound:5259590|FD-Score:2.89|P-value:4.94E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.49|P-value:1.76E-7 ID:SGTC_2819|Compound:7996655|FD-Score:-4.27|P-value:8.58E-7 ID:SGTC_2821|Compound:7996764|FD-Score:2.83|P-value:6.32E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-2.80|P-value:8.83E-4 ID:SGTC_3158|Compound:9100007|FD-Score:2.79|P-value:7.56E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.06|P-value:2.54E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.20|P-value:1.37E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:2.89|P-value:5.01E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.13|P-value:2.34E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.06|P-value:3.12E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.01|P-value:3.03E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.01|P-value:3.09E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.07|P-value:2.94E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:2.77|P-value:7.91E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:2.73|P-value:9.51E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:2.84|P-value:6.04E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.91|P-value:5.73E-6 ID:SGTC_1430|Compound:4049-0248|FD-Score:2.75|P-value:8.66E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-4.11|P-value:2.03E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-8.28|P-value:6.37E-21 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.82|P-value:9.08E-15 ID:SGTC_1515|Compound:3460-0031|FD-Score:-2.87|P-value:6.70E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-2.87|P-value:6.77E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.00|P-value:3.23E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.08|P-value:2.85E-4 ID:SGTC_1819|Compound:st053448|FD-Score:2.77|P-value:7.95E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.33|P-value:7.78E-5 ID:SGTC_2180|Compound:6301957|FD-Score:2.76|P-value:8.49E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.53|P-value:3.78E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.34|P-value:9.29E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.27|P-value:1.01E-4 ID:SGTC_2349|Compound:9023730|FD-Score:2.96|P-value:3.74E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:2.92|P-value:4.39E-4 ID:SGTC_2438|Compound:5259590|FD-Score:2.89|P-value:4.94E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.49|P-value:1.76E-7 ID:SGTC_2819|Compound:7996655|FD-Score:-4.27|P-value:8.58E-7 ID:SGTC_2821|Compound:7996764|FD-Score:2.83|P-value:6.32E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-2.80|P-value:8.83E-4 ID:SGTC_3158|Compound:9100007|FD-Score:2.79|P-value:7.56E-4

Top fitness defect scores for YGR022C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2802 7925815 4.49 54.5 µM 1.76E-7 29 3.58E-6
2 SGTC_2035 5154463 3.33 94.6 µM 7.78E-5 34 4.39E-4
3 SGTC_2344 7990960 3.27 77.0 µM 1.01E-4 50 5.42E-4
4 SGTC_99 0109-0120 3.20 622.8 µM 1.37E-4 39 6.87E-4
5 SGTC_63 0099-0242 3.06 26.7 µM 2.54E-4 mitochondrial stress 149 0.00112
6 SGTC_300 r073-0011 3.01 5.0 µM 3.03E-4 58 0.00129
7 SGTC_534 k292-0788 3.01 63.4 µM 3.09E-4 mitochondrial processes 65 0.00131
8 SGTC_1726 st035556 3.00 14.6 µM 3.23E-4 92 0.00136
9 SGTC_2349 9023730 2.96 187.1 µM 3.74E-4 84 0.00153
10 SGTC_2419 paclitaxel 2.92 166.5 µM 4.39E-4 118 0.00173
11 SGTC_2438 5259590 2.89 200.0 µM 4.94E-4 55 0.00190
12 SGTC_181 1447-1644 2.89 8.1 µM 5.01E-4 endomembrane recycling 81 0.00192
13 SGTC_1411 3909-8223 2.84 150.0 µM 6.04E-4 43 0.00223
14 SGTC_2821 7996764 2.83 71.4 µM 6.32E-4 120 0.00231
15 SGTC_3158 9100007 2.79 49.5 µM 7.56E-4 68 0.00266
16 SGTC_1233 0325-0408 2.77 14.2 µM 7.91E-4 76 0.00276
17 SGTC_1819 st053448 2.77 58.6 µM 7.95E-4 amide catabolism 83 0.00277
18 SGTC_2180 6301957 2.76 200.0 µM 8.49E-4 RSC complex & mRNA processing 40 0.00292
19 SGTC_1430 4049-0248 2.75 69.1 µM 8.66E-4 88 0.00297
20 SGTC_1234 0326-0494 2.73 15.5 µM 9.51E-4 69 0.00320

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.523 7.34E-235 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.511 1.45E-221 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.486 1.91E-197 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.461 1.88E-176 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.435 1.70E-154 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.404 1.21E-131 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.399 2.58E-128 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.398 1.33E-127 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.396 2.50E-126 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.387 4.61E-120 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.375 2.94E-112 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.360 4.92E-103 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.356 1.30E-100 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.355 1.88E-100 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.353 5.53E-99 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension