YGR025W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR025W / YGR025W

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-3.09|P-value:2.06E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-6.94|P-value:1.03E-15 ID:SGTC_250|Compound:brefeldin a|FD-Score:-2.73|P-value:8.91E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:2.99|P-value:3.17E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.04|P-value:2.61E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.96|P-value:3.52E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.21|P-value:1.21E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.78|P-value:7.88E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.67|P-value:4.58E-11 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.62|P-value:1.75E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.33|P-value:7.11E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.50|P-value:3.13E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.78|P-value:7.75E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.08|P-value:2.19E-4 ID:SGTC_1673|Compound:st016611|FD-Score:2.92|P-value:4.25E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.57|P-value:2.21E-5 ID:SGTC_1906|Compound:st060206|FD-Score:2.85|P-value:5.57E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.47|P-value:3.70E-5 ID:SGTC_2046|Compound:4110841|FD-Score:2.75|P-value:8.37E-4 ID:SGTC_2297|Compound:7971671|FD-Score:2.97|P-value:3.38E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-3.21|P-value:1.23E-4 ID:SGTC_2301|Compound:7769476|FD-Score:2.93|P-value:4.05E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-2.75|P-value:8.53E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.01|P-value:2.20E-6 ID:SGTC_2585|Compound:alliin|FD-Score:2.74|P-value:8.78E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.95|P-value:3.18E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-3.04|P-value:2.57E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-2.80|P-value:6.80E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.07|P-value:2.24E-4 ID:SGTC_2989|Compound:9073649|FD-Score:2.91|P-value:4.44E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.22|P-value:1.17E-4 ID:SGTC_3174|Compound:9107204|FD-Score:2.79|P-value:7.06E-4 ID:SGTC_3209|Compound:9113616|FD-Score:2.96|P-value:3.57E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.09|P-value:2.06E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-6.94|P-value:1.03E-15 ID:SGTC_250|Compound:brefeldin a|FD-Score:-2.73|P-value:8.91E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:2.99|P-value:3.17E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.04|P-value:2.61E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.96|P-value:3.52E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.21|P-value:1.21E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.78|P-value:7.88E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.67|P-value:4.58E-11 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.62|P-value:1.75E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.33|P-value:7.11E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.50|P-value:3.13E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.78|P-value:7.75E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.08|P-value:2.19E-4 ID:SGTC_1673|Compound:st016611|FD-Score:2.92|P-value:4.25E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.57|P-value:2.21E-5 ID:SGTC_1906|Compound:st060206|FD-Score:2.85|P-value:5.57E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.47|P-value:3.70E-5 ID:SGTC_2046|Compound:4110841|FD-Score:2.75|P-value:8.37E-4 ID:SGTC_2297|Compound:7971671|FD-Score:2.97|P-value:3.38E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-3.21|P-value:1.23E-4 ID:SGTC_2301|Compound:7769476|FD-Score:2.93|P-value:4.05E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-2.75|P-value:8.53E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.01|P-value:2.20E-6 ID:SGTC_2585|Compound:alliin|FD-Score:2.74|P-value:8.78E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.95|P-value:3.18E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-3.04|P-value:2.57E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-2.80|P-value:6.80E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.07|P-value:2.24E-4 ID:SGTC_2989|Compound:9073649|FD-Score:2.91|P-value:4.44E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.22|P-value:1.17E-4 ID:SGTC_3174|Compound:9107204|FD-Score:2.79|P-value:7.06E-4 ID:SGTC_3209|Compound:9113616|FD-Score:2.96|P-value:3.57E-4

Top fitness defect scores for YGR025W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2419 paclitaxel 4.01 166.5 µM 2.20E-6 38 2.98E-5
2 SGTC_1008 4106-0037 3.78 6.0 µM 7.88E-6 PDR1 24 7.99E-5
3 SGTC_1239 0337-0584 3.62 35.4 µM 1.75E-5 unfolded protein response 70 1.48E-4
4 SGTC_1889 st059080 3.57 5.2 µM 2.21E-5 29 1.78E-4
5 SGTC_1330 1469-0054 3.50 61.8 µM 3.13E-5 iron homeostasis 31 2.33E-4
6 SGTC_1251 0490-5699 3.33 265.0 µM 7.11E-5 65 4.40E-4
7 SGTC_3165 9101544 3.22 49.5 µM 1.17E-4 28 6.46E-4
8 SGTC_996 3970-0799 3.21 1.8 µM 1.21E-4 136 6.67E-4
9 SGTC_300 r073-0011 2.99 5.0 µM 3.17E-4 63 0.00141
10 SGTC_2297 7971671 2.97 152.3 µM 3.38E-4 RNA processing & uracil transport 66 0.00148
11 SGTC_3209 9113616 2.96 49.5 µM 3.57E-4 84 0.00155
12 SGTC_2301 7769476 2.93 200.0 µM 4.05E-4 57 0.00170
13 SGTC_1673 st016611 2.92 27.3 µM 4.25E-4 103 0.00177
14 SGTC_2989 9073649 2.91 71.4 µM 4.44E-4 104 0.00183
15 SGTC_1906 st060206 2.85 94.7 µM 5.57E-4 80 0.00219
16 SGTC_3174 9107204 2.79 49.5 µM 7.06E-4 ERG2 95 0.00263
17 SGTC_2046 4110841 2.75 106.0 µM 8.37E-4 iron homeostasis 77 0.00300
18 SGTC_2585 alliin 2.74 100.0 µM 8.78E-4 110 0.00312
19 SGTC_2393 9031399 2.68 185.9 µM 0.00107 RNA processing & uracil transport 113 0.00364
20 SGTC_2048 5246248 2.68 200.0 µM 0.00110 50 0.00371

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.314 7.99E-78 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.308 7.73E-75 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.301 5.78E-71 YML084W_d YML084W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.259 1.29E-52 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.244 1.21E-46 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.238 3.58E-44 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.237 7.84E-44 YNL042W BOP3 hom Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury
0.231 8.05E-42 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.226 3.20E-40 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.222 1.80E-38 YDR242W AMD2 hom Putative amidase
0.220 4.09E-38 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.218 1.74E-37 YGR169C PUS6 hom tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability
0.218 2.77E-37 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.217 3.55E-37 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.214 3.64E-36 YPL012W RRP12 het Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats