YGR026W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR026W / YGR026W

Click on Significant Values for Screen Details ID:SGTC_93|Compound:0109-0045|FD-Score:-3.96|P-value:2.80E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.34|P-value:6.77E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:3.81|P-value:6.85E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.97|P-value:2.67E-5 ID:SGTC_512|Compound:prima-1|FD-Score:-5.33|P-value:3.01E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.42|P-value:2.41E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.30|P-value:4.78E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.21|P-value:6.64E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.88|P-value:5.23E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.39|P-value:2.71E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.24|P-value:5.93E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.13|P-value:8.82E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.10|P-value:7.81E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.10|P-value:9.91E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.03|P-value:9.81E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.20|P-value:5.42E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.42|P-value:3.08E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.66|P-value:1.26E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.85|P-value:5.81E-5 ID:SGTC_1638|Compound:st008370|FD-Score:-4.45|P-value:2.94E-6 ID:SGTC_1712|Compound:st032288|FD-Score:-4.16|P-value:1.14E-5 ID:SGTC_1743|Compound:st037606|FD-Score:3.23|P-value:6.22E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.37|P-value:3.72E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.40|P-value:2.64E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.21|P-value:5.32E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.21|P-value:6.60E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-4.75|P-value:6.71E-7 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.80|P-value:7.13E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.59|P-value:2.16E-6 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.69|P-value:1.26E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:3.45|P-value:2.86E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.34|P-value:3.34E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.06|P-value:8.81E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.98|P-value:3.38E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:-3.96|P-value:2.80E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.34|P-value:6.77E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:3.81|P-value:6.85E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.97|P-value:2.67E-5 ID:SGTC_512|Compound:prima-1|FD-Score:-5.33|P-value:3.01E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.42|P-value:2.41E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.30|P-value:4.78E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.21|P-value:6.64E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.88|P-value:5.23E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.39|P-value:2.71E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.24|P-value:5.93E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.13|P-value:8.82E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.10|P-value:7.81E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.10|P-value:9.91E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.03|P-value:9.81E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.20|P-value:5.42E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.42|P-value:3.08E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.66|P-value:1.26E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.85|P-value:5.81E-5 ID:SGTC_1638|Compound:st008370|FD-Score:-4.45|P-value:2.94E-6 ID:SGTC_1712|Compound:st032288|FD-Score:-4.16|P-value:1.14E-5 ID:SGTC_1743|Compound:st037606|FD-Score:3.23|P-value:6.22E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.37|P-value:3.72E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.40|P-value:2.64E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.21|P-value:5.32E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.21|P-value:6.60E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-4.75|P-value:6.71E-7 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.80|P-value:7.13E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.59|P-value:2.16E-6 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.69|P-value:1.26E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:3.45|P-value:2.86E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.34|P-value:3.34E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.06|P-value:8.81E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.98|P-value:3.38E-5

Top fitness defect scores for YGR026W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2755 lomerizine 4.69 42.7 µM 1.26E-6 15 1.33E-6
2 SGTC_2546 rhodinyl acetate 4.59 100.0 µM 2.16E-6 7 2.27E-6
3 SGTC_143 4032-1194 4.34 15.7 µM 6.77E-6 48 7.03E-6
4 SGTC_3206 9114350 3.98 49.5 µM 3.38E-5 19 3.45E-5
5 SGTC_823 0417-1665 3.88 178.0 µM 5.23E-5 39 5.31E-5
6 SGTC_1632 st005650 3.85 90.0 µM 5.81E-5 33 5.90E-5
7 SGTC_383 2324-0395 3.81 7.4 µM 6.85E-5 azole & statin 37 6.94E-5
8 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 3.80 100.0 µM 7.13E-5 23 7.22E-5
9 SGTC_1548 st061468 3.66 90.8 µM 1.26E-4 12 1.27E-4
10 SGTC_2756 carbadox 3.45 75.1 µM 2.86E-4 75 2.85E-4
11 SGTC_1546 5-methoxyflavanone 3.42 78.7 µM 3.08E-4 19 3.08E-4
12 SGTC_1940 st075990 3.37 51.1 µM 3.72E-4 60S ribosome export 42 3.71E-4
13 SGTC_819 1013-0258 3.30 27.7 µM 4.78E-4 60 4.75E-4
14 SGTC_864 0469-0573 3.24 172.0 µM 5.93E-4 43 5.88E-4
15 SGTC_1743 st037606 3.23 46.4 µM 6.22E-4 48 6.16E-4
16 SGTC_2419 paclitaxel 3.21 166.5 µM 6.60E-4 88 6.55E-4
17 SGTC_821 1114-0266 3.21 29.2 µM 6.64E-4 48 6.58E-4
18 SGTC_960 1222-0186 3.13 7.7 µM 8.82E-4 65 8.72E-4
19 SGTC_1071 trifluoperazine 3.10 6.3 µM 9.91E-4 57 9.79E-4
20 SGTC_963 1269-2853 3.02 151.0 µM 0.00128 68 0.00127

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 4.19E-11 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.112 7.85E-11 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.108 3.71E-10 YPR048W TAH18 het Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance
0.106 7.98E-10 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.099 1.06E-8 YIL099W SGA1 hom Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
0.098 1.28E-8 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.091 1.35E-7 YNL024C_p YNL024C_p hom Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern
0.088 3.20E-7 YLR402W_d YLR402W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.088 3.57E-7 YGR039W_d YGR039W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
0.088 3.65E-7 YKR106W GEX2 hom Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway
0.086 6.80E-7 YKL075C_p YKL075C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin
0.085 7.30E-7 YOR304C-A_p YOR304C-A_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck
0.085 9.26E-7 YLR070C XYL2 hom Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect
0.085 9.36E-7 YMR251W GTO3 hom Omega class glutathione transferase; putative cytosolic localization
0.084 1.30E-6 YBL081W_p YBL081W_p hom Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport