HIPHOP chemogenomics database
YGR032W / GSC2 
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YGR032W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.310 | 1.33E-75 | YML052W | SUR7 | hom | Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants |
| 0.310 | 1.78E-75 | YML103C | NUP188 | hom | Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188 |
| 0.233 | 1.11E-42 | YLR288C | MEC3 | hom | DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 |
| 0.230 | 1.18E-41 | YLR401C | DUS3 | hom | Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress |
| 0.219 | 1.38E-37 | YNL106C | INP52 | hom | Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain |
| 0.217 | 3.45E-37 | YIL160C | POT1 | hom | 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids |
| 0.210 | 8.45E-35 | YBL036C | YBL036C | hom | Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS |
| 0.202 | 2.29E-32 | YLR267W_p | BOP2_p | hom | Protein of unknown function |
| 0.193 | 1.51E-29 | YFL063W_d | YFL063W_d | hom | Dubious open reading frame, based on available experimental and comparative sequence data |
| 0.191 | 7.24E-29 | YHR003C | YHR003C | hom | Protein of unknown function, localized to the mitochondrial outer membrane |
| 0.190 | 1.20E-28 | YKL179C | COY1 | hom | Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function |
| 0.189 | 2.15E-28 | YEL007W | MIT1 | hom | Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1 |
| 0.188 | 4.36E-28 | YBL015W | ACH1 | hom | Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth |
| 0.186 | 1.86E-27 | YOR050C_d | YOR050C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable |
| 0.185 | 2.50E-27 | YGL134W | PCL10 | hom | Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate |