YGR032W / GSC2

Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR032W / GSC2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.71|P-value:2.12E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.13|P-value:2.57E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.11|P-value:2.87E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:-2.83|P-value:8.40E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:2.95|P-value:5.64E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-3.01|P-value:4.26E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-2.91|P-value:6.27E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-2.81|P-value:9.24E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-2.99|P-value:4.65E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.78|P-value:7.89E-11 ID:SGTC_942|Compound:3253-1115|FD-Score:2.88|P-value:7.40E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.19|P-value:2.04E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.28|P-value:1.81E-12 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.15|P-value:2.58E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.30|P-value:1.33E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:-3.26|P-value:1.50E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.36|P-value:1.05E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.68|P-value:2.46E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-3.77|P-value:1.45E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.10|P-value:3.10E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-2.82|P-value:8.79E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.32|P-value:1.15E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-3.41|P-value:7.89E-5 ID:SGTC_1986|Compound:st071812|FD-Score:-3.35|P-value:1.04E-4 ID:SGTC_1987|Compound:st072290|FD-Score:-3.64|P-value:2.79E-5 ID:SGTC_2000|Compound:st075254|FD-Score:-4.70|P-value:9.81E-8 ID:SGTC_2052|Compound:5265182|FD-Score:-3.06|P-value:3.44E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-7.58|P-value:2.31E-17 ID:SGTC_2087|Compound:5276107|FD-Score:2.81|P-value:9.51E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-2.96|P-value:5.22E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.04|P-value:3.79E-4 ID:SGTC_2217|Compound:6934799|FD-Score:3.64|P-value:2.97E-5 ID:SGTC_2316|Compound:5844804|FD-Score:2.86|P-value:8.09E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.24|P-value:1.71E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.99|P-value:5.34E-15 ID:SGTC_2666|Compound:tannic acid|FD-Score:-4.95|P-value:2.08E-8 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.18|P-value:2.09E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.07|P-value:3.49E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-2.92|P-value:6.02E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.48|P-value:6.08E-5 ID:SGTC_2975|Compound:9084847|FD-Score:3.27|P-value:1.51E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.09|P-value:3.18E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-4.87|P-value:3.56E-8 ID:SGTC_3078|Compound:9116413|FD-Score:-2.79|P-value:9.88E-4 ID:SGTC_3080|Compound:9117754|FD-Score:2.92|P-value:6.45E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.38|P-value:9.20E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-2.91|P-value:6.29E-4 ID:SGTC_3160|Compound:9100216|FD-Score:4.16|P-value:2.15E-6 ID:SGTC_3165|Compound:9101544|FD-Score:2.85|P-value:8.40E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-3.59|P-value:3.54E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-2.92|P-value:5.99E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.38|P-value:9.31E-5 ID:SGTC_3343|Compound:9148379|FD-Score:2.84|P-value:8.49E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.71|P-value:2.12E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.13|P-value:2.57E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.11|P-value:2.87E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:-2.83|P-value:8.40E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:2.95|P-value:5.64E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-3.01|P-value:4.26E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-2.91|P-value:6.27E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-2.81|P-value:9.24E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-2.99|P-value:4.65E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.78|P-value:7.89E-11 ID:SGTC_942|Compound:3253-1115|FD-Score:2.88|P-value:7.40E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.19|P-value:2.04E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.28|P-value:1.81E-12 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.15|P-value:2.58E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.30|P-value:1.33E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:-3.26|P-value:1.50E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.36|P-value:1.05E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.68|P-value:2.46E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-3.77|P-value:1.45E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.10|P-value:3.10E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-2.82|P-value:8.79E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.32|P-value:1.15E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-3.41|P-value:7.89E-5 ID:SGTC_1986|Compound:st071812|FD-Score:-3.35|P-value:1.04E-4 ID:SGTC_1987|Compound:st072290|FD-Score:-3.64|P-value:2.79E-5 ID:SGTC_2000|Compound:st075254|FD-Score:-4.70|P-value:9.81E-8 ID:SGTC_2052|Compound:5265182|FD-Score:-3.06|P-value:3.44E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-7.58|P-value:2.31E-17 ID:SGTC_2087|Compound:5276107|FD-Score:2.81|P-value:9.51E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-2.96|P-value:5.22E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.04|P-value:3.79E-4 ID:SGTC_2217|Compound:6934799|FD-Score:3.64|P-value:2.97E-5 ID:SGTC_2316|Compound:5844804|FD-Score:2.86|P-value:8.09E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.24|P-value:1.71E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.99|P-value:5.34E-15 ID:SGTC_2666|Compound:tannic acid|FD-Score:-4.95|P-value:2.08E-8 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.18|P-value:2.09E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.07|P-value:3.49E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-2.92|P-value:6.02E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.48|P-value:6.08E-5 ID:SGTC_2975|Compound:9084847|FD-Score:3.27|P-value:1.51E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.09|P-value:3.18E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-4.87|P-value:3.56E-8 ID:SGTC_3078|Compound:9116413|FD-Score:-2.79|P-value:9.88E-4 ID:SGTC_3080|Compound:9117754|FD-Score:2.92|P-value:6.45E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.38|P-value:9.20E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-2.91|P-value:6.29E-4 ID:SGTC_3160|Compound:9100216|FD-Score:4.16|P-value:2.15E-6 ID:SGTC_3165|Compound:9101544|FD-Score:2.85|P-value:8.40E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-3.59|P-value:3.54E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-2.92|P-value:5.99E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.38|P-value:9.31E-5 ID:SGTC_3343|Compound:9148379|FD-Score:2.84|P-value:8.49E-4

Top fitness defect scores for YGR032W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 6.99 100.0 µM 5.34E-15 redox potentiating 129 1.33E-12
2 SGTC_3160 9100216 4.16 49.5 µM 2.15E-6 3 1.59E-5
3 SGTC_58 0957-0393 3.71 9.0 µM 2.12E-5 cell wall 400 1.05E-4
4 SGTC_1715 st032160 3.68 10.2 µM 2.46E-5 50 1.19E-4
5 SGTC_2217 6934799 3.64 96.1 µM 2.97E-5 TSC3-RPN4 11 1.39E-4
6 SGTC_2974 9094440 3.48 9.7 µM 6.08E-5 ergosterol biosynthesis 60 2.51E-4
7 SGTC_3324 9138759 3.38 60.8 µM 9.31E-5 33 3.57E-4
8 SGTC_1360 1598-0022 3.36 39.8 µM 1.05E-4 ERG2 54 3.94E-4
9 SGTC_1258 0671-0043 3.30 57.1 µM 1.33E-4 52 4.81E-4
10 SGTC_2975 9084847 3.27 53.7 µM 1.51E-4 56 5.32E-4
11 SGTC_2419 paclitaxel 3.24 166.5 µM 1.71E-4 85 5.92E-4
12 SGTC_1224 0823-0416 3.15 294.0 µM 2.58E-4 38 8.30E-4
13 SGTC_1725 st036284 3.10 20.6 µM 3.10E-4 66 9.67E-4
14 SGTC_2980 9014342 3.09 25.3 µM 3.18E-4 73 9.88E-4
15 SGTC_2757 clomiphene 3.07 4.2 µM 3.49E-4 fatty acid desaturase (OLE1) 90 0.00107
16 SGTC_299 1273-0059 2.95 1.4 µM 5.64E-4 62 0.00159
17 SGTC_3080 9117754 2.92 49.5 µM 6.45E-4 59 0.00178
18 SGTC_942 3253-1115 2.88 227.0 µM 7.40E-4 85 0.00199
19 SGTC_2316 5844804 2.86 197.4 µM 8.09E-4 113 0.00215
20 SGTC_3165 9101544 2.85 49.5 µM 8.40E-4 50 0.00221

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.310 1.33E-75 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.310 1.78E-75 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.233 1.11E-42 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.230 1.18E-41 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.219 1.38E-37 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.217 3.45E-37 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.210 8.45E-35 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.202 2.29E-32 YLR267W_p BOP2_p hom Protein of unknown function
0.193 1.51E-29 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.191 7.24E-29 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.190 1.20E-28 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.189 2.15E-28 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.188 4.36E-28 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.186 1.86E-27 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.185 2.50E-27 YGL134W PCL10 hom Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate