YGR035C_p

Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR035C / YGR035C

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:6.24|P-value:5.09E-12 ID:SGTC_43|Compound:0570-0105|FD-Score:3.64|P-value:3.57E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:4.04|P-value:5.24E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:3.63|P-value:3.75E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:3.02|P-value:5.06E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:2.89|P-value:8.28E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.08|P-value:1.57E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:6.25|P-value:4.99E-12 ID:SGTC_193|Compound:1273-0060|FD-Score:3.16|P-value:2.83E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:8.54|P-value:6.97E-21 ID:SGTC_216|Compound:k038-0035|FD-Score:5.53|P-value:8.62E-10 ID:SGTC_266|Compound:formosanin C|FD-Score:3.08|P-value:3.93E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:-2.89|P-value:8.08E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:2.99|P-value:5.54E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.31|P-value:1.31E-6 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.50|P-value:6.73E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:3.34|P-value:1.36E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:2.92|P-value:7.35E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:4.65|P-value:2.00E-7 ID:SGTC_996|Compound:3970-0799|FD-Score:12.70|P-value:6.36E-44 ID:SGTC_1003|Compound:4049-0218|FD-Score:2.92|P-value:7.36E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.21|P-value:2.32E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:-3.05|P-value:4.44E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:3.32|P-value:1.48E-4 ID:SGTC_1792|Compound:st045773|FD-Score:4.14|P-value:3.18E-6 ID:SGTC_1984|Compound:st072354|FD-Score:3.66|P-value:3.36E-5 ID:SGTC_2017|Compound:5132927|FD-Score:2.96|P-value:6.20E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.57|P-value:5.04E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-3.71|P-value:2.66E-5 ID:SGTC_2393|Compound:9031399|FD-Score:2.92|P-value:7.32E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.30|P-value:1.58E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.38|P-value:1.17E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.88|P-value:1.18E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:-2.96|P-value:6.21E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.36|P-value:1.23E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.46|P-value:8.02E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.76|P-value:2.14E-5 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.14|P-value:3.06E-4 ID:SGTC_2797|Compound:7859098|FD-Score:2.90|P-value:7.85E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.26|P-value:1.89E-4 ID:SGTC_2997|Compound:9067075|FD-Score:2.99|P-value:5.51E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-2.99|P-value:5.52E-4 ID:SGTC_3209|Compound:9113616|FD-Score:4.07|P-value:4.64E-6 ID:SGTC_3312|Compound:9133330|FD-Score:-4.18|P-value:2.69E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:6.24|P-value:5.09E-12 ID:SGTC_43|Compound:0570-0105|FD-Score:3.64|P-value:3.57E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:4.04|P-value:5.24E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:3.63|P-value:3.75E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:3.02|P-value:5.06E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:2.89|P-value:8.28E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.08|P-value:1.57E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:6.25|P-value:4.99E-12 ID:SGTC_193|Compound:1273-0060|FD-Score:3.16|P-value:2.83E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:8.54|P-value:6.97E-21 ID:SGTC_216|Compound:k038-0035|FD-Score:5.53|P-value:8.62E-10 ID:SGTC_266|Compound:formosanin C|FD-Score:3.08|P-value:3.93E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:-2.89|P-value:8.08E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:2.99|P-value:5.54E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.31|P-value:1.31E-6 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.50|P-value:6.73E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:3.34|P-value:1.36E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:2.92|P-value:7.35E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:4.65|P-value:2.00E-7 ID:SGTC_996|Compound:3970-0799|FD-Score:12.70|P-value:6.36E-44 ID:SGTC_1003|Compound:4049-0218|FD-Score:2.92|P-value:7.36E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.21|P-value:2.32E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:-3.05|P-value:4.44E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:3.32|P-value:1.48E-4 ID:SGTC_1792|Compound:st045773|FD-Score:4.14|P-value:3.18E-6 ID:SGTC_1984|Compound:st072354|FD-Score:3.66|P-value:3.36E-5 ID:SGTC_2017|Compound:5132927|FD-Score:2.96|P-value:6.20E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.57|P-value:5.04E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-3.71|P-value:2.66E-5 ID:SGTC_2393|Compound:9031399|FD-Score:2.92|P-value:7.32E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.30|P-value:1.58E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.38|P-value:1.17E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.88|P-value:1.18E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:-2.96|P-value:6.21E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.36|P-value:1.23E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.46|P-value:8.02E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.76|P-value:2.14E-5 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.14|P-value:3.06E-4 ID:SGTC_2797|Compound:7859098|FD-Score:2.90|P-value:7.85E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.26|P-value:1.89E-4 ID:SGTC_2997|Compound:9067075|FD-Score:2.99|P-value:5.51E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-2.99|P-value:5.52E-4 ID:SGTC_3209|Compound:9113616|FD-Score:4.07|P-value:4.64E-6 ID:SGTC_3312|Compound:9133330|FD-Score:-4.18|P-value:2.69E-6

Top fitness defect scores for YGR035C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 12.70 1.8 µM 6.36E-44 8 2.59E-37
2 SGTC_200 k038-0079 8.54 37.5 µM 6.97E-21 ubiquinone biosynthesis & proteasome 14 6.98E-18
3 SGTC_158 k038-0087 6.25 26.4 µM 4.99E-12 ubiquinone biosynthesis & proteasome 63 2.10E-10
4 SGTC_36 0335-0881 6.24 14.2 µM 5.09E-12 ubiquinone biosynthesis & proteasome 60 2.13E-10
5 SGTC_216 k038-0035 5.53 28.4 µM 8.62E-10 ubiquinone biosynthesis & proteasome 30 1.64E-8
6 SGTC_145 3737-0113 5.08 38.4 µM 1.57E-8 DNA intercalators 41 1.91E-7
7 SGTC_825 1988-2224 4.65 89.6 µM 2.00E-7 cell wall signaling 24 1.65E-6
8 SGTC_457 grayanotoxin iii 4.31 135.0 µM 1.31E-6 51 8.09E-6
9 SGTC_1792 st045773 4.14 43.6 µM 3.18E-6 23 1.72E-5
10 SGTC_3209 9113616 4.07 49.5 µM 4.64E-6 23 2.37E-5
11 SGTC_67 0335-0847 4.04 266.0 µM 5.24E-6 ubiquinone biosynthesis & proteasome 117 2.63E-5
12 SGTC_1984 st072354 3.66 53.1 µM 3.36E-5 22 1.27E-4
13 SGTC_43 0570-0105 3.64 72.5 µM 3.57E-5 ERG2 118 1.34E-4
14 SGTC_86 0417-1630 3.63 471.9 µM 3.75E-5 ubiquinone biosynthesis & proteasome 173 1.40E-4
15 SGTC_2316 5844804 3.57 197.4 µM 5.04E-5 49 1.80E-4
16 SGTC_491 tetrandrine 3.50 80.3 µM 6.73E-5 17 2.30E-4
17 SGTC_2619 obliquin 3.46 87.9 µM 8.02E-5 cell wall 179 2.66E-4
18 SGTC_2617 dihydrotanshinone i 3.36 20.8 µM 1.23E-4 copper-dependent oxidative stress 70 3.84E-4
19 SGTC_514 4466-0038 3.34 2.6 nM 1.36E-4 cell wall 198 4.16E-4
20 SGTC_1540 guanosine 3.32 70.6 µM 1.48E-4 21 4.49E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.428 4.45E-149 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.340 1.43E-91 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.321 4.48E-81 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.319 2.96E-80 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.318 7.77E-80 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.310 7.18E-76 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.303 6.68E-72 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.302 7.97E-72 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.299 2.14E-70 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.282 3.01E-62 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.280 1.50E-61 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.275 2.27E-59 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.271 1.75E-57 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.269 1.21E-56 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.262 8.42E-54 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation