HIPHOP chemogenomics database

YGR036C / CAX4

Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR036C / CAX4

Click on Significant Values for Screen Details

Top fitness defect scores for YGR036C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3089	9117425	3.49	49.5 µM	1.07E-4		44	2.45E-4
2	SGTC_1981	st071826	3.20	47.0 µM	3.53E-4		31	6.99E-4
3	SGTC_2821	7996764	3.07	71.4 µM	5.75E-4		93	0.00107
4	SGTC_1902	st060212	2.97	70.5 µM	8.27E-4		65	0.00148
5	SGTC_98	0074-0023	2.96	107.7 µM	8.61E-4	Golgi	86	0.00153
6	SGTC_1557	sumaresinolic acid	2.95	42.3 µM	9.10E-4		62	0.00161
7	SGTC_1324	1418-0026	2.95	34.4 µM	9.14E-4		50	0.00161
8	SGTC_789	1309-1135	2.94	70.6 µM	9.34E-4	ERG2	80	0.00164
9	SGTC_1627	st003713	2.93	25.6 µM	9.71E-4	calcium & mitochondrial duress	162	0.00170
10	SGTC_1622	st003707	2.89	19.4 µM	0.00111	calcium & mitochondrial duress	112	0.00192
11	SGTC_774	k060-0086	2.88	136.0 µM	0.00115		70	0.00197
12	SGTC_2415	st077333	2.88	57.7 µM	0.00116		127	0.00200
13	SGTC_1624	st003710	2.87	6.2 µM	0.00119	calcium & mitochondrial duress	103	0.00204
14	SGTC_1899	st063254	2.86	59.6 µM	0.00125		48	0.00213
15	SGTC_416	estradiol valerate	2.84	100.0 µM	0.00132		57	0.00222
16	SGTC_2572	astragaloside iv	2.82	100.0 µM	0.00144		91	0.00241
17	SGTC_1982	st072467	2.81	71.9 µM	0.00147		108	0.00244
18	SGTC_1350	1495-0454	2.79	146.0 µM	0.00160		93	0.00264
19	SGTC_3185	9108267	2.77	49.5 µM	0.00174	60S ribosome export	89	0.00284
20	SGTC_2844	9010103	2.75	26.0 µM	0.00186		110	0.00301

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.198	6.13E-31	YDR478W	SNM1	het	Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.195	5.68E-30	YJR052W	RAD7	hom	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.144	4.58E-17	YOR218C_d	YOR218C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W
0.134	7.06E-15	YBL041W	PRE7	het	Beta 6 subunit of the 20S proteasome
0.132	1.69E-14	YMR308C	PSE1	het	Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.131	2.77E-14	YDL060W	TSR1	het	Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.123	7.74E-13	YKL196C	YKT6	het	Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.122	1.19E-12	YDR416W	SYF1	het	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.121	1.64E-12	YLR223C	IFH1	het	Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.121	2.07E-12	YKL094W	YJU3	hom	Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.117	9.89E-12	YIL147C	SLN1	het	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.110	1.50E-10	YPL231W	FAS2	het	Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
0.110	1.57E-10	YGL112C	TAF6	het	Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
0.110	2.03E-10	YGL137W	SEC27	het	Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
0.107	4.49E-10	YJL156C	SSY5	het	Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p