YGR036C / CAX4

Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR036C / CAX4

Click on Significant Values for Screen Details ID:SGTC_98|Compound:0074-0023|FD-Score:2.96|P-value:8.61E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:-3.27|P-value:1.54E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-2.81|P-value:9.08E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.05|P-value:3.67E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-4.94|P-value:2.96E-8 ID:SGTC_739|Compound:1486-1183|FD-Score:-3.08|P-value:3.29E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:2.94|P-value:9.34E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.88|P-value:9.62E-6 ID:SGTC_1324|Compound:1418-0026|FD-Score:2.95|P-value:9.14E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.52|P-value:5.18E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:2.95|P-value:9.10E-4 ID:SGTC_1605|Compound:st000082|FD-Score:-3.49|P-value:5.87E-5 ID:SGTC_1606|Compound:st000094|FD-Score:-2.98|P-value:4.87E-4 ID:SGTC_1627|Compound:st003713|FD-Score:2.93|P-value:9.71E-4 ID:SGTC_1811|Compound:st050069|FD-Score:-3.05|P-value:3.68E-4 ID:SGTC_1902|Compound:st060212|FD-Score:2.97|P-value:8.27E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.20|P-value:3.53E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-2.91|P-value:6.40E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.17|P-value:2.32E-6 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.01|P-value:4.38E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.36|P-value:1.06E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-2.95|P-value:5.45E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.07|P-value:5.75E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-2.82|P-value:8.95E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-5.27|P-value:3.75E-9 ID:SGTC_2960|Compound:9079389|FD-Score:-6.32|P-value:2.43E-12 ID:SGTC_2965|Compound:9082772|FD-Score:-5.59|P-value:4.62E-10 ID:SGTC_3075|Compound:9116269|FD-Score:-3.22|P-value:1.85E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.49|P-value:1.07E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-3.59|P-value:3.81E-5 ID:SGTC_3194|Compound:9111903|FD-Score:-2.86|P-value:7.73E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:2.96|P-value:8.61E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:-3.27|P-value:1.54E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-2.81|P-value:9.08E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.05|P-value:3.67E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-4.94|P-value:2.96E-8 ID:SGTC_739|Compound:1486-1183|FD-Score:-3.08|P-value:3.29E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:2.94|P-value:9.34E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.88|P-value:9.62E-6 ID:SGTC_1324|Compound:1418-0026|FD-Score:2.95|P-value:9.14E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.52|P-value:5.18E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:2.95|P-value:9.10E-4 ID:SGTC_1605|Compound:st000082|FD-Score:-3.49|P-value:5.87E-5 ID:SGTC_1606|Compound:st000094|FD-Score:-2.98|P-value:4.87E-4 ID:SGTC_1627|Compound:st003713|FD-Score:2.93|P-value:9.71E-4 ID:SGTC_1811|Compound:st050069|FD-Score:-3.05|P-value:3.68E-4 ID:SGTC_1902|Compound:st060212|FD-Score:2.97|P-value:8.27E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.20|P-value:3.53E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-2.91|P-value:6.40E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.17|P-value:2.32E-6 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.01|P-value:4.38E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.36|P-value:1.06E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-2.95|P-value:5.45E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.07|P-value:5.75E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-2.82|P-value:8.95E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-5.27|P-value:3.75E-9 ID:SGTC_2960|Compound:9079389|FD-Score:-6.32|P-value:2.43E-12 ID:SGTC_2965|Compound:9082772|FD-Score:-5.59|P-value:4.62E-10 ID:SGTC_3075|Compound:9116269|FD-Score:-3.22|P-value:1.85E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.49|P-value:1.07E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-3.59|P-value:3.81E-5 ID:SGTC_3194|Compound:9111903|FD-Score:-2.86|P-value:7.73E-4

Top fitness defect scores for YGR036C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3089 9117425 3.49 49.5 µM 1.07E-4 44 2.45E-4
2 SGTC_1981 st071826 3.20 47.0 µM 3.53E-4 31 6.99E-4
3 SGTC_2821 7996764 3.07 71.4 µM 5.75E-4 93 0.00107
4 SGTC_1902 st060212 2.97 70.5 µM 8.27E-4 65 0.00148
5 SGTC_98 0074-0023 2.96 107.7 µM 8.61E-4 Golgi 86 0.00153
6 SGTC_1557 sumaresinolic acid 2.95 42.3 µM 9.10E-4 62 0.00161
7 SGTC_1324 1418-0026 2.95 34.4 µM 9.14E-4 50 0.00161
8 SGTC_789 1309-1135 2.94 70.6 µM 9.34E-4 ERG2 80 0.00164
9 SGTC_1627 st003713 2.93 25.6 µM 9.71E-4 calcium & mitochondrial duress 162 0.00170
10 SGTC_1622 st003707 2.89 19.4 µM 0.00111 calcium & mitochondrial duress 112 0.00192
11 SGTC_774 k060-0086 2.88 136.0 µM 0.00115 70 0.00197
12 SGTC_2415 st077333 2.88 57.7 µM 0.00116 127 0.00200
13 SGTC_1624 st003710 2.87 6.2 µM 0.00119 calcium & mitochondrial duress 103 0.00204
14 SGTC_1899 st063254 2.86 59.6 µM 0.00125 48 0.00213
15 SGTC_416 estradiol valerate 2.84 100.0 µM 0.00132 57 0.00222
16 SGTC_2572 astragaloside iv 2.82 100.0 µM 0.00144 91 0.00241
17 SGTC_1982 st072467 2.81 71.9 µM 0.00147 108 0.00244
18 SGTC_1350 1495-0454 2.79 146.0 µM 0.00160 93 0.00264
19 SGTC_3185 9108267 2.77 49.5 µM 0.00174 60S ribosome export 89 0.00284
20 SGTC_2844 9010103 2.75 26.0 µM 0.00186 110 0.00301

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 6.13E-31 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.195 5.68E-30 YJR052W RAD7 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.144 4.58E-17 YOR218C_d YOR218C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W
0.134 7.06E-15 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.132 1.69E-14 YMR308C PSE1 het Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.131 2.77E-14 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.123 7.74E-13 YKL196C YKT6 het Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.122 1.19E-12 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.121 1.64E-12 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.121 2.07E-12 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.117 9.89E-12 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.110 1.50E-10 YPL231W FAS2 het Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
0.110 1.57E-10 YGL112C TAF6 het Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
0.110 2.03E-10 YGL137W SEC27 het Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
0.107 4.49E-10 YJL156C SSY5 het Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p