HIPHOP chemogenomics database

YGR037C / ACB1

Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR037C / ACB1

Click on Significant Values for Screen Details

Top fitness defect scores for YGR037C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2416	tofa	28.90	880.0 nM	4.40E-99	sphingolipid biosynthesis & PDR1	2	5.74E-184
2	SGTC_951	1171-0579	23.10	82.7 µM	3.46E-64	cell wall	1	1.17E-118
3	SGTC_2248	tofa	19.40	1.1 µM	1.23E-45	sphingolipid biosynthesis & PDR1	2	5.99E-84
4	SGTC_70	0141-0289	12.60	43.3 µM	2.01E-20	mitochondrial stress	13	8.45E-37
5	SGTC_75	0159-0059	11.50	199.0 µM	2.15E-17	fatty acid desaturase (OLE1)	1	3.87E-31
6	SGTC_662	k832-1615	11.40	104.0 µM	4.42E-17		2	1.48E-30
7	SGTC_767	0929-0023	11.10	86.0 µM	3.22E-16	TRP & mitochondrial translation	3	6.01E-29
8	SGTC_266	formosanin C	10.40	406.0 nM	2.09E-14	sphingolipid biosynthesis & PDR1	13	1.45E-25
9	SGTC_138	0850-0259	9.38	40.9 µM	4.55E-12	cell wall	49	3.31E-21
10	SGTC_3266	9136860	8.93	49.5 µM	4.24E-11	cell wall	10	2.11E-19
11	SGTC_3016	9080866	8.50	49.5 µM	3.25E-10		1	9.38E-18
12	SGTC_3311	9131146	8.38	2.9 µM	5.61E-10	cell wall	27	2.59E-17
13	SGTC_513	4245-1575	8.02	41.7 µM	2.80E-9	unfolded protein response	27	5.15E-16
14	SGTC_1363	1636-0063	7.70	10.4 µM	1.13E-8	Golgi	4	6.91E-15
15	SGTC_1568	digitonin	7.46	820.0 nM	3.05E-8	sphingolipid biosynthesis & PDR1	8	4.35E-14
16	SGTC_527	4476-4215	7.41	268.0 µM	3.75E-8	PDR1	7	6.39E-14
17	SGTC_160	3453-0671	7.28	289.7 µM	6.40E-8		6	1.72E-13
18	SGTC_2315	7733312	7.27	200.0 µM	6.53E-8		3	1.79E-13
19	SGTC_275	trichlorophene	7.18	5.7 µM	9.19E-8	mitochondrial stress	90	3.36E-13
20	SGTC_2576	guaiol	7.14	23.1 µM	1.10E-7		3	4.73E-13

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.345	2.45E-94	YKR028W	SAP190	hom	Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.256	3.49E-51	YJR059W	PTK2	hom	Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
0.251	2.09E-49	YDL066W	IDP1	hom	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.245	2.97E-47	YLR420W	URA4	hom	Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.231	5.07E-42	YIL036W	CST6	hom	Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication
0.216	1.02E-36	YNL229C	URE2	hom	Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.206	1.65E-33	YMR102C_p	YMR102C_p	hom	Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.206	1.71E-33	YBL006C	LDB7	hom	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.205	2.43E-33	YJR111C_p	YJR111C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.202	2.46E-32	YGL013C	PDR1	hom	Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.202	2.72E-32	YCL005W	LDB16	hom	Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.200	1.11E-31	YKL216W	URA1	hom	Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
0.198	4.57E-31	YBR023C	CHS3	hom	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.198	7.13E-31	YKL076C_d	PSY1_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.197	1.33E-30	YMR242C	RPL20A	hom	Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication