HIPHOP chemogenomics database

YGR044C / RME1

Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR044C / RME1

Click on Significant Values for Screen Details

Top fitness defect scores for YGR044C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_46	0329-0187a	4.83	2.2 µM	4.27E-11		42	6.84E-7
2	SGTC_2771	fluoxetine	3.97	41.0 µM	4.89E-8		20	3.66E-5
3	SGTC_2483	5729050	3.54	27.2 µM	9.61E-7		35	1.99E-4
4	SGTC_742	0kpi-0133	3.35	140.0 µM	3.37E-6	ERG2	37	4.07E-4
5	SGTC_2027	5150920	3.31	200.0 µM	4.32E-6		32	4.69E-4
6	SGTC_75	0159-0059	3.29	199.0 µM	4.77E-6	fatty acid desaturase (OLE1)	41	4.96E-4
7	SGTC_64	000l-0018	3.18	272.1 µM	9.68E-6	ubiquinone biosynthesis & proteasome	204	7.43E-4
8	SGTC_165	k038-0023	3.05	64.4 µM	2.08E-5	ubiquinone biosynthesis & proteasome	132	0.00115
9	SGTC_425	3825-7017	3.04	13.1 µM	2.23E-5		74	0.00120
10	SGTC_2420	aureobasidin a	3.00	50.0 nM	2.70E-5		96	0.00134
11	SGTC_424	splitomicin	2.95	100.0 mM	3.66E-5		72	0.00159
12	SGTC_1739	st037196	2.95	92.5 µM	3.66E-5		70	0.00159
13	SGTC_975	1335-0046	2.93	28.5 µM	4.10E-5	RPP1 & pyrimidine depletion	98	0.00170
14	SGTC_36	0335-0881	2.87	14.2 µM	5.60E-5	ubiquinone biosynthesis & proteasome	195	0.00204
15	SGTC_43	0570-0105	2.87	72.5 µM	5.84E-5	ERG2	202	0.00208
16	SGTC_2032	5185112	2.78	26.0 µM	9.32E-5		64	0.00273
17	SGTC_1727	st034309	2.73	9.9 µM	1.18E-4		132	0.00313
18	SGTC_51	1013-0126	2.73	23.4 µM	1.24E-4		80	0.00321
19	SGTC_8	0354-0001	2.72	70.0 µM	1.26E-4		173	0.00326
20	SGTC_1004	4084-0029	2.72	199.0 µM	1.27E-4		83	0.00326

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.159	2.02E-20	YHR025W	THR1	hom	Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.149	3.83E-18	YGR092W	DBF2	hom	Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis
0.141	1.93E-16	YLR127C	APC2	het	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p
0.128	9.60E-14	YBL041W	PRE7	het	Beta 6 subunit of the 20S proteasome
0.124	8.17E-13	YDR029W_d	YDR029W_d	hom	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.123	7.24E-13	YLR199C	PBA1	hom	Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.123	7.32E-13	YPL144W	POC4	hom	Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.123	7.51E-13	YER094C	PUP3	het	Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.121	1.76E-12	YOL083W	ATG34	hom	Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog
0.120	3.33E-12	YNL056W	OCA2	hom	Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.117	9.85E-12	YER051W	JHD1	hom	JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
0.116	1.44E-11	YDR128W	MTC5	hom	Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress
0.116	1.92E-11	YDL183C	YDL183C	hom	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.115	2.09E-11	YGR061C	ADE6	hom	Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.115	2.09E-11	YOR125C	CAT5	hom	Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation