YGR044C / RME1

Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR044C / RME1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:2.72|P-value:1.26E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:2.55|P-value:3.01E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:2.34|P-value:8.35E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:2.87|P-value:5.60E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:2.87|P-value:5.84E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.83|P-value:4.27E-11 ID:SGTC_50|Compound:0929-0078|FD-Score:-2.32|P-value:9.33E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:2.73|P-value:1.24E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.18|P-value:9.68E-6 ID:SGTC_75|Compound:0159-0059|FD-Score:3.29|P-value:4.77E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:3.05|P-value:2.08E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.37|P-value:7.12E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:2.71|P-value:1.36E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:2.95|P-value:3.66E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:3.04|P-value:2.23E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:2.69|P-value:1.46E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:2.47|P-value:4.44E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:2.30|P-value:9.72E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.35|P-value:3.37E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:2.35|P-value:8.02E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:2.93|P-value:4.10E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:2.72|P-value:1.27E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.48|P-value:4.26E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:2.33|P-value:8.45E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:-2.82|P-value:7.94E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:-2.33|P-value:8.79E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.95|P-value:3.87E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.54|P-value:3.30E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:-3.05|P-value:2.11E-5 ID:SGTC_1547|Compound:harmine|FD-Score:2.34|P-value:8.05E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.08|P-value:1.84E-5 ID:SGTC_1727|Compound:st034309|FD-Score:2.73|P-value:1.18E-4 ID:SGTC_1739|Compound:st037196|FD-Score:2.95|P-value:3.66E-5 ID:SGTC_1847|Compound:st056231|FD-Score:-3.55|P-value:9.32E-7 ID:SGTC_1922|Compound:5578187|FD-Score:-2.47|P-value:4.73E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.31|P-value:4.32E-6 ID:SGTC_2032|Compound:5185112|FD-Score:2.78|P-value:9.32E-5 ID:SGTC_2037|Compound:5169046|FD-Score:2.38|P-value:6.87E-4 ID:SGTC_2048|Compound:5246248|FD-Score:2.56|P-value:2.92E-4 ID:SGTC_2049|Compound:5262831|FD-Score:2.47|P-value:4.45E-4 ID:SGTC_2353|Compound:9059630|FD-Score:-2.65|P-value:1.87E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.00|P-value:2.70E-5 ID:SGTC_2483|Compound:5729050|FD-Score:3.54|P-value:9.61E-7 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-2.58|P-value:2.76E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.09|P-value:1.75E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:2.47|P-value:4.43E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.97|P-value:4.89E-8 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.63|P-value:5.60E-7 ID:SGTC_2803|Compound:7707263|FD-Score:2.36|P-value:7.58E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.55|P-value:9.43E-7 ID:SGTC_2858|Compound:9025781|FD-Score:2.30|P-value:9.65E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-2.33|P-value:9.02E-4 ID:SGTC_2935|Compound:9038016|FD-Score:2.52|P-value:3.45E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-2.80|P-value:8.59E-5 ID:SGTC_3352|Compound:9151559|FD-Score:-2.53|P-value:3.46E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:2.72|P-value:1.26E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:2.55|P-value:3.01E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:2.34|P-value:8.35E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:2.87|P-value:5.60E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:2.87|P-value:5.84E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.83|P-value:4.27E-11 ID:SGTC_50|Compound:0929-0078|FD-Score:-2.32|P-value:9.33E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:2.73|P-value:1.24E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.18|P-value:9.68E-6 ID:SGTC_75|Compound:0159-0059|FD-Score:3.29|P-value:4.77E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:3.05|P-value:2.08E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.37|P-value:7.12E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:2.71|P-value:1.36E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:2.95|P-value:3.66E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:3.04|P-value:2.23E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:2.69|P-value:1.46E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:2.47|P-value:4.44E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:2.30|P-value:9.72E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.35|P-value:3.37E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:2.35|P-value:8.02E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:2.93|P-value:4.10E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:2.72|P-value:1.27E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.48|P-value:4.26E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:2.33|P-value:8.45E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:-2.82|P-value:7.94E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:-2.33|P-value:8.79E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.95|P-value:3.87E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.54|P-value:3.30E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:-3.05|P-value:2.11E-5 ID:SGTC_1547|Compound:harmine|FD-Score:2.34|P-value:8.05E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.08|P-value:1.84E-5 ID:SGTC_1727|Compound:st034309|FD-Score:2.73|P-value:1.18E-4 ID:SGTC_1739|Compound:st037196|FD-Score:2.95|P-value:3.66E-5 ID:SGTC_1847|Compound:st056231|FD-Score:-3.55|P-value:9.32E-7 ID:SGTC_1922|Compound:5578187|FD-Score:-2.47|P-value:4.73E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.31|P-value:4.32E-6 ID:SGTC_2032|Compound:5185112|FD-Score:2.78|P-value:9.32E-5 ID:SGTC_2037|Compound:5169046|FD-Score:2.38|P-value:6.87E-4 ID:SGTC_2048|Compound:5246248|FD-Score:2.56|P-value:2.92E-4 ID:SGTC_2049|Compound:5262831|FD-Score:2.47|P-value:4.45E-4 ID:SGTC_2353|Compound:9059630|FD-Score:-2.65|P-value:1.87E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.00|P-value:2.70E-5 ID:SGTC_2483|Compound:5729050|FD-Score:3.54|P-value:9.61E-7 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-2.58|P-value:2.76E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.09|P-value:1.75E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:2.47|P-value:4.43E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.97|P-value:4.89E-8 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.63|P-value:5.60E-7 ID:SGTC_2803|Compound:7707263|FD-Score:2.36|P-value:7.58E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.55|P-value:9.43E-7 ID:SGTC_2858|Compound:9025781|FD-Score:2.30|P-value:9.65E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-2.33|P-value:9.02E-4 ID:SGTC_2935|Compound:9038016|FD-Score:2.52|P-value:3.45E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-2.80|P-value:8.59E-5 ID:SGTC_3352|Compound:9151559|FD-Score:-2.53|P-value:3.46E-4

Top fitness defect scores for YGR044C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_46 0329-0187a 4.83 2.2 µM 4.27E-11 42 6.84E-7
2 SGTC_2771 fluoxetine 3.97 41.0 µM 4.89E-8 20 3.66E-5
3 SGTC_2483 5729050 3.54 27.2 µM 9.61E-7 35 1.99E-4
4 SGTC_742 0kpi-0133 3.35 140.0 µM 3.37E-6 ERG2 37 4.07E-4
5 SGTC_2027 5150920 3.31 200.0 µM 4.32E-6 32 4.69E-4
6 SGTC_75 0159-0059 3.29 199.0 µM 4.77E-6 fatty acid desaturase (OLE1) 41 4.96E-4
7 SGTC_64 000l-0018 3.18 272.1 µM 9.68E-6 ubiquinone biosynthesis & proteasome 204 7.43E-4
8 SGTC_165 k038-0023 3.05 64.4 µM 2.08E-5 ubiquinone biosynthesis & proteasome 132 0.00115
9 SGTC_425 3825-7017 3.04 13.1 µM 2.23E-5 74 0.00120
10 SGTC_2420 aureobasidin a 3.00 50.0 nM 2.70E-5 96 0.00134
11 SGTC_424 splitomicin 2.95 100.0 mM 3.66E-5 72 0.00159
12 SGTC_1739 st037196 2.95 92.5 µM 3.66E-5 70 0.00159
13 SGTC_975 1335-0046 2.93 28.5 µM 4.10E-5 RPP1 & pyrimidine depletion 98 0.00170
14 SGTC_36 0335-0881 2.87 14.2 µM 5.60E-5 ubiquinone biosynthesis & proteasome 195 0.00204
15 SGTC_43 0570-0105 2.87 72.5 µM 5.84E-5 ERG2 202 0.00208
16 SGTC_2032 5185112 2.78 26.0 µM 9.32E-5 64 0.00273
17 SGTC_1727 st034309 2.73 9.9 µM 1.18E-4 132 0.00313
18 SGTC_51 1013-0126 2.73 23.4 µM 1.24E-4 80 0.00321
19 SGTC_8 0354-0001 2.72 70.0 µM 1.26E-4 173 0.00326
20 SGTC_1004 4084-0029 2.72 199.0 µM 1.27E-4 83 0.00326

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 2.02E-20 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.149 3.83E-18 YGR092W DBF2 hom Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis
0.141 1.93E-16 YLR127C APC2 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p
0.128 9.60E-14 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.124 8.17E-13 YDR029W_d YDR029W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.123 7.24E-13 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.123 7.32E-13 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.123 7.51E-13 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.121 1.76E-12 YOL083W ATG34 hom Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog
0.120 3.33E-12 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.117 9.85E-12 YER051W JHD1 hom JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
0.116 1.44E-11 YDR128W MTC5 hom Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress
0.116 1.92E-11 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.115 2.09E-11 YGR061C ADE6 hom Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.115 2.09E-11 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation