YGR045C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR045C / YGR045C

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-4.44|P-value:7.50E-7 ID:SGTC_334|Compound:1502-1024|FD-Score:2.89|P-value:8.87E-4 ID:SGTC_476|Compound:mead acid|FD-Score:3.64|P-value:4.13E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:4.24|P-value:2.20E-6 ID:SGTC_555|Compound:4296-0685|FD-Score:3.57|P-value:5.70E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:2.93|P-value:7.71E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.13|P-value:3.56E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.32|P-value:1.62E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.90|P-value:1.23E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.79|P-value:2.05E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.65|P-value:3.84E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.40|P-value:1.18E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.40|P-value:1.18E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.85|P-value:9.95E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.93|P-value:6.46E-11 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.58|P-value:4.85E-13 ID:SGTC_1715|Compound:st032160|FD-Score:3.65|P-value:3.93E-5 ID:SGTC_1720|Compound:st037298|FD-Score:2.86|P-value:9.83E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.31|P-value:1.74E-4 ID:SGTC_1756|Compound:st041558|FD-Score:2.92|P-value:8.04E-4 ID:SGTC_2281|Compound:7943571|FD-Score:2.99|P-value:6.10E-4 ID:SGTC_2287|Compound:7945887|FD-Score:2.90|P-value:8.48E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-4.62|P-value:2.80E-7 ID:SGTC_2394|Compound:5221648|FD-Score:3.25|P-value:2.17E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.25|P-value:2.18E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.72|P-value:2.91E-5 ID:SGTC_2465|Compound:5809242|FD-Score:3.13|P-value:3.50E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.88|P-value:1.27E-5 ID:SGTC_2477|Compound:5967686|FD-Score:-3.12|P-value:3.60E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.21|P-value:2.58E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.40|P-value:9.48E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.78|P-value:1.07E-7 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.36|P-value:1.33E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.90|P-value:5.30E-8 ID:SGTC_2563|Compound:tomatine|FD-Score:3.10|P-value:4.01E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.68|P-value:3.38E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.76|P-value:2.33E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.61|P-value:4.53E-5 ID:SGTC_2671|Compound:danthron|FD-Score:3.60|P-value:5.02E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-4.19|P-value:2.82E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-3.48|P-value:7.93E-5 ID:SGTC_2909|Compound:7941780|FD-Score:2.90|P-value:8.49E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-2.91|P-value:8.06E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.29|P-value:1.83E-4 ID:SGTC_3131|Compound:9127911|FD-Score:2.87|P-value:9.68E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.45|P-value:9.15E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.16|P-value:3.18E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-4.44|P-value:7.50E-7 ID:SGTC_334|Compound:1502-1024|FD-Score:2.89|P-value:8.87E-4 ID:SGTC_476|Compound:mead acid|FD-Score:3.64|P-value:4.13E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:4.24|P-value:2.20E-6 ID:SGTC_555|Compound:4296-0685|FD-Score:3.57|P-value:5.70E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:2.93|P-value:7.71E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.13|P-value:3.56E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.32|P-value:1.62E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.90|P-value:1.23E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.79|P-value:2.05E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.65|P-value:3.84E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.40|P-value:1.18E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.40|P-value:1.18E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.85|P-value:9.95E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.93|P-value:6.46E-11 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.58|P-value:4.85E-13 ID:SGTC_1715|Compound:st032160|FD-Score:3.65|P-value:3.93E-5 ID:SGTC_1720|Compound:st037298|FD-Score:2.86|P-value:9.83E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.31|P-value:1.74E-4 ID:SGTC_1756|Compound:st041558|FD-Score:2.92|P-value:8.04E-4 ID:SGTC_2281|Compound:7943571|FD-Score:2.99|P-value:6.10E-4 ID:SGTC_2287|Compound:7945887|FD-Score:2.90|P-value:8.48E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-4.62|P-value:2.80E-7 ID:SGTC_2394|Compound:5221648|FD-Score:3.25|P-value:2.17E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.25|P-value:2.18E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.72|P-value:2.91E-5 ID:SGTC_2465|Compound:5809242|FD-Score:3.13|P-value:3.50E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.88|P-value:1.27E-5 ID:SGTC_2477|Compound:5967686|FD-Score:-3.12|P-value:3.60E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.21|P-value:2.58E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.40|P-value:9.48E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.78|P-value:1.07E-7 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.36|P-value:1.33E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.90|P-value:5.30E-8 ID:SGTC_2563|Compound:tomatine|FD-Score:3.10|P-value:4.01E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.68|P-value:3.38E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.76|P-value:2.33E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.61|P-value:4.53E-5 ID:SGTC_2671|Compound:danthron|FD-Score:3.60|P-value:5.02E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-4.19|P-value:2.82E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-3.48|P-value:7.93E-5 ID:SGTC_2909|Compound:7941780|FD-Score:2.90|P-value:8.49E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-2.91|P-value:8.06E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.29|P-value:1.83E-4 ID:SGTC_3131|Compound:9127911|FD-Score:2.87|P-value:9.68E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.45|P-value:9.15E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.16|P-value:3.18E-4

Top fitness defect scores for YGR045C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2528 xanthyletin 4.40 44.8 µM 9.48E-7 18 5.34E-6
2 SGTC_521 r062-0005 4.24 13.8 µM 2.20E-6 11 1.10E-5
3 SGTC_1122 capsaicin 3.90 818.6 nM 1.23E-5 30 4.81E-5
4 SGTC_1152 3909-8331 3.79 15.9 µM 2.05E-5 11 7.50E-5
5 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 3.76 100.0 µM 2.33E-5 60S ribosome export 24 8.37E-5
6 SGTC_2458 5808907 3.72 16.4 µM 2.91E-5 8 1.01E-4
7 SGTC_2581 avocatin a 3.68 64.0 µM 3.38E-5 sphingolipid biosynthesis & PDR1 64 1.15E-4
8 SGTC_1262 0737-0114 3.65 49.6 µM 3.84E-5 25 1.29E-4
9 SGTC_1715 st032160 3.65 10.2 µM 3.93E-5 51 1.31E-4
10 SGTC_476 mead acid 3.64 10.0 µM 4.13E-5 6 1.37E-4
11 SGTC_2671 danthron 3.60 100.0 µM 5.02E-5 DNA damage response 56 1.62E-4
12 SGTC_555 4296-0685 3.57 37.0 µM 5.70E-5 ergosterol biosynthesis 17 1.81E-4
13 SGTC_1452 4194-0072 3.40 190.0 µM 1.18E-4 28 3.38E-4
14 SGTC_1325 1431-0015 3.40 227.0 µM 1.18E-4 Golgi 36 3.39E-4
15 SGTC_958 1222-0007 3.32 33.0 µM 1.62E-4 52 4.44E-4
16 SGTC_1753 st043925 3.31 64.0 µM 1.74E-4 22 4.73E-4
17 SGTC_2394 5221648 3.25 200.0 µM 2.17E-4 51 5.71E-4
18 SGTC_2419 paclitaxel 3.25 166.5 µM 2.18E-4 84 5.75E-4
19 SGTC_2478 5763493 3.21 32.3 µM 2.58E-4 45 6.64E-4
20 SGTC_3344 9148862 3.16 3.9 µM 3.18E-4 39 7.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.257 1.20E-51 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.256 3.46E-51 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.252 1.17E-49 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.250 7.12E-49 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.243 3.93E-46 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.240 5.48E-45 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.235 2.87E-43 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.228 7.31E-41 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.227 1.97E-40 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.217 6.48E-37 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.215 1.44E-36 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.213 9.58E-36 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.208 4.01E-34 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.202 2.42E-32 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.199 2.18E-31 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress