YGR052W_p / FMP48

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR052W / FMP48

Click on Significant Values for Screen Details ID:SGTC_93|Compound:0109-0045|FD-Score:3.77|P-value:2.77E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.53|P-value:3.69E-4 ID:SGTC_269|Compound:exalamide|FD-Score:-3.26|P-value:8.87E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.50|P-value:6.92E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:3.63|P-value:4.52E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:-3.25|P-value:9.40E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.93|P-value:2.79E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:5.12|P-value:1.19E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.00|P-value:1.24E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:5.40|P-value:3.20E-7 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.71|P-value:3.42E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.91|P-value:1.68E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.41|P-value:2.50E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.39|P-value:9.60E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.48|P-value:7.38E-4 ID:SGTC_1866|Compound:st057638|FD-Score:4.36|P-value:3.08E-5 ID:SGTC_1912|Compound:st060209|FD-Score:5.26|P-value:6.21E-7 ID:SGTC_2012|Compound:4023501|FD-Score:-4.36|P-value:1.63E-5 ID:SGTC_2065|Compound:5221596|FD-Score:4.17|P-value:6.55E-5 ID:SGTC_2099|Compound:5377090|FD-Score:3.61|P-value:4.82E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.88|P-value:1.87E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.10|P-value:8.40E-5 ID:SGTC_2365|Compound:9042475|FD-Score:4.02|P-value:1.13E-4 ID:SGTC_2375|Compound:9072683|FD-Score:-3.36|P-value:6.55E-4 ID:SGTC_2403|Compound:6032726|FD-Score:6.96|P-value:6.26E-11 ID:SGTC_2415|Compound:st077333|FD-Score:4.61|P-value:1.10E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:5.75|P-value:5.64E-8 ID:SGTC_2428|Compound:5615643|FD-Score:3.95|P-value:1.47E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.34|P-value:3.37E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.02|P-value:1.14E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.58|P-value:3.12E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-6.05|P-value:5.01E-9 ID:SGTC_2802|Compound:7925815|FD-Score:-3.93|P-value:9.09E-5 ID:SGTC_2803|Compound:7707263|FD-Score:5.17|P-value:9.64E-7 ID:SGTC_2915|Compound:7971052|FD-Score:4.12|P-value:7.82E-5 ID:SGTC_2959|Compound:9079155|FD-Score:3.85|P-value:2.11E-4 ID:SGTC_2982|Compound:9019404|FD-Score:4.68|P-value:8.33E-6 ID:SGTC_2985|Compound:9022375|FD-Score:5.05|P-value:1.62E-6 ID:SGTC_3011|Compound:9081274|FD-Score:4.41|P-value:2.51E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-3.40|P-value:5.76E-4 ID:SGTC_3315|Compound:9136395|FD-Score:-4.54|P-value:8.02E-6 ID:SGTC_3316|Compound:9136639|FD-Score:4.59|P-value:1.22E-5 ID:SGTC_3326|Compound:9140064|FD-Score:6.16|P-value:6.22E-9 ID:SGTC_93|Compound:0109-0045|FD-Score:3.77|P-value:2.77E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.53|P-value:3.69E-4 ID:SGTC_269|Compound:exalamide|FD-Score:-3.26|P-value:8.87E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.50|P-value:6.92E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:3.63|P-value:4.52E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:-3.25|P-value:9.40E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.93|P-value:2.79E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:5.12|P-value:1.19E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.00|P-value:1.24E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:5.40|P-value:3.20E-7 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.71|P-value:3.42E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.91|P-value:1.68E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.41|P-value:2.50E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.39|P-value:9.60E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.48|P-value:7.38E-4 ID:SGTC_1866|Compound:st057638|FD-Score:4.36|P-value:3.08E-5 ID:SGTC_1912|Compound:st060209|FD-Score:5.26|P-value:6.21E-7 ID:SGTC_2012|Compound:4023501|FD-Score:-4.36|P-value:1.63E-5 ID:SGTC_2065|Compound:5221596|FD-Score:4.17|P-value:6.55E-5 ID:SGTC_2099|Compound:5377090|FD-Score:3.61|P-value:4.82E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.88|P-value:1.87E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.10|P-value:8.40E-5 ID:SGTC_2365|Compound:9042475|FD-Score:4.02|P-value:1.13E-4 ID:SGTC_2375|Compound:9072683|FD-Score:-3.36|P-value:6.55E-4 ID:SGTC_2403|Compound:6032726|FD-Score:6.96|P-value:6.26E-11 ID:SGTC_2415|Compound:st077333|FD-Score:4.61|P-value:1.10E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:5.75|P-value:5.64E-8 ID:SGTC_2428|Compound:5615643|FD-Score:3.95|P-value:1.47E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.34|P-value:3.37E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.02|P-value:1.14E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.58|P-value:3.12E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-6.05|P-value:5.01E-9 ID:SGTC_2802|Compound:7925815|FD-Score:-3.93|P-value:9.09E-5 ID:SGTC_2803|Compound:7707263|FD-Score:5.17|P-value:9.64E-7 ID:SGTC_2915|Compound:7971052|FD-Score:4.12|P-value:7.82E-5 ID:SGTC_2959|Compound:9079155|FD-Score:3.85|P-value:2.11E-4 ID:SGTC_2982|Compound:9019404|FD-Score:4.68|P-value:8.33E-6 ID:SGTC_2985|Compound:9022375|FD-Score:5.05|P-value:1.62E-6 ID:SGTC_3011|Compound:9081274|FD-Score:4.41|P-value:2.51E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-3.40|P-value:5.76E-4 ID:SGTC_3315|Compound:9136395|FD-Score:-4.54|P-value:8.02E-6 ID:SGTC_3316|Compound:9136639|FD-Score:4.59|P-value:1.22E-5 ID:SGTC_3326|Compound:9140064|FD-Score:6.16|P-value:6.22E-9

Top fitness defect scores for YGR052W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2403 6032726 6.96 181.2 µM 6.26E-11 8 1.76E-12
2 SGTC_3326 9140064 6.16 16.4 µM 6.22E-9 7 3.52E-10
3 SGTC_2420 aureobasidin a 5.75 50.0 nM 5.64E-8 12 4.48E-9
4 SGTC_1035 k081-0041 5.40 55.2 µM 3.20E-7 Golgi 8 3.33E-8
5 SGTC_1912 st060209 5.26 90.8 µM 6.21E-7 14 7.14E-8
6 SGTC_2803 7707263 5.17 71.4 µM 9.64E-7 14 1.19E-7
7 SGTC_1029 k015-0030 5.12 64.7 µM 1.19E-6 12 1.52E-7
8 SGTC_2985 9022375 5.05 71.4 µM 1.62E-6 RPP1 & pyrimidine depletion 12 2.15E-7
9 SGTC_1028 k015-0029 4.93 4.8 µM 2.79E-6 7 4.04E-7
10 SGTC_2982 9019404 4.68 26.0 µM 8.33E-6 13 1.43E-6
11 SGTC_2415 st077333 4.61 57.7 µM 1.10E-5 27 1.98E-6
12 SGTC_3316 9136639 4.59 10.6 µM 1.22E-5 8 2.22E-6
13 SGTC_1164 k060-0068 4.41 93.7 µM 2.50E-5 14 5.09E-6
14 SGTC_3011 9081274 4.41 71.4 µM 2.51E-5 6 5.11E-6
15 SGTC_1866 st057638 4.36 64.0 µM 3.08E-5 10 6.46E-6
16 SGTC_2504 purpurogallin 4.34 52.3 µM 3.37E-5 RPP1 & pyrimidine depletion 14 7.19E-6
17 SGTC_2065 5221596 4.17 34.3 µM 6.55E-5 11 1.55E-5
18 SGTC_2915 7971052 4.12 15.2 µM 7.82E-5 5 1.90E-5
19 SGTC_2361 9034121 4.10 116.0 µM 8.40E-5 RSC complex & mRNA processing 16 2.06E-5
20 SGTC_2365 9042475 4.02 200.0 µM 1.13E-4 35 2.90E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 7.47E-10 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.093 6.35E-8 YKR044W UIP5 hom Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates
0.092 1.06E-7 YDR246W TRS23 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
0.087 4.18E-7 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.079 4.18E-6 YPL229W_p YPL229W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication
0.078 5.84E-6 YBR232C_d YBR232C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.076 1.03E-5 YLR416C_d YLR416C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.076 1.08E-5 YBR079C RPG1 het eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation
0.073 2.34E-5 YKR012C_d YKR012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
0.072 2.73E-5 YGR189C CRH1 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress
0.072 3.28E-5 YLR130C ZRT2 hom Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor
0.071 3.56E-5 YJL075C_d APQ13_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate
0.070 4.44E-5 YLR272C YCS4 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.070 4.56E-5 YLR011W LOT6 hom FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions
0.069 7.09E-5 YDR325W YCG1 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation