YGR055W / MUP1

High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR055W / MUP1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:5.74|P-value:7.97E-9 ID:SGTC_8|Compound:0354-0001|FD-Score:20.00|P-value:1.34E-86 ID:SGTC_13|Compound:0199-0087|FD-Score:7.64|P-value:2.71E-14 ID:SGTC_14|Compound:0354-0009|FD-Score:8.01|P-value:1.49E-15 ID:SGTC_17|Compound:0960-0276|FD-Score:5.67|P-value:1.13E-8 ID:SGTC_18|Compound:0111-0177|FD-Score:8.29|P-value:1.61E-16 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.64|P-value:3.01E-11 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.40|P-value:4.17E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.98|P-value:4.41E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.16|P-value:9.43E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.68|P-value:2.04E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:3.42|P-value:3.72E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.32|P-value:5.29E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:4.02|P-value:3.78E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:3.40|P-value:4.03E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.28|P-value:6.07E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.51|P-value:2.79E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:-3.21|P-value:7.90E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.27|P-value:6.33E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.40|P-value:4.04E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.31|P-value:5.53E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.33|P-value:5.20E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.38|P-value:4.32E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.81|P-value:8.64E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.57|P-value:2.24E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.18|P-value:8.65E-4 ID:SGTC_1626|Compound:st003712|FD-Score:4.25|P-value:1.42E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.27|P-value:6.57E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.32|P-value:5.54E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.44|P-value:3.56E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.41|P-value:3.83E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-3.66|P-value:1.59E-4 ID:SGTC_2124|Compound:5246320|FD-Score:4.84|P-value:9.12E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.18|P-value:8.69E-4 ID:SGTC_2155|Compound:5570423|FD-Score:-3.48|P-value:3.13E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.65|P-value:1.60E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-3.71|P-value:1.32E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.96|P-value:4.78E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-3.60|P-value:2.02E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.53|P-value:2.62E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.81|P-value:8.55E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.81|P-value:1.10E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.26|P-value:3.45E-10 ID:SGTC_2671|Compound:danthron|FD-Score:3.67|P-value:1.51E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.83|P-value:1.69E-18 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.39|P-value:4.16E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.58|P-value:2.16E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.35|P-value:4.85E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.98|P-value:4.46E-5 ID:SGTC_2859|Compound:9028643|FD-Score:3.19|P-value:8.32E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.34|P-value:5.07E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.22|P-value:7.58E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.30|P-value:5.76E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.21|P-value:7.91E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.30|P-value:5.89E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.24|P-value:7.11E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.39|P-value:4.15E-4 ID:SGTC_3247|Compound:9135149|FD-Score:4.01|P-value:3.94E-5 ID:SGTC_3316|Compound:9136639|FD-Score:-4.12|P-value:2.47E-5 ID:SGTC_3319|Compound:9138450|FD-Score:4.38|P-value:8.13E-6 ID:SGTC_3323|Compound:9138564|FD-Score:-3.25|P-value:6.84E-4 ID:SGTC_3334|Compound:9142812|FD-Score:5.93|P-value:2.64E-9 ID:SGTC_7|Compound:0192-1582|FD-Score:5.74|P-value:7.97E-9 ID:SGTC_8|Compound:0354-0001|FD-Score:20.00|P-value:1.34E-86 ID:SGTC_13|Compound:0199-0087|FD-Score:7.64|P-value:2.71E-14 ID:SGTC_14|Compound:0354-0009|FD-Score:8.01|P-value:1.49E-15 ID:SGTC_17|Compound:0960-0276|FD-Score:5.67|P-value:1.13E-8 ID:SGTC_18|Compound:0111-0177|FD-Score:8.29|P-value:1.61E-16 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.64|P-value:3.01E-11 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.40|P-value:4.17E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.98|P-value:4.41E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.16|P-value:9.43E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.68|P-value:2.04E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:3.42|P-value:3.72E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.32|P-value:5.29E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:4.02|P-value:3.78E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:3.40|P-value:4.03E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.28|P-value:6.07E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.51|P-value:2.79E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:-3.21|P-value:7.90E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.27|P-value:6.33E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.40|P-value:4.04E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.31|P-value:5.53E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.33|P-value:5.20E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.38|P-value:4.32E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.81|P-value:8.64E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.57|P-value:2.24E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.18|P-value:8.65E-4 ID:SGTC_1626|Compound:st003712|FD-Score:4.25|P-value:1.42E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.27|P-value:6.57E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.32|P-value:5.54E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.44|P-value:3.56E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.41|P-value:3.83E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-3.66|P-value:1.59E-4 ID:SGTC_2124|Compound:5246320|FD-Score:4.84|P-value:9.12E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.18|P-value:8.69E-4 ID:SGTC_2155|Compound:5570423|FD-Score:-3.48|P-value:3.13E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.65|P-value:1.60E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-3.71|P-value:1.32E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.96|P-value:4.78E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-3.60|P-value:2.02E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.53|P-value:2.62E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.81|P-value:8.55E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.81|P-value:1.10E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.26|P-value:3.45E-10 ID:SGTC_2671|Compound:danthron|FD-Score:3.67|P-value:1.51E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.83|P-value:1.69E-18 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.39|P-value:4.16E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.58|P-value:2.16E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.35|P-value:4.85E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.98|P-value:4.46E-5 ID:SGTC_2859|Compound:9028643|FD-Score:3.19|P-value:8.32E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.34|P-value:5.07E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.22|P-value:7.58E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.30|P-value:5.76E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.21|P-value:7.91E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.30|P-value:5.89E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.24|P-value:7.11E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.39|P-value:4.15E-4 ID:SGTC_3247|Compound:9135149|FD-Score:4.01|P-value:3.94E-5 ID:SGTC_3316|Compound:9136639|FD-Score:-4.12|P-value:2.47E-5 ID:SGTC_3319|Compound:9138450|FD-Score:4.38|P-value:8.13E-6 ID:SGTC_3323|Compound:9138564|FD-Score:-3.25|P-value:6.84E-4 ID:SGTC_3334|Compound:9142812|FD-Score:5.93|P-value:2.64E-9

Top fitness defect scores for YGR055W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_8 0354-0001 20.00 70.0 µM 1.34E-86 1 3.16E-89
2 SGTC_2688 kanamycin b 8.83 96.7 µM 1.69E-18 calcium & mitochondrial duress 46 5.21E-19
3 SGTC_18 0111-0177 8.29 500.0 nM 1.61E-16 8 5.69E-17
4 SGTC_14 0354-0009 8.01 295.0 µM 1.49E-15 2 5.64E-16
5 SGTC_13 0199-0087 7.64 65.0 µM 2.71E-14 ERG2 2 1.12E-14
6 SGTC_46 0329-0187a 6.64 2.2 µM 3.01E-11 22 1.54E-11
7 SGTC_2651 1327-0036 6.26 5.0 µM 3.45E-10 66 1.91E-10
8 SGTC_3334 9142812 5.93 21.9 µM 2.64E-9 5 1.55E-9
9 SGTC_7 0192-1582 5.74 4.2 µM 7.97E-9 27 4.83E-9
10 SGTC_17 0960-0276 5.67 49.8 µM 1.13E-8 6 6.94E-9
11 SGTC_2124 5246320 4.84 200.0 µM 9.12E-7 heme biosynthesis & mitochondrial translocase 11 6.37E-7
12 SGTC_245 methotrexate 4.68 289.6 µM 2.04E-6 27 1.46E-6
13 SGTC_3319 9138450 4.38 16.8 µM 8.13E-6 11 6.06E-6
14 SGTC_1626 st003712 4.25 1.8 µM 1.42E-5 17 1.08E-5
15 SGTC_526 4469-0568 4.02 170.0 µM 3.78E-5 azole & statin 35 2.95E-5
16 SGTC_3247 9135149 4.01 49.5 µM 3.94E-5 DNA damage response 22 3.07E-5
17 SGTC_64 000l-0018 3.98 272.1 µM 4.41E-5 ubiquinone biosynthesis & proteasome 150 3.46E-5
18 SGTC_2827 7993847 3.98 71.4 µM 4.46E-5 24 3.50E-5
19 SGTC_2340 7987427 3.96 183.4 µM 4.78E-5 34 3.76E-5
20 SGTC_2460 5552655 3.81 174.2 µM 8.55E-5 amide catabolism 34 6.83E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.266 2.38E-55 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.257 9.79E-52 YHL029C_p OCA5_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.232 5.14E-42 YMR070W MOT3 hom Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion
0.229 4.47E-41 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.227 3.02E-40 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.207 9.41E-34 YCR095C_p OCA4_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.204 9.77E-33 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation
0.204 1.23E-32 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.200 1.90E-31 YNL032W SIW14 hom Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
0.194 1.41E-29 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.186 1.72E-27 YLR180W SAM1 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication
0.183 1.12E-26 YDR067C_p OCA6_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT
0.172 1.30E-23 YDL175C AIR2 hom RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication
0.172 1.50E-23 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.171 2.01E-23 YOL075C_p YOL075C_p hom Putative ABC transporter