YGR077C / PEX8

Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR077C / PEX8

Click on Significant Values for Screen Details ID:SGTC_179|Compound:1273-0063|FD-Score:-2.38|P-value:6.09E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-2.72|P-value:1.05E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:2.33|P-value:6.38E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:2.47|P-value:3.32E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.12|P-value:8.54E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.00|P-value:2.25E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.29|P-value:7.65E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.18|P-value:5.95E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:2.63|P-value:1.38E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:2.64|P-value:1.35E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.69|P-value:2.64E-15 ID:SGTC_837|Compound:0091-0265|FD-Score:3.09|P-value:1.03E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:-2.91|P-value:3.65E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-2.47|P-value:3.96E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:2.69|P-value:1.02E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.46|P-value:1.17E-6 ID:SGTC_1221|Compound:2958-7315|FD-Score:-2.50|P-value:3.32E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:2.66|P-value:1.19E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.75|P-value:9.04E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.37|P-value:5.41E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.05|P-value:1.60E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-2.36|P-value:6.75E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-2.42|P-value:4.92E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.62|P-value:7.99E-15 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.08|P-value:1.28E-8 ID:SGTC_1726|Compound:st035556|FD-Score:2.86|P-value:4.07E-5 ID:SGTC_1800|Compound:st050079|FD-Score:2.90|P-value:3.18E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.06|P-value:1.20E-5 ID:SGTC_1818|Compound:st052136|FD-Score:2.28|P-value:8.00E-4 ID:SGTC_1851|Compound:st056236|FD-Score:2.38|P-value:4.97E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-2.32|P-value:7.98E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.67|P-value:1.14E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-2.29|P-value:9.35E-4 ID:SGTC_2092|Compound:5303694|FD-Score:-2.46|P-value:4.08E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.88|P-value:3.55E-5 ID:SGTC_2243|Compound:6634756|FD-Score:2.36|P-value:5.54E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-2.63|P-value:1.69E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-2.99|P-value:2.36E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.56|P-value:2.46E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-2.48|P-value:3.68E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-2.58|P-value:2.23E-4 ID:SGTC_2709|Compound:st078560|FD-Score:2.58|P-value:1.85E-4 ID:SGTC_2821|Compound:7996764|FD-Score:2.33|P-value:6.58E-4 ID:SGTC_2823|Compound:7987624|FD-Score:2.68|P-value:1.10E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.83|P-value:6.59E-8 ID:SGTC_2916|Compound:7875993|FD-Score:2.26|P-value:8.88E-4 ID:SGTC_2930|Compound:9013230|FD-Score:2.77|P-value:6.73E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-3.40|P-value:1.79E-6 ID:SGTC_2953|Compound:9074162|FD-Score:2.56|P-value:2.04E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-2.29|P-value:9.33E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-2.38|P-value:6.09E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-2.72|P-value:1.05E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:2.33|P-value:6.38E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:2.47|P-value:3.32E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.12|P-value:8.54E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.00|P-value:2.25E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.29|P-value:7.65E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.18|P-value:5.95E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:2.63|P-value:1.38E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:2.64|P-value:1.35E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.69|P-value:2.64E-15 ID:SGTC_837|Compound:0091-0265|FD-Score:3.09|P-value:1.03E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:-2.91|P-value:3.65E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-2.47|P-value:3.96E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:2.69|P-value:1.02E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.46|P-value:1.17E-6 ID:SGTC_1221|Compound:2958-7315|FD-Score:-2.50|P-value:3.32E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:2.66|P-value:1.19E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.75|P-value:9.04E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.37|P-value:5.41E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.05|P-value:1.60E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-2.36|P-value:6.75E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-2.42|P-value:4.92E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.62|P-value:7.99E-15 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.08|P-value:1.28E-8 ID:SGTC_1726|Compound:st035556|FD-Score:2.86|P-value:4.07E-5 ID:SGTC_1800|Compound:st050079|FD-Score:2.90|P-value:3.18E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.06|P-value:1.20E-5 ID:SGTC_1818|Compound:st052136|FD-Score:2.28|P-value:8.00E-4 ID:SGTC_1851|Compound:st056236|FD-Score:2.38|P-value:4.97E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-2.32|P-value:7.98E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.67|P-value:1.14E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-2.29|P-value:9.35E-4 ID:SGTC_2092|Compound:5303694|FD-Score:-2.46|P-value:4.08E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.88|P-value:3.55E-5 ID:SGTC_2243|Compound:6634756|FD-Score:2.36|P-value:5.54E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-2.63|P-value:1.69E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-2.99|P-value:2.36E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.56|P-value:2.46E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-2.48|P-value:3.68E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-2.58|P-value:2.23E-4 ID:SGTC_2709|Compound:st078560|FD-Score:2.58|P-value:1.85E-4 ID:SGTC_2821|Compound:7996764|FD-Score:2.33|P-value:6.58E-4 ID:SGTC_2823|Compound:7987624|FD-Score:2.68|P-value:1.10E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.83|P-value:6.59E-8 ID:SGTC_2916|Compound:7875993|FD-Score:2.26|P-value:8.88E-4 ID:SGTC_2930|Compound:9013230|FD-Score:2.77|P-value:6.73E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-3.40|P-value:1.79E-6 ID:SGTC_2953|Compound:9074162|FD-Score:2.56|P-value:2.04E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-2.29|P-value:9.33E-4

Top fitness defect scores for YGR077C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_690 glyoxal 5.69 20.3 µM 2.64E-15 47 6.46E-9
2 SGTC_2874 9043904 3.83 71.4 µM 6.59E-8 15 6.38E-5
3 SGTC_515 4092-1064 3.18 102.0 µM 5.95E-6 plasma membrane duress 91 7.45E-4
4 SGTC_356 1634-0012 3.12 32.5 µM 8.54E-6 57 9.08E-4
5 SGTC_837 0091-0265 3.09 12.5 µM 1.03E-5 ubiquinone biosynthesis & proteasome 54 0.00101
6 SGTC_1803 st050068 3.06 52.4 µM 1.20E-5 NEO1-PIK1 260 0.00110
7 SGTC_1800 st050079 2.90 29.1 µM 3.18E-5 NEO1-PIK1 238 0.00187
8 SGTC_2103 5378138 2.88 10.0 µM 3.55E-5 68 0.00199
9 SGTC_1726 st035556 2.86 14.6 µM 4.07E-5 110 0.00214
10 SGTC_2930 9013230 2.77 14.9 µM 6.73E-5 heme biosynthesis & mitochondrial translocase 122 0.00283
11 SGTC_1163 k060-0048 2.69 49.9 µM 1.02E-4 102 0.00357
12 SGTC_2823 7987624 2.68 58.4 µM 1.10E-4 130 0.00371
13 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 2.67 70.1 µM 1.14E-4 127 0.00379
14 SGTC_1243 0416-0003 2.66 5.7 µM 1.19E-4 PDR1 119 0.00388
15 SGTC_533 1222-0222 2.64 6.7 µM 1.35E-4 PDR1 100 0.00416
16 SGTC_528 3492-0019 2.63 172.0 µM 1.38E-4 calcium & mitochondrial duress 352 0.00422
17 SGTC_2709 st078560 2.58 56.0 µM 1.85E-4 72 0.00494
18 SGTC_2953 9074162 2.56 66.5 µM 2.04E-4 96 0.00522
19 SGTC_352 k048-0007 2.47 5.1 µM 3.32E-4 ERAD & cell cycle 187 0.00684
20 SGTC_1851 st056236 2.38 18.9 µM 4.97E-4 126 0.00858

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.402 1.33E-130 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.399 2.58E-128 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.387 2.27E-120 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.381 1.15E-115 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.378 3.09E-114 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.367 3.61E-107 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.362 3.91E-104 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.335 1.35E-88 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.316 1.65E-78 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.310 1.83E-75 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.306 1.23E-73 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.295 3.07E-68 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.295 7.03E-68 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.285 6.99E-64 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.281 7.91E-62 YNL339C YRF1-6 hom Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p