HIPHOP chemogenomics database

YGR081C / SLX9

Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR081C / SLX9

Click on Significant Values for Screen Details

Top fitness defect scores for YGR081C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3126	9127922	8.39	49.5 µM	2.71E-14	fatty acid desaturase (OLE1)	9	2.47E-17
2	SGTC_2996	9066192	7.66	71.4 µM	3.26E-12		4	9.61E-15
3	SGTC_2688	kanamycin b	7.38	96.7 µM	1.75E-11	calcium & mitochondrial duress	92	7.73E-14
4	SGTC_2232	chlorophetanol	6.61	41.5 µM	1.51E-9	TRP & mitochondrial translation	32	1.96E-11
5	SGTC_2917	7979103	5.44	53.8 µM	5.15E-7		7	2.72E-8
6	SGTC_1722	st034304	4.96	3.6 µM	4.15E-6	mitochondrial processes	11	3.59E-7
7	SGTC_1781	st038725	4.81	66.3 µM	7.50E-6	NEO1	78	7.45E-7
8	SGTC_364	0083-0097	4.64	67.7 µM	1.51E-5		15	1.77E-6
9	SGTC_2687	chenodiol	4.45	100.0 µM	3.04E-5		15	4.20E-6
10	SGTC_1744	st037937	4.41	38.9 µM	3.57E-5		18	5.10E-6
11	SGTC_1352	1496-0991	4.40	99.0 µM	3.75E-5	tubulin folding & SWR complex	25	5.42E-6
12	SGTC_1062	mesoridazine	4.37	14.2 µM	4.11E-5		13	6.08E-6
13	SGTC_2062	5245942	4.31	200.0 µM	5.32E-5		8	8.34E-6
14	SGTC_3087	9117406	4.24	49.5 µM	6.65E-5		14	1.10E-5
15	SGTC_1719	st032227	4.18	49.2 µM	8.25E-5		19	1.43E-5
16	SGTC_3041	9091929	4.09	49.5 µM	1.14E-4	redox potentiating	19	2.13E-5
17	SGTC_1068	loratadine	4.05	26.9 µM	1.32E-4		19	2.56E-5
18	SGTC_2307	7538926	4.05	6.3 µM	1.33E-4		41	2.59E-5
19	SGTC_3123	9126162	4.00	49.5 µM	1.58E-4		17	3.18E-5
20	SGTC_1442	4112-3290	3.95	3.0 µM	1.86E-4		12	3.88E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.141	2.45E-16	YCR075W-A_p	YCR075W-A_p	hom	Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.137	1.64E-15	YDR101C	ARX1	hom	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.131	2.19E-14	YHR203C	RPS4B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
0.125	3.20E-13	YGR214W	RPS0A	hom	Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.125	3.35E-13	YJL136C	RPS21B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.119	3.85E-12	YDL081C	RPP1A	hom	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.113	5.69E-11	YLR048W	RPS0B	hom	Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.109	2.25E-10	YOR293W	RPS10A	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.106	7.29E-10	YJL053W	PEP8	hom	Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.105	1.23E-9	YDL033C	SLM3	hom	tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
0.103	2.46E-9	YGL088W_d	YGL088W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
0.101	4.97E-9	YML036W	CGI121	hom	Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification
0.099	1.08E-8	YFR051C	RET2	het	Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.098	1.14E-8	YPL125W	KAP120	hom	Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.098	1.28E-8	YGL246C	RAI1	hom	Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z