YGR084C / MRP13

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR084C / MRP13

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:-2.90|P-value:7.61E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.16|P-value:9.04E-9 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.50|P-value:6.46E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.86|P-value:1.25E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:3.28|P-value:1.74E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.62|P-value:4.00E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.68|P-value:2.92E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:-2.83|P-value:9.90E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.22|P-value:2.18E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.57|P-value:4.88E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.58|P-value:4.52E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:3.10|P-value:3.62E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.37|P-value:1.21E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.39|P-value:1.07E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.68|P-value:2.99E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.02|P-value:4.93E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.77|P-value:9.64E-8 ID:SGTC_751|Compound:0833-0568|FD-Score:3.04|P-value:4.54E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-4.10|P-value:3.85E-6 ID:SGTC_771|Compound:0250-0039|FD-Score:-2.86|P-value:9.03E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:2.84|P-value:9.93E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:-3.00|P-value:5.27E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.84|P-value:1.38E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.35|P-value:1.31E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.38|P-value:1.15E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-2.91|P-value:7.50E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:-3.81|P-value:1.58E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.63|P-value:3.65E-5 ID:SGTC_1519|Compound:esterone|FD-Score:-3.15|P-value:2.93E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.14|P-value:3.11E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:7.30|P-value:8.08E-16 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.11|P-value:3.41E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.04|P-value:4.53E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.20|P-value:2.42E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.71|P-value:2.58E-5 ID:SGTC_1652|Compound:st011932|FD-Score:2.92|P-value:7.29E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.57|P-value:3.05E-7 ID:SGTC_1769|Compound:st044406|FD-Score:2.94|P-value:6.78E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.04|P-value:4.49E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-3.88|P-value:1.11E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-3.23|P-value:2.09E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.25|P-value:1.92E-4 ID:SGTC_1979|Compound:st071809|FD-Score:4.20|P-value:2.32E-6 ID:SGTC_1990|Compound:st072050|FD-Score:-3.63|P-value:3.65E-5 ID:SGTC_2000|Compound:st075254|FD-Score:4.91|P-value:4.19E-8 ID:SGTC_2173|Compound:5763948|FD-Score:-2.89|P-value:8.02E-4 ID:SGTC_2292|Compound:7671323|FD-Score:4.31|P-value:1.31E-6 ID:SGTC_2295|Compound:7971645|FD-Score:3.50|P-value:6.60E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.12|P-value:3.32E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.19|P-value:2.49E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.26|P-value:1.89E-4 ID:SGTC_2717|Compound:st081029|FD-Score:2.93|P-value:7.09E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-4.04|P-value:5.11E-6 ID:SGTC_3004|Compound:9076122|FD-Score:3.54|P-value:5.62E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-4.64|P-value:2.05E-7 ID:SGTC_3192|Compound:9110362|FD-Score:-4.30|P-value:1.29E-6 ID:SGTC_3196|Compound:9111891|FD-Score:-4.78|P-value:8.74E-8 ID:SGTC_3198|Compound:9112019|FD-Score:-5.08|P-value:1.46E-8 ID:SGTC_17|Compound:0960-0276|FD-Score:-2.90|P-value:7.61E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.16|P-value:9.04E-9 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.50|P-value:6.46E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.86|P-value:1.25E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:3.28|P-value:1.74E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.62|P-value:4.00E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.68|P-value:2.92E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:-2.83|P-value:9.90E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.22|P-value:2.18E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.57|P-value:4.88E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.58|P-value:4.52E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:3.10|P-value:3.62E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.37|P-value:1.21E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.39|P-value:1.07E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.68|P-value:2.99E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.02|P-value:4.93E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.77|P-value:9.64E-8 ID:SGTC_751|Compound:0833-0568|FD-Score:3.04|P-value:4.54E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-4.10|P-value:3.85E-6 ID:SGTC_771|Compound:0250-0039|FD-Score:-2.86|P-value:9.03E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:2.84|P-value:9.93E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:-3.00|P-value:5.27E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.84|P-value:1.38E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.35|P-value:1.31E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.38|P-value:1.15E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-2.91|P-value:7.50E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:-3.81|P-value:1.58E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.63|P-value:3.65E-5 ID:SGTC_1519|Compound:esterone|FD-Score:-3.15|P-value:2.93E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.14|P-value:3.11E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:7.30|P-value:8.08E-16 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.11|P-value:3.41E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.04|P-value:4.53E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.20|P-value:2.42E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.71|P-value:2.58E-5 ID:SGTC_1652|Compound:st011932|FD-Score:2.92|P-value:7.29E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.57|P-value:3.05E-7 ID:SGTC_1769|Compound:st044406|FD-Score:2.94|P-value:6.78E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.04|P-value:4.49E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-3.88|P-value:1.11E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-3.23|P-value:2.09E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.25|P-value:1.92E-4 ID:SGTC_1979|Compound:st071809|FD-Score:4.20|P-value:2.32E-6 ID:SGTC_1990|Compound:st072050|FD-Score:-3.63|P-value:3.65E-5 ID:SGTC_2000|Compound:st075254|FD-Score:4.91|P-value:4.19E-8 ID:SGTC_2173|Compound:5763948|FD-Score:-2.89|P-value:8.02E-4 ID:SGTC_2292|Compound:7671323|FD-Score:4.31|P-value:1.31E-6 ID:SGTC_2295|Compound:7971645|FD-Score:3.50|P-value:6.60E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.12|P-value:3.32E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.19|P-value:2.49E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.26|P-value:1.89E-4 ID:SGTC_2717|Compound:st081029|FD-Score:2.93|P-value:7.09E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-4.04|P-value:5.11E-6 ID:SGTC_3004|Compound:9076122|FD-Score:3.54|P-value:5.62E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-4.64|P-value:2.05E-7 ID:SGTC_3192|Compound:9110362|FD-Score:-4.30|P-value:1.29E-6 ID:SGTC_3196|Compound:9111891|FD-Score:-4.78|P-value:8.74E-8 ID:SGTC_3198|Compound:9112019|FD-Score:-5.08|P-value:1.46E-8

Top fitness defect scores for YGR084C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1524 corynanthine 7.30 62.1 µM 8.08E-16 2 1.42E-13
2 SGTC_159 3970-0959 5.16 50.0 µM 9.04E-9 36 1.24E-7
3 SGTC_2000 st075254 4.91 36.4 µM 4.19E-8 2 4.52E-7
4 SGTC_651 3253-0966 4.77 34.4 µM 9.64E-8 calcium & mitochondrial duress 18 9.12E-7
5 SGTC_1739 st037196 4.57 92.5 µM 3.05E-7 11 2.42E-6
6 SGTC_2292 7671323 4.31 168.1 µM 1.31E-6 RNA processing & uracil transport 21 8.27E-6
7 SGTC_1979 st071809 4.20 45.3 µM 2.32E-6 RPP1 & pyrimidine depletion 9 1.34E-5
8 SGTC_1071 trifluoperazine 3.84 6.3 µM 1.38E-5 28 6.08E-5
9 SGTC_364 0083-0097 3.68 67.7 µM 2.92E-5 32 1.14E-4
10 SGTC_606 k015-0008 3.68 38.6 µM 2.99E-5 20 1.17E-4
11 SGTC_349 k015-0014 3.62 24.0 µM 4.00E-5 31 1.50E-4
12 SGTC_500 h-89 3.57 112.0 µM 4.88E-5 cell wall signaling 40 1.77E-4
13 SGTC_3004 9076122 3.54 71.4 µM 5.62E-5 25 1.99E-4
14 SGTC_2295 7971645 3.50 200.0 µM 6.60E-5 37 2.29E-4
15 SGTC_565 1418-0001 3.39 44.5 µM 1.07E-4 42 3.44E-4
16 SGTC_1422 4031-0024 3.38 15.5 µM 1.15E-4 iron homeostasis 34 3.65E-4
17 SGTC_519 k048-0011 3.37 62.8 µM 1.21E-4 38 3.82E-4
18 SGTC_1409 3909-8004 3.35 61.9 µM 1.31E-4 44 4.09E-4
19 SGTC_345 1362-0200 3.28 395.0 µM 1.74E-4 38 5.20E-4
20 SGTC_2375 9072683 3.26 200.0 µM 1.89E-4 mitochondrial processes 36 5.58E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 4.23E-13 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.115 2.22E-11 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.111 1.38E-10 YDR009W GAL3 hom Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication
0.107 5.87E-10 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.102 3.20E-9 YDR001C NTH1 hom Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
0.100 7.73E-9 YDL229W SSB1 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication
0.095 3.16E-8 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.093 8.07E-8 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.090 2.10E-7 YDL225W SHS1 hom Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress
0.089 2.33E-7 YDL128W VCX1 hom Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
0.088 3.47E-7 YKL167C MRP49 hom Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
0.087 3.95E-7 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.084 1.11E-6 YDR022C ATG31 hom Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
0.084 1.24E-6 YDR471W RPL27B hom Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication
0.078 5.97E-6 YOR316C COT1 hom Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication